Drug release from a chemically-anchored PEG/phospholipid monolayer onto polymer-coated metallic stents

Ohm Divyam Krishna, Ok Cheol Jeon, Kwang Meyung Kim, Youngro Byun, Hyun Tae Moon

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We have prepared a covalently-grafted phsopholipid/PEG mixed monolayer onto drug-loaded polymercoated stainless-steel stents by in situ polymerization. To introduce a biocompatile surface on the stent surface, AcPC (1-palmitoyl-2-[12- (acryloyloxy)dodecanoyl]-sn-glycero-3-phosphocholine) and AcPEG (12-(acryloyloxy)dodecanoyl-poly(ethylene glycol)) were synthesized by modifying phospholipid and PEG with 12-(acryloyloxy)-1-dodecanoic acid and 12-(acryloyloxy)-1-dodecanol, respectively. Also, an acrylated co-polymer was synthesized by the acrylation of poly(octadecyl acrylate-co-hydroxybutyl acrylate, poly(OA-co-HA)) with acryloyl chloride, and poly(OA-co-HA) loaded with a hydrophobic drug, echinomycin, was coated on the stent surface using a spray coating system. In situ polymerization was carried out at the interface between a pre-assembled AcPC/AcPEG mixture and the enchinomycin-loaded acrylated co-polymer-coated stainless steel (Pol-SS). The physicochemical properties of a covalently-grafted phsopholipid/PEG mixed monolayer onto the drug-loaded polymer-coated stainless-steel stents were evaluated using water contact angle, field-emission scanning electron microscopy (FE-SEM) and X-ray photoelectron spectroscopy (XPS). The data confirmed a successful phsopholipid/PEG monolayer grafting on the stents surface. The drug-release profile showed a sustained and controllable release pattern by the top-coated stents, achieved by adjusting the amount of loaded drug.

Original languageEnglish
Pages (from-to)789-802
Number of pages14
JournalJournal of Biomaterials Science, Polymer Edition
Volume21
Issue number6-7
DOIs
Publication statusPublished - 2010 Apr 1
Externally publishedYes

Fingerprint

Stents
Phospholipids
Polyethylene glycols
Monolayers
Polymers
Stainless Steel
Pharmaceutical Preparations
lauric acid
Stainless steel
Ethylene Glycol
Polymerization
Echinomycin
Dodecanol
Photoelectron Spectroscopy
Phosphorylcholine
Field emission
Electron Scanning Microscopy
Contact angle
Drug Liberation
X ray photoelectron spectroscopy

Keywords

  • Biocompatibility
  • Drug-eluting stent
  • In situ polymerization
  • PEG/phospholipid monolayer

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Drug release from a chemically-anchored PEG/phospholipid monolayer onto polymer-coated metallic stents. / Krishna, Ohm Divyam; Jeon, Ok Cheol; Kim, Kwang Meyung; Byun, Youngro; Moon, Hyun Tae.

In: Journal of Biomaterials Science, Polymer Edition, Vol. 21, No. 6-7, 01.04.2010, p. 789-802.

Research output: Contribution to journalArticle

Krishna, Ohm Divyam ; Jeon, Ok Cheol ; Kim, Kwang Meyung ; Byun, Youngro ; Moon, Hyun Tae. / Drug release from a chemically-anchored PEG/phospholipid monolayer onto polymer-coated metallic stents. In: Journal of Biomaterials Science, Polymer Edition. 2010 ; Vol. 21, No. 6-7. pp. 789-802.
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