DSigDB: Drug signatures database for gene set analysis

Minjae Yoo, Jimin Shin, Jihye Kim, Karen A. Ryall, Kyubum Lee, Sunwon Lee, Minji Jeon, Jaewoo Kang, Aik-Choon Tan

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

We report the creation of Drug Signatures Database (DSigDB), a new gene set resource that relates drugs/compounds and their target genes, for gene set enrichment analysis (GSEA). DSigDB currently holds 22 527 gene sets, consists of 17 389 unique compounds covering 19 531 genes. We also developed an online DSigDB resource that allows users to search, view and download drugs/compounds and gene sets. DSigDB gene sets provide seamless integration to GSEA software for linking gene expressions with drugs/compounds for drug repurposing and translational research.

Original languageEnglish
Pages (from-to)3069-3071
Number of pages3
JournalBioinformatics
Volume31
Issue number18
DOIs
Publication statusPublished - 2014 Jul 31

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Computational Theory and Mathematics
  • Computer Science Applications
  • Computational Mathematics
  • Statistics and Probability

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  • Cite this

    Yoo, M., Shin, J., Kim, J., Ryall, K. A., Lee, K., Lee, S., Jeon, M., Kang, J., & Tan, A-C. (2014). DSigDB: Drug signatures database for gene set analysis. Bioinformatics, 31(18), 3069-3071. https://doi.org/10.1093/bioinformatics/btv313