Drug release behavior of poly(ε-caprolactone)-b-poly(acrylic acid) shell crosslinked micelles below the critical micelle concentration

Woo Hong Sung, Hyeong Kim Keon, June Huh, Cheol Hee Ahn, Ho Jo Won

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

To explore the potential of shell crosslinked micelle (SCM) as a drug carrier, the drug release behavior of poly(ε-caprolactone)-b-poly(acrylic acid) (PCL-b-PAA) SCMs was investigated. PCL-b-PAA was synthesized by ring opening polymerization of ε-caprolactone and atom transfer radical polymerization of tert-butyl acrylate, followed by selective hydrolysis of tert-butyl ester groups to acrylic acid groups. The resulting amphiphilic polymer was used to prepare SCMs by crosslinking of PAA corona via amidation chemistry. The drug release behavior of the SCMs was studied, using pyrene as a model drug, and was compared with that of non-crosslinked micelles, especially below the critical micelle concentration (CMC). When the shell layers were crosslinked, the drug release behavior of the SCMs was successfully modulated at a controlled rate compared with that of the non-crosslinked micelles, which showed a burst release of drug within a short time.

Original languageEnglish
Pages (from-to)397-402
Number of pages6
JournalMacromolecular Research
Volume13
Issue number5
Publication statusPublished - 2005 Oct 1
Externally publishedYes

Fingerprint

carbopol 940
Critical micelle concentration
Micelles
Acrylics
Acids
Pharmaceutical Preparations
Atom transfer radical polymerization
Ring opening polymerization
Pyrene
Crosslinking
Hydrolysis
Esters
Drug Carriers
Polymers
polycaprolactone

Keywords

  • PAA
  • PCL
  • Release
  • Shell crosslinked micelles

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Drug release behavior of poly(ε-caprolactone)-b-poly(acrylic acid) shell crosslinked micelles below the critical micelle concentration. / Sung, Woo Hong; Keon, Hyeong Kim; Huh, June; Ahn, Cheol Hee; Won, Ho Jo.

In: Macromolecular Research, Vol. 13, No. 5, 01.10.2005, p. 397-402.

Research output: Contribution to journalArticle

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