Drug release from electric current sensitive polymers

Ick Chan Kwon, You Han Bae, Teruo Okano, Sung Wan Kim

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

The crosslinked polymer, poly(2-acrylamido-2-methylpropane sulfonic acid-co-n-butylmethacrylate) [poly (AMPS/BMA)], was synthesized to study the effect of electric current on solute release. Edrophonium chloride, a positively charged solute was released in an on-off pattern from a poly(AMPS/BMA) monolithic device with electric stimulus. The on-off release mechanism of the positively charged solute was explained as an ion exchange between positive solute and hydroxonium ion, followed by fast release of the exchanged solute from the gel. The fast release was attributed to the electrostatic force, squeezing effect and the electro-osmosis of the gel. However, the release of neutral solute hydrocortisone was controlled by diffusion mechanism affected by swelling and deswelling of the gel.

Original languageEnglish
JournalJournal of Controlled Release
Volume17
Issue number2
Publication statusPublished - 1991 Oct 1
Externally publishedYes

Fingerprint

Polymers
Gels
Edrophonium
Osmosis
Sulfonic Acids
Ion Exchange
Static Electricity
Hydrocortisone
Ions
Equipment and Supplies
Drug Liberation

Keywords

  • Drug delivery systems
  • Ion exchange
  • On-off switching release
  • Polyelectrolytes
  • Stimuli sensitive polymer

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Kwon, I. C., Bae, Y. H., Okano, T., & Kim, S. W. (1991). Drug release from electric current sensitive polymers. Journal of Controlled Release, 17(2).

Drug release from electric current sensitive polymers. / Kwon, Ick Chan; Bae, You Han; Okano, Teruo; Kim, Sung Wan.

In: Journal of Controlled Release, Vol. 17, No. 2, 01.10.1991.

Research output: Contribution to journalArticle

Kwon, IC, Bae, YH, Okano, T & Kim, SW 1991, 'Drug release from electric current sensitive polymers', Journal of Controlled Release, vol. 17, no. 2.
Kwon IC, Bae YH, Okano T, Kim SW. Drug release from electric current sensitive polymers. Journal of Controlled Release. 1991 Oct 1;17(2).
Kwon, Ick Chan ; Bae, You Han ; Okano, Teruo ; Kim, Sung Wan. / Drug release from electric current sensitive polymers. In: Journal of Controlled Release. 1991 ; Vol. 17, No. 2.
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