Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells

Kyoung Ran Kim, Da Rae Kim, Taemin Lee, Ji Young Yhee, Byeong Su Kim, Ick Chan Kwon, Dae Ro Ahn

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

A DNA tetrahedron is employed for efficient delivery of doxorubicin into drug-resistant breast cancer cells. The drug delivered with the DNA nanoconstruct is considerably cytotoxic, whereas free doxorubicin is virtually non-cytotoxic for the drug-resistant cells. Thus, the DNA tetrahedron, made of the inherently natural and biocompatible material, can be a good candidate for the drug carrier to overcome MDR in cancer cells.

Original languageEnglish
Pages (from-to)2010-2012
Number of pages3
JournalChemical Communications
Volume49
Issue number20
DOIs
Publication statusPublished - 2013 Mar 11
Externally publishedYes

Fingerprint

Drug delivery
Drug Resistance
DNA
Cells
Breast Neoplasms
Doxorubicin
Pharmaceutical Preparations
Drug Carriers
Biocompatible Materials
Biomaterials
Neoplasms

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Kim, K. R., Kim, D. R., Lee, T., Yhee, J. Y., Kim, B. S., Kwon, I. C., & Ahn, D. R. (2013). Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells. Chemical Communications, 49(20), 2010-2012. https://doi.org/10.1039/c3cc38693g

Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells. / Kim, Kyoung Ran; Kim, Da Rae; Lee, Taemin; Yhee, Ji Young; Kim, Byeong Su; Kwon, Ick Chan; Ahn, Dae Ro.

In: Chemical Communications, Vol. 49, No. 20, 11.03.2013, p. 2010-2012.

Research output: Contribution to journalArticle

Kim, KR, Kim, DR, Lee, T, Yhee, JY, Kim, BS, Kwon, IC & Ahn, DR 2013, 'Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells', Chemical Communications, vol. 49, no. 20, pp. 2010-2012. https://doi.org/10.1039/c3cc38693g
Kim, Kyoung Ran ; Kim, Da Rae ; Lee, Taemin ; Yhee, Ji Young ; Kim, Byeong Su ; Kwon, Ick Chan ; Ahn, Dae Ro. / Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells. In: Chemical Communications. 2013 ; Vol. 49, No. 20. pp. 2010-2012.
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