Drug-sensitive tuberculosis, multidrug-resistant tuberculosis, and nontuberculous mycobacterial pulmonary disease in nonAIDS adults: Comparisons of thin-section CT findings

Myung Jin Chung, Kyung Soo Lee, Won Jung Koh, Tae Sung Kim, Eun Young Kang, Sung Mok Kim, O. Jung Kwon, Seonwoo Kim

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    41 Citations (Scopus)

    Abstract

    The aim of this work was to compare thin-section CT (TSCT) findings of drug-sensitive (DS) tuberculosis (TB), multidrug-resistant (MDR) TB, and nontuberculous mycobacterial (NTM) pulmonary disease in nonAIDS adults. During 2003, 216 (113 DS TB, 35 MDR TB, and 68 NTM) patients with smear-positive sputum for acid-fast bacilli (AFB), and who were subsequently confirmed to have mycobacterial pulmonary disease, underwent thoracic TSCT. The frequency of lung lesion patterns on TSCT and patients' demographic data were compared. The commonest TSCT findings were tree-in-bud opacities and nodules. On a per-person basis, significant differences were found in the frequency of multiple cavities and bronchiectasis (P<0.001, chi-square test and multiple logistic regression analysis). Multiple cavities were more frequent in MDR TB than in the other two groups and extensive bronchiectasis in NTM disease (multiple logistic regression analysis). Patients with MDR TB were younger than those with DS TB or NTM disease (P<0.001, multiple logistic regression analysis). Previous tuberculosis treatment history was significantly more frequent in patients with MDR TB or NTM disease (P<0.001, chi-square test and multiple logistic regression analysis). In patients with positive sputum AFB, multiple cavities, young age, and previous tuberculosis treatment history imply MDR TB, whereas extensive bronchiectasis, old age, and previous tuberculosis treatment history NTM disease.

    Original languageEnglish
    Pages (from-to)1934-1941
    Number of pages8
    JournalEuropean Radiology
    Volume16
    Issue number9
    DOIs
    Publication statusPublished - 2006 Sep

    Keywords

    • Lung, CT
    • Lung, diseases
    • Lung, infection
    • Mycobacteria

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

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