DRD3 Gene rs6280 Polymorphism May Be Associated with Alcohol Dependence Overall and with Lesch Type I Alcohol Dependence in Koreans

Seung Gul Kang, Bun Hee Lee, Jun Seok Lee, Young Gyu Chai, Kwang Pil Ko, Heon-Jeong Lee, Dal Mu Ri Han, Hong Ji, Gyeong Ho Jang, Hye Eun Shin

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Several polymorphisms of the dopamine D3 receptor (DRD3) gene are reported to be involved in the susceptibility to alcoholism. Although the DRD3 rs6280 (Ser9Gly) polymorphism plays an important role in various psychiatric disorders, findings regarding the association between this single-nucleotide polymorphism (SNP) and alcohol dependence (AD) have been inconsistent. Therefore, the present study investigated the association between the DRD3 gene rs6280 polymorphism with AD and Lesch type I AD in Korean subjects. Methods: The DRD3 rs6280 SNP was genotyped in a case-control sample comprising 245 AD patients and 130 healthy controls (HCs). Alcohol Use Disorders Identification Test (AUDIT) scores were also compared relative to genotype in all of the participants. Results: This SNP was significantly associated with both AD overall (χ2 = 10.09 and p = 0.001, and χ2 = 10.60 and p = 0.005, for the recessive and additive models, respectively) and with Lesch type I AD (χ2 = 11.70 and p = 0.001, and χ2 = 11.70 and p = 0.003, for the recessive and additive models, respectively). The allele frequency differed significantly (χ2 = 8.45, p = 0.004) between Lesch type I AD and HC subjects. The AUDIT total (F = 6.56, p = 0.011), hazardous alcohol use (F = 7.12, p = 0.008), dependence symptoms (F = 5.10, p = 0.025), and harmful alcohol use (F = 4.83, p = 0.029) scores were significantly higher in those who did not possess the S allele (genotype GG) than in those who did (genotypes SS ± SG). Conclusions: The findings of this study suggest that the DRD3 rs6280 polymorphism is associated with the development of both AD overall and Lesch type I AD in Koreans.

Original languageEnglish
Pages (from-to)140-146
Number of pages7
JournalNeuropsychobiology
Volume69
Issue number3
DOIs
Publication statusAccepted/In press - 2014 Apr 26

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Alcoholism
Genes
Alcohols
Single Nucleotide Polymorphism
Genotype
Dopamine D3 Receptors
Gene Frequency
Psychiatry
Healthy Volunteers
Alleles

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Biological Psychiatry
  • Psychiatry and Mental health

Cite this

DRD3 Gene rs6280 Polymorphism May Be Associated with Alcohol Dependence Overall and with Lesch Type I Alcohol Dependence in Koreans. / Kang, Seung Gul; Lee, Bun Hee; Lee, Jun Seok; Chai, Young Gyu; Ko, Kwang Pil; Lee, Heon-Jeong; Han, Dal Mu Ri; Ji, Hong; Jang, Gyeong Ho; Shin, Hye Eun.

In: Neuropsychobiology, Vol. 69, No. 3, 26.04.2014, p. 140-146.

Research output: Contribution to journalArticle

Kang, Seung Gul ; Lee, Bun Hee ; Lee, Jun Seok ; Chai, Young Gyu ; Ko, Kwang Pil ; Lee, Heon-Jeong ; Han, Dal Mu Ri ; Ji, Hong ; Jang, Gyeong Ho ; Shin, Hye Eun. / DRD3 Gene rs6280 Polymorphism May Be Associated with Alcohol Dependence Overall and with Lesch Type I Alcohol Dependence in Koreans. In: Neuropsychobiology. 2014 ; Vol. 69, No. 3. pp. 140-146.
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abstract = "Background: Several polymorphisms of the dopamine D3 receptor (DRD3) gene are reported to be involved in the susceptibility to alcoholism. Although the DRD3 rs6280 (Ser9Gly) polymorphism plays an important role in various psychiatric disorders, findings regarding the association between this single-nucleotide polymorphism (SNP) and alcohol dependence (AD) have been inconsistent. Therefore, the present study investigated the association between the DRD3 gene rs6280 polymorphism with AD and Lesch type I AD in Korean subjects. Methods: The DRD3 rs6280 SNP was genotyped in a case-control sample comprising 245 AD patients and 130 healthy controls (HCs). Alcohol Use Disorders Identification Test (AUDIT) scores were also compared relative to genotype in all of the participants. Results: This SNP was significantly associated with both AD overall (χ2 = 10.09 and p = 0.001, and χ2 = 10.60 and p = 0.005, for the recessive and additive models, respectively) and with Lesch type I AD (χ2 = 11.70 and p = 0.001, and χ2 = 11.70 and p = 0.003, for the recessive and additive models, respectively). The allele frequency differed significantly (χ2 = 8.45, p = 0.004) between Lesch type I AD and HC subjects. The AUDIT total (F = 6.56, p = 0.011), hazardous alcohol use (F = 7.12, p = 0.008), dependence symptoms (F = 5.10, p = 0.025), and harmful alcohol use (F = 4.83, p = 0.029) scores were significantly higher in those who did not possess the S allele (genotype GG) than in those who did (genotypes SS ± SG). Conclusions: The findings of this study suggest that the DRD3 rs6280 polymorphism is associated with the development of both AD overall and Lesch type I AD in Koreans.",
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T1 - DRD3 Gene rs6280 Polymorphism May Be Associated with Alcohol Dependence Overall and with Lesch Type I Alcohol Dependence in Koreans

