Dynamic circulation and genetic exchange of a shrew-borne hantavirus, imjin virus, in the Republic of Korea

Seung Ho Lee, Won Keun Kim, Jin Sun No, Jeong Ah Kim, Jin Il Kim, Se Hun Gu, Heung Chul Kim, Terry A. Klein, Man-Seong Park, Jin Won Song

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Hantaviruses (family Bunyaviridae) are enveloped negative-sense tripartite RNA viruses. The natural hosts of hantaviruses include rodents, shrews, moles, and bats. Imjin virus (MJNV) is a shrew-borne hantavirus identified from the Ussuri white-toothed shrews (Crocidura lasiura) in the Republic of Korea (ROK) and China. We have isolated MJNV and determined its prevalence and molecular diversity in Gyeonggi province, ROK. However, the distribution and phylogeography of MJNV in other regions of ROK remain unknown. A total of 96 C. lasiura were captured from Gangwon and Gyeonggi provinces, ROK, during 2011-2014. Among them, four (4.2%) shrews were positive for anti-MJNV IgG and MJNV RNA was detected from nine (9.4%), respectively. Based on the prevalence of MJNV RNA, the preponderance of infected shrews was male and adult, consistent with the gender- and weight-specific prevalence of hantaviruses in other species. We monitored the viral load of MJNV RNA in various tissues of shrews, which would reflect the dynamic infectious status and circulation of MJNV in nature. Our phylogeographic and genomic characterization of MJNV suggested natural occurrences of recombination and reassortment in the virus population. Thus, these findings provide significant insights into the epidemiology, phylogeographic diversity, and dynamic circulation and evolution of shrew-borne hantaviruses.

Original languageEnglish
Article number44369
JournalScientific Reports
Volume7
DOIs
Publication statusPublished - 2017 Mar 15

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Shrews
Hantavirus
Republic of Korea
Viruses
RNA
Bunyaviridae
Phylogeography
RNA Viruses
Viral Load
Taiwan
Genetic Recombination
Rodentia
Epidemiology
Weights and Measures

ASJC Scopus subject areas

  • General

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Dynamic circulation and genetic exchange of a shrew-borne hantavirus, imjin virus, in the Republic of Korea. / Lee, Seung Ho; Kim, Won Keun; No, Jin Sun; Kim, Jeong Ah; Kim, Jin Il; Gu, Se Hun; Kim, Heung Chul; Klein, Terry A.; Park, Man-Seong; Song, Jin Won.

In: Scientific Reports, Vol. 7, 44369, 15.03.2017.

Research output: Contribution to journalArticle

Lee, Seung Ho ; Kim, Won Keun ; No, Jin Sun ; Kim, Jeong Ah ; Kim, Jin Il ; Gu, Se Hun ; Kim, Heung Chul ; Klein, Terry A. ; Park, Man-Seong ; Song, Jin Won. / Dynamic circulation and genetic exchange of a shrew-borne hantavirus, imjin virus, in the Republic of Korea. In: Scientific Reports. 2017 ; Vol. 7.
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