Drug release from electric current sensitive polymers

Ick Chan Kwon, You Han Bae, Teruo Okano, Sung Wan Kim

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

The crosslinked polymer, poly(2-acrylamido-2-methylpropane sulfonic acid-co-n-butylmethacrylate) [poly (AMPS/BMA)], was synthesized to study the effect of electric current on solute release. Edrophonium chloride, a positively charged solute was released in an on-off pattern from a poly(AMPS/BMA) monolithic device with electric stimulus. The on-off release mechanism of the positively charged solute was explained as an ion exchange between positive solute and hydroxonium ion, followed by fast release of the exchanged solute from the gel. The fast release was attributed to the electrostatic force, squeezing effect and the electro-osmosis of the gel. However, the release of neutral solute hydrocortisone was controlled by diffusion mechanism affected by swelling and deswelling of the gel.

Original languageEnglish
Pages (from-to)149-153,156
JournalJournal of Controlled Release
Volume17
Issue number2
DOIs
Publication statusPublished - 1991 Oct

Keywords

  • Drug delivery systems
  • Ion exchange
  • On-off switching release
  • Polyelectrolytes
  • Stimuli sensitive polymer

ASJC Scopus subject areas

  • Pharmaceutical Science

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