Dual Versus Mono Antiplatelet Therapy in Large Atherosclerotic Stroke

Dohoung Kim, Jong Moo Park, Kyusik Kang, Yong Jin Cho, Keun Sik Hong, Kyung Bok Lee, Tai Hwan Park, Soo Joo Lee, Jae Guk Kim, Moon Ku Han, Beom Joon Kim, Jun Lee, Jae Kwan Cha, Dae Hyun Kim, Hyun Wook Nah, Dong Eog Kim, Wi Sun Ryu, Joon Tae Kim, Kang Ho Choi, Jay Chol ChoiByung Chul Lee, Kyung Ho Yu, Mi Sun Oh, Wook Joo Kim, Jee Hyun Kwon, Dong Ick Shin, Sung Il Sohn, Jeong Ho Hong, Ji Sung Lee, Juneyoung Lee, Philip B. Gorelick, Hee Joon Bae

Research output: Contribution to journalArticle

Abstract

Background and Purpose- Two large-scale randomized controlled trials of recurrent stroke prevention suggest that dual antiplatelet therapy with clopidogrel plus aspirin is beneficial for prevention of subsequent ischemic events. There is a paucity of data, however, on the efficacy or effectiveness of such an approach in the treatment of stroke patients with symptomatic large artery atherosclerotic occlusive disease. Methods- We used a multicenter stroke registry database (Clinical Research Collaboration for Stroke in Korea) to analyze acute ischemic stroke patients due to large artery atherosclerotic occlusive disease who were treated with aspirin alone or combination of clopidogrel and aspirin from May 2008 to May 2015. The results were analyzed by intention-to-treat, per-protocol, and as-treated methodologies. The primary end point was the 1-year composite outcome of stroke recurrence, myocardial infarction, and all-cause death. To balance the differences between groups, a frailty model using propensity scores and inverse probability of treatment weighting was used. Results- A total of 5934 patients with symptomatic large artery atherosclerotic occlusive disease were treated either with clopidogrel plus aspirin (n=2903, 49%) or aspirin (n=3031, 51%). The frequency of the primary outcome was 12% (n=353) in the clopidogrel-aspirin group and 14% (n=410) in the aspirin group. The hazards of the primary outcome with combination over aspirin only were significantly reduced in the per-protocol and as-treated analyses (hazard ratio, 0.71; 95% CI, 0.57-0.88; P=0.002 and hazard ratio, 0.81; 95% CI, 0.69-0.96; P=0.02, respectively), but there was borderline significance in the intention-to-treat analysis (hazard ratio, 0.86; 95% CI, 0.74-1.01; P=0.06). Combination therapy was beneficial for all-cause death in all analyses but did not reduce recurrent stroke. Conclusions- Compared with patients receiving aspirin monotherapy, the primary outcome seemed to occur less frequently in patients receiving dual antiplatelet therapy, which is explained mainly by the decrease of all-cause death. Since this is a nonrandomized, retrospective, observational study, our study should be cautiously interpreted.

Original languageEnglish
Pages (from-to)1184-1192
Number of pages9
JournalStroke
Volume50
Issue number5
DOIs
Publication statusPublished - 2019 May 1

Keywords

  • aspirin
  • atherosclerosis
  • cerebral infarction
  • clopidogrel
  • mortality

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

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    Kim, D., Park, J. M., Kang, K., Cho, Y. J., Hong, K. S., Lee, K. B., Park, T. H., Lee, S. J., Kim, J. G., Han, M. K., Kim, B. J., Lee, J., Cha, J. K., Kim, D. H., Nah, H. W., Kim, D. E., Ryu, W. S., Kim, J. T., Choi, K. H., ... Bae, H. J. (2019). Dual Versus Mono Antiplatelet Therapy in Large Atherosclerotic Stroke. Stroke, 50(5), 1184-1192. https://doi.org/10.1161/STROKEAHA.119.024786