Drug susceptibility patterns of Mycobacterium abscessus and Mycobacterium massiliense isolated from respiratory specimens

Eun Hye Cho, Hee Jae Huh, Dong Joon Song, Seung Heon Lee, Chang Ki Kim, So Youn Shin, Chang Seok Ki, Byung Woo Jhun, Seong Mi Moon, O. Jung Kwon, Won Jung Koh, Nam Yong Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In this study, we aimed to retrospectively investigate and compare the drug susceptibility patterns of two major Mycobacterium abscessus complex (MABC) species; M. abscessus and M. massiliense. A total of 546 MABC respiratory isolates (277 M. abscessus and 269 M. massiliense) from 2011 to 2016 were analyzed in this study. We estimated minimum inhibitory concentrations (MICs) using the broth microdilution method, and we calculated MIC 50 and MIC 90 values from the MIC distribution. Both M. abscessus and M. massiliense were highly susceptible to amikacin and linezolid. For M. abscessus, the proportions of inducible and acquired resistance to clarithromycin were 68.6% and 12.3%, respectively. Only 15.2% of M. abscessus remained susceptible at day 14. On the other hand, none of the M. massiliense showed inducible resistance and 6.3% showed acquired resistance to clarithromycin. A total of 92.6% of the M. massiliense remained susceptible at day 14. The resistance rate of M. abscessus to moxifloxacin (90.3%) was significantly higher than that of M. massiliense (83.3%; p = 0.016). These susceptibility differences may explain the divergent treatment outcomes between patients with pulmonary disease caused by these two species.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalDiagnostic Microbiology and Infectious Disease
Volume93
Issue number2
DOIs
Publication statusPublished - 2019 Feb 1
Externally publishedYes

Keywords

  • Drug susceptibility test
  • Mycobacterium abscessus
  • Mycobacterium massiliense
  • Nontuberculous mycobacteria

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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    Cho, E. H., Huh, H. J., Song, D. J., Lee, S. H., Kim, C. K., Shin, S. Y., Ki, C. S., Jhun, B. W., Moon, S. M., Kwon, O. J., Koh, W. J., & Lee, N. Y. (2019). Drug susceptibility patterns of Mycobacterium abscessus and Mycobacterium massiliense isolated from respiratory specimens. Diagnostic Microbiology and Infectious Disease, 93(2), 107-111. https://doi.org/10.1016/j.diagmicrobio.2018.08.008