Dynamic temporal change of cerebral microbleeds

Long-Term Follow-Up MRI study

Seung Hoon Lee, Soon Tae Lee, Beom Joon Kim, Hee Kwon Park, Chi Kyung Kim, Keun Hwa Jung, Jae Kyu Roh

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background: Cerebral microbleeds (MBs) are understood as an important radiologic marker of intracerebral hemorrhage. We sought to investigate the temporal changes of MBs and clinical factors associated with the changes using long-term follow-up MRI. Methods/Principal Findings: From October 2002 to July 2006, we prospectively enrolled patients with stroke or transient ischemic attack, and followed-up their brain MRIs with an interval >12 mo. We compared demographic factors, vascular risk factors, laboratory findings, and radiologic factors according to the presence or changes of MBs. A total of 224 patients successfully completed the follow-up examinations (mean, 27 months). Newly developed MBs were noted in 10 patients (6.8%) among those without MBs at baseline (n = 148), and in those with MBs at baseline (n = 76), the MB count had decreased in 11 patients (14.5%), and increased in 41 patients (53.9%). The estimated annual rate of change of MB numbers was 0.80 lesions per year in all patients, a value which became greater in those patients who exhibited MBs at baseline (MBs≥5, 5.43 lesions per year). Strokes due to small vessel occlusion and intracerebral hemorrhage, as well as white matter lesions were independently associated with an increased MB count, whereas the highest quartile of low-density lipoprotein (LDL) cholesterol was associated with a decreased MB count. Conclusion: During the follow-up period, most of MBs showed dynamic temporal change. Symptomatic or asymptomatic small vessel diseases appear to act as risk factors while in contrast, a high level of LDL cholesterol may act as a protective factor against MB increase.

Original languageEnglish
Article numbere25930
JournalPloS one
Volume6
Issue number10
DOIs
Publication statusPublished - 2011 Oct 11
Externally publishedYes

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Magnetic resonance imaging
LDL Cholesterol
Brain
lesions (animal)
Cerebral Hemorrhage
low density lipoprotein cholesterol
stroke
hemorrhage
risk factors
Stroke
Transient Ischemic Attack
blood vessels
demographic statistics
Demography
brain
vascular factor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Lee, S. H., Lee, S. T., Kim, B. J., Park, H. K., Kim, C. K., Jung, K. H., & Roh, J. K. (2011). Dynamic temporal change of cerebral microbleeds: Long-Term Follow-Up MRI study. PloS one, 6(10), [e25930]. https://doi.org/10.1371/journal.pone.0025930

Dynamic temporal change of cerebral microbleeds : Long-Term Follow-Up MRI study. / Lee, Seung Hoon; Lee, Soon Tae; Kim, Beom Joon; Park, Hee Kwon; Kim, Chi Kyung; Jung, Keun Hwa; Roh, Jae Kyu.

In: PloS one, Vol. 6, No. 10, e25930, 11.10.2011.

Research output: Contribution to journalArticle

Lee, Seung Hoon ; Lee, Soon Tae ; Kim, Beom Joon ; Park, Hee Kwon ; Kim, Chi Kyung ; Jung, Keun Hwa ; Roh, Jae Kyu. / Dynamic temporal change of cerebral microbleeds : Long-Term Follow-Up MRI study. In: PloS one. 2011 ; Vol. 6, No. 10.
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