DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli

Byeong Taek Lee, Hwa Young Lee, Changsu Han, Chi Un Pae, Woo Suk Tae, Min-Soo Lee, Sook Haeng Joe, In Kwa Jung, Byung-Joo Ham

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

DRD2/ANKK1 TaqI A polymorphism has been suggested to be involved in a reward-related psychiatric disorders. However, the effect of Dopamine receptor D2 (DRD2) on emotional processing has not been investigated yet. We investigated the possible relationship between DRD2/ANKK1 TaqI A polymorphism and corticostriatal response to negative facial stimuli using functional magnetic resonance imaging. All participants were genotyped with regard to the DRD2/ANKK1 TaqI A polymorphism. Our results suggest an association between the DRD2/ANKK1 TaqI A polymorphism and activations in the putamen, the anterior cingulate cortex, and amygdala in response to negative facial stimuli. Furthermore, molecular heterosis at the TaqI polymorphism of DRD2/ANKK1 may play an important role in affective regulation by corticostriatal pathway.

Original languageEnglish
Pages (from-to)36-41
Number of pages6
JournalBehavioural Brain Research
Volume223
Issue number1
DOIs
Publication statusPublished - 2011 Sep 30

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Keywords

  • Dopamine receptor D2
  • FMRI
  • Polymorphism
  • Striatum

ASJC Scopus subject areas

  • Behavioral Neuroscience

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