DSigDB

Drug signatures database for gene set analysis

Minjae Yoo, Jimin Shin, Jihye Kim, Karen A. Ryall, Kyubum Lee, Sunwon Lee, Minji Jeon, Jaewoo Kang, Aik-Choon Tan

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

We report the creation of Drug Signatures Database (DSigDB), a new gene set resource that relates drugs/compounds and their target genes, for gene set enrichment analysis (GSEA). DSigDB currently holds 22 527 gene sets, consists of 17 389 unique compounds covering 19 531 genes. We also developed an online DSigDB resource that allows users to search, view and download drugs/compounds and gene sets. DSigDB gene sets provide seamless integration to GSEA software for linking gene expressions with drugs/compounds for drug repurposing and translational research.

Original languageEnglish
Pages (from-to)3069-3071
Number of pages3
JournalBioinformatics
Volume31
Issue number18
DOIs
Publication statusPublished - 2014 Jul 31

Fingerprint

Pharmaceutical Databases
Drugs
Signature
Genes
Gene
Pharmaceutical Preparations
Drug Repositioning
Resources
Translational Medical Research
Gene expression
Linking
Gene Expression
Covering
Software
Target

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Computational Theory and Mathematics
  • Computer Science Applications
  • Computational Mathematics
  • Statistics and Probability

Cite this

Yoo, M., Shin, J., Kim, J., Ryall, K. A., Lee, K., Lee, S., ... Tan, A-C. (2014). DSigDB: Drug signatures database for gene set analysis. Bioinformatics, 31(18), 3069-3071. https://doi.org/10.1093/bioinformatics/btv313

DSigDB : Drug signatures database for gene set analysis. / Yoo, Minjae; Shin, Jimin; Kim, Jihye; Ryall, Karen A.; Lee, Kyubum; Lee, Sunwon; Jeon, Minji; Kang, Jaewoo; Tan, Aik-Choon.

In: Bioinformatics, Vol. 31, No. 18, 31.07.2014, p. 3069-3071.

Research output: Contribution to journalArticle

Yoo, M, Shin, J, Kim, J, Ryall, KA, Lee, K, Lee, S, Jeon, M, Kang, J & Tan, A-C 2014, 'DSigDB: Drug signatures database for gene set analysis', Bioinformatics, vol. 31, no. 18, pp. 3069-3071. https://doi.org/10.1093/bioinformatics/btv313
Yoo M, Shin J, Kim J, Ryall KA, Lee K, Lee S et al. DSigDB: Drug signatures database for gene set analysis. Bioinformatics. 2014 Jul 31;31(18):3069-3071. https://doi.org/10.1093/bioinformatics/btv313
Yoo, Minjae ; Shin, Jimin ; Kim, Jihye ; Ryall, Karen A. ; Lee, Kyubum ; Lee, Sunwon ; Jeon, Minji ; Kang, Jaewoo ; Tan, Aik-Choon. / DSigDB : Drug signatures database for gene set analysis. In: Bioinformatics. 2014 ; Vol. 31, No. 18. pp. 3069-3071.
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