Dynamic microcontainers as microvacuums for collecting nanomaterials after clinical treatments

Daniel S. Choi, Jungrae Park, Ke Xu, Rose Kringel, John J. Choi, In Tak Jeon, Young-geun Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We present a feasible method to collect ferromagnetic nanomaterials (FNMs) after clinical utilization by employing ferromagnetic micro-containers (MCs). The cubic MCs with dimensions of 200 micrometers have gold-coated nickel frames and were tethered such a way that they are able to remove FNMs from cells with the use of an external magnetic field. The study has been conducted in two parts: 1) enhancement of the motion of MCs in glass-based microfluidic channels filled with viscous fluids by magnetically-driven spinning MCs, i.e., 'dynamic MCs'; 2) sweeping FNMs from the cells using magnetic attractive forces between FNMs and MCs through a 'microvacuum' process. Our study shows that spinning MCs can transport better than nonspinning MCs through viscous fluids. We found that approximately 70% of FNMs internalized with human embryonic cells (HEK-293) were removed from the cells by the spinning MCs. Such in-vitro experiments suggest the possibility of resolving the issue of removing FNMs used for clinical treatments from human body after treatments.

Original languageEnglish
Article number6559034
Pages (from-to)3464-3467
Number of pages4
JournalIEEE Transactions on Magnetics
Volume49
Issue number7
DOIs
Publication statusPublished - 2013 Aug 2

Fingerprint

Nanostructured materials
Containers
Fluids
Nickel
Microfluidics
Gold
Magnetic fields
Glass

Keywords

  • Dynamic nanowires
  • ferromagnetic nanomaterials
  • microcontainer
  • microfluidics
  • microvacuum

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials

Cite this

Dynamic microcontainers as microvacuums for collecting nanomaterials after clinical treatments. / Choi, Daniel S.; Park, Jungrae; Xu, Ke; Kringel, Rose; Choi, John J.; Jeon, In Tak; Kim, Young-geun.

In: IEEE Transactions on Magnetics, Vol. 49, No. 7, 6559034, 02.08.2013, p. 3464-3467.

Research output: Contribution to journalArticle

Choi, Daniel S. ; Park, Jungrae ; Xu, Ke ; Kringel, Rose ; Choi, John J. ; Jeon, In Tak ; Kim, Young-geun. / Dynamic microcontainers as microvacuums for collecting nanomaterials after clinical treatments. In: IEEE Transactions on Magnetics. 2013 ; Vol. 49, No. 7. pp. 3464-3467.
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