Dual-color imaging of sodium/calcium ion activities with twophoton fluorescent probes

Hyung Joong Kim, Ji Hee Han, Mi Kyung Kim, Chang Su Lim, Hwan Myung Kim, Bong Rae Cho

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

A two-photon probe (BCaM) shows 14fold enhancement in two-photon emission fluorescence in response to Ca2+ and shows high sensitivity and selectivity for near-membrane Ca2+ ions (see picture). Combined with the known Na+ twophoton probe ANa1, BCaM allows simultaneous dual-color imaging of Ca2+/Na+ activities within live cells and in tissues at more than 100 μm depth for long time periods without photobleaching. (Figure Presented)

Original languageEnglish
Pages (from-to)6786-6789
Number of pages4
JournalAngewandte Chemie - International Edition
Volume49
Issue number38
DOIs
Publication statusPublished - 2010 Sep 10

Keywords

  • Calcium
  • Fluorescence spectroscopy
  • Imaging agents
  • Live tissue
  • Two-photon microscopy

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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