Dual-energy CT iodine quantification for characterizing focal thyroid lesions

Do Hyung Lee, Young Hen Lee, Hyung Suk Seo, Ki Yeol Lee, Sang il Suh, Inseon Ryoo, Sung Hye You, Byungjun Kim, Kyung Sook Yang

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Background: To determine the usefulness of dual-energy CT (DECT) iodine quantification to classify the focal thyroid lesions. Methods: We retrospectively enrolled a total of 76 cytopathologically confirmed focal thyroid lesions (mean size: 1.9 cm). After drawing a region of interest on the DECT-derived iodine maps, the obtained iodine concentration values of thyroid nodules (IC_N) and normalized IC_N were compared between 3 groups: papillary thyroid carcinoma (PTC), benign nodule, and cyst. Results: From all lesions, 46, 17, and 13 were assigned to the PTC, benign nodule, and cyst groups. IC_N was the highest in the benign nodule, lower in the PTC, and the lowest in the cyst (median [interquartile range]: 4.3 [3.13-5.48], 3.15 [2.29-4.01], 0.60 [0.33-0.88], all P <.001). Similarly, the normalized IC_N values were all statistically different from each other (P <.05).The multi-class area under the curves using the optimal cutoff values were 0.931 for IC_N and 0.918, 0.920 for normalized IC, respectively. Conclusion: DECT iodine quantification could be helpful to classify the focal thyroid lesions.

Original languageEnglish
Pages (from-to)1024-1031
Number of pages8
JournalHead and Neck
Issue number4
Publication statusPublished - 2019 Apr


  • CT
  • diagnosis
  • differential
  • dual-energy
  • iodine/analysis
  • thyroid nodule

ASJC Scopus subject areas

  • Otorhinolaryngology

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