DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli

Byeong Taek Lee, Hwa Young Lee, Changsu Han, Chi Un Pae, Woo Suk Tae, Min-Soo Lee, Sook Haeng Joe, In Kwa Jung, Byung-Joo Ham

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

DRD2/ANKK1 TaqI A polymorphism has been suggested to be involved in a reward-related psychiatric disorders. However, the effect of Dopamine receptor D2 (DRD2) on emotional processing has not been investigated yet. We investigated the possible relationship between DRD2/ANKK1 TaqI A polymorphism and corticostriatal response to negative facial stimuli using functional magnetic resonance imaging. All participants were genotyped with regard to the DRD2/ANKK1 TaqI A polymorphism. Our results suggest an association between the DRD2/ANKK1 TaqI A polymorphism and activations in the putamen, the anterior cingulate cortex, and amygdala in response to negative facial stimuli. Furthermore, molecular heterosis at the TaqI polymorphism of DRD2/ANKK1 may play an important role in affective regulation by corticostriatal pathway.

Original languageEnglish
Pages (from-to)36-41
Number of pages6
JournalBehavioural Brain Research
Volume223
Issue number1
DOIs
Publication statusPublished - 2011 Sep 30

Fingerprint

Dopamine D2 Receptors
Hybrid Vigor
Putamen
Gyrus Cinguli
Dopamine Receptors
Amygdala
Reward
Psychiatry
Magnetic Resonance Imaging

Keywords

  • Dopamine receptor D2
  • FMRI
  • Polymorphism
  • Striatum

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli. / Lee, Byeong Taek; Lee, Hwa Young; Han, Changsu; Pae, Chi Un; Tae, Woo Suk; Lee, Min-Soo; Joe, Sook Haeng; Jung, In Kwa; Ham, Byung-Joo.

In: Behavioural Brain Research, Vol. 223, No. 1, 30.09.2011, p. 36-41.

Research output: Contribution to journalArticle

Lee, Byeong Taek ; Lee, Hwa Young ; Han, Changsu ; Pae, Chi Un ; Tae, Woo Suk ; Lee, Min-Soo ; Joe, Sook Haeng ; Jung, In Kwa ; Ham, Byung-Joo. / DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli. In: Behavioural Brain Research. 2011 ; Vol. 223, No. 1. pp. 36-41.
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