Dynamic metallization of spherical DNA via conformational transition into gold nanostructures with controlled sizes and shapes

Won Kyu Lee, Kihun Kwon, Yeonho Choi, Jae-Seung Lee

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Despite the reversible condensation properties of DNA, DNA metallization during controlled conformational transitions has been rarely investigated. We perform dynamic metallization of spherically condensed DNA nanoparticles (DNA NPs) via a globule-to-coil transition. A positively charged new Au3+ reagent is prepared via ligand-exchange of conventional complex Au3+ ions, which was used to synthesize spherically condensed DNA NPs simply based on the fundamental electrostatic and coordinative interactions between DNA and Au3+ ions. Interestingly, the size of the Au3+-condensed DNA NPs (Au3+-DNA NPs) and the type of reducing agents lead to the formation of different Au nanostructures with unprecedented morphologies (cracked NPs, bowl-shaped NPs, and small NPs), owing to the controlled conformational changes in the Au3+-DNA NPs during metallization. The condensed DNA NPs play significant roles for Au nanostructures as (1) the dynamic template for the synthesis, (2) the reservoir and supply of Au3+ for the growth, and (3) the surface stabilizer. The synthesized Au nanostructures are remarkably stable against high ionic strength and exhibit catalytic activities and excellent SERS properties. This is the first study on the morphological control and concomitant dynamic metallization of spherically condensed DNA, proposing new synthetic routes for bioinorganic nanomaterials.

Original languageEnglish
Pages (from-to)160-172
Number of pages13
JournalJournal of Colloid and Interface Science
Volume594
DOIs
Publication statusPublished - 2021 Jul 15

Keywords

  • Au
  • Catalysis
  • Conformation transition
  • DNA template
  • Dynamic metallization
  • Surface-enhanced Raman spectroscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry

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