DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli

Byeong Taek Lee, Hwa Young Lee, Changsu Han, Chi Un Pae, Woo Suk Tae, Min Soo Lee, Sook Haeng Joe, In Kwa Jung, Byung Joo Ham

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

DRD2/ANKK1 TaqI A polymorphism has been suggested to be involved in a reward-related psychiatric disorders. However, the effect of Dopamine receptor D2 (DRD2) on emotional processing has not been investigated yet. We investigated the possible relationship between DRD2/ANKK1 TaqI A polymorphism and corticostriatal response to negative facial stimuli using functional magnetic resonance imaging. All participants were genotyped with regard to the DRD2/ANKK1 TaqI A polymorphism. Our results suggest an association between the DRD2/ANKK1 TaqI A polymorphism and activations in the putamen, the anterior cingulate cortex, and amygdala in response to negative facial stimuli. Furthermore, molecular heterosis at the TaqI polymorphism of DRD2/ANKK1 may play an important role in affective regulation by corticostriatal pathway.

Original languageEnglish
Pages (from-to)36-41
Number of pages6
JournalBehavioural Brain Research
Volume223
Issue number1
DOIs
Publication statusPublished - 2011 Sep 30

Keywords

  • Dopamine receptor D2
  • FMRI
  • Polymorphism
  • Striatum

ASJC Scopus subject areas

  • Behavioral Neuroscience

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