AU - Kang, Seung Gul

AU - Lee, Bun Hee

AU - Lee, Jun Seok

AU - Chai, Young Gyu

AU - Ko, Kwang Pil

AU - Lee, Heon-Jeong

AU - Han, Dal Mu Ri

AU - Ji, Hong

AU - Jang, Gyeong Ho

AU - Shin, Hye Eun

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N2 - Background: Several polymorphisms of the dopamine D3 receptor (DRD3) gene are reported to be involved in the susceptibility to alcoholism. Although the DRD3 rs6280 (Ser9Gly) polymorphism plays an important role in various psychiatric disorders, findings regarding the association between this single-nucleotide polymorphism (SNP) and alcohol dependence (AD) have been inconsistent. Therefore, the present study investigated the association between the DRD3 gene rs6280 polymorphism with AD and Lesch type I AD in Korean subjects. Methods: The DRD3 rs6280 SNP was genotyped in a case-control sample comprising 245 AD patients and 130 healthy controls (HCs). Alcohol Use Disorders Identification Test (AUDIT) scores were also compared relative to genotype in all of the participants. Results: This SNP was significantly associated with both AD overall (χ2 = 10.09 and p = 0.001, and χ2 = 10.60 and p = 0.005, for the recessive and additive models, respectively) and with Lesch type I AD (χ2 = 11.70 and p = 0.001, and χ2 = 11.70 and p = 0.003, for the recessive and additive models, respectively). The allele frequency differed significantly (χ2 = 8.45, p = 0.004) between Lesch type I AD and HC subjects. The AUDIT total (F = 6.56, p = 0.011), hazardous alcohol use (F = 7.12, p = 0.008), dependence symptoms (F = 5.10, p = 0.025), and harmful alcohol use (F = 4.83, p = 0.029) scores were significantly higher in those who did not possess the S allele (genotype GG) than in those who did (genotypes SS ± SG). Conclusions: The findings of this study suggest that the DRD3 rs6280 polymorphism is associated with the development of both AD overall and Lesch type I AD in Koreans.

AB - Background: Several polymorphisms of the dopamine D3 receptor (DRD3) gene are reported to be involved in the susceptibility to alcoholism. Although the DRD3 rs6280 (Ser9Gly) polymorphism plays an important role in various psychiatric disorders, findings regarding the association between this single-nucleotide polymorphism (SNP) and alcohol dependence (AD) have been inconsistent. Therefore, the present study investigated the association between the DRD3 gene rs6280 polymorphism with AD and Lesch type I AD in Korean subjects. Methods: The DRD3 rs6280 SNP was genotyped in a case-control sample comprising 245 AD patients and 130 healthy controls (HCs). Alcohol Use Disorders Identification Test (AUDIT) scores were also compared relative to genotype in all of the participants. Results: This SNP was significantly associated with both AD overall (χ2 = 10.09 and p = 0.001, and χ2 = 10.60 and p = 0.005, for the recessive and additive models, respectively) and with Lesch type I AD (χ2 = 11.70 and p = 0.001, and χ2 = 11.70 and p = 0.003, for the recessive and additive models, respectively). The allele frequency differed significantly (χ2 = 8.45, p = 0.004) between Lesch type I AD and HC subjects. The AUDIT total (F = 6.56, p = 0.011), hazardous alcohol use (F = 7.12, p = 0.008), dependence symptoms (F = 5.10, p = 0.025), and harmful alcohol use (F = 4.83, p = 0.029) scores were significantly higher in those who did not possess the S allele (genotype GG) than in those who did (genotypes SS ± SG). Conclusions: The findings of this study suggest that the DRD3 rs6280 polymorphism is associated with the development of both AD overall and Lesch type I AD in Koreans.

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