Drug-sensitive tuberculosis, multidrug-resistant tuberculosis, and nontuberculous mycobacterial pulmonary disease in nonAIDS adults: Comparisons of thin-section CT findings

Myung Jin Chung, Kyung Soo Lee, Won Jung Koh, Tae Sung Kim, Eun-Young Kang, Sung Mok Kim, O. Jung Kwon, Seonwoo Kim

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The aim of this work was to compare thin-section CT (TSCT) findings of drug-sensitive (DS) tuberculosis (TB), multidrug-resistant (MDR) TB, and nontuberculous mycobacterial (NTM) pulmonary disease in nonAIDS adults. During 2003, 216 (113 DS TB, 35 MDR TB, and 68 NTM) patients with smear-positive sputum for acid-fast bacilli (AFB), and who were subsequently confirmed to have mycobacterial pulmonary disease, underwent thoracic TSCT. The frequency of lung lesion patterns on TSCT and patients' demographic data were compared. The commonest TSCT findings were tree-in-bud opacities and nodules. On a per-person basis, significant differences were found in the frequency of multiple cavities and bronchiectasis (P<0.001, chi-square test and multiple logistic regression analysis). Multiple cavities were more frequent in MDR TB than in the other two groups and extensive bronchiectasis in NTM disease (multiple logistic regression analysis). Patients with MDR TB were younger than those with DS TB or NTM disease (P<0.001, multiple logistic regression analysis). Previous tuberculosis treatment history was significantly more frequent in patients with MDR TB or NTM disease (P<0.001, chi-square test and multiple logistic regression analysis). In patients with positive sputum AFB, multiple cavities, young age, and previous tuberculosis treatment history imply MDR TB, whereas extensive bronchiectasis, old age, and previous tuberculosis treatment history NTM disease.

Original languageEnglish
Pages (from-to)1934-1941
Number of pages8
JournalEuropean Radiology
Volume16
Issue number9
DOIs
Publication statusPublished - 2006 Sep 1

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Multidrug-Resistant Tuberculosis
Lung Diseases
Tuberculosis
Bronchiectasis
Logistic Models
Regression Analysis
Pharmaceutical Preparations
History
Chi-Square Distribution
Sputum
Bacillus
Acids
Thorax
Therapeutics
Demography
Lung

Keywords

  • Lung, CT
  • Lung, diseases
  • Lung, infection
  • Mycobacteria

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Drug-sensitive tuberculosis, multidrug-resistant tuberculosis, and nontuberculous mycobacterial pulmonary disease in nonAIDS adults : Comparisons of thin-section CT findings. / Chung, Myung Jin; Lee, Kyung Soo; Koh, Won Jung; Kim, Tae Sung; Kang, Eun-Young; Kim, Sung Mok; Kwon, O. Jung; Kim, Seonwoo.

In: European Radiology, Vol. 16, No. 9, 01.09.2006, p. 1934-1941.

Research output: Contribution to journalArticle

Chung, Myung Jin ; Lee, Kyung Soo ; Koh, Won Jung ; Kim, Tae Sung ; Kang, Eun-Young ; Kim, Sung Mok ; Kwon, O. Jung ; Kim, Seonwoo. / Drug-sensitive tuberculosis, multidrug-resistant tuberculosis, and nontuberculous mycobacterial pulmonary disease in nonAIDS adults : Comparisons of thin-section CT findings. In: European Radiology. 2006 ; Vol. 16, No. 9. pp. 1934-1941.
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