Dysautonomia is associated with structural and functional alterations in Parkinson disease

Seok Jong Chung, Youn Jung Bae, Suhnyoung Jun, Han Soo Yoo, Seung Woo Kim, Yang Hyun Lee, Young H. Sohn, Seung Koo Lee, Jun Kyung Seong, Phil Hyu Lee

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To investigate whether the presence of autonomic dysfunction is associated with white matter and functional connectivities and the level of cognitive performance in patients with de novo Parkinson disease (PD). METHODS: Seventy-five patients with de novo PD underwent a comprehensive autonomic function test and were classified into 2 groups according to the Composite Autonomic Severity Score (CASS; 30 with moderate to severe autonomic dysfunction [CASS 4-10, PD-AUT+] and 45 without significant autonomic dysfunction [CASS 0-3, PD-AUT-]). Network-based statistics and a graph theoretical analysis were performed to assess the interregional white matter connectivity using diffusion tensor imaging. We also performed analyses of resting-state functional connectivity and compared cognitive performance between the 2 groups. RESULTS: There were no significant differences in demographic characteristics and vascular risk factors between the PD-AUT+ and PD-AUT- groups. The PD-AUT+ group showed poorer cognitive performance on frontal/executive function than the PD-AUT- group. The PD-AUT+ group exhibited severely disrupted white matter connectivity in both fronto-subcortical and posterior cortical regions, which was well correlated with the severity of autonomic dysfunction assessed by the CASS. In addition, functional connectivity within the executive control network and dorsal attention network negatively correlated with the CASS. CONCLUSIONS: Our results suggest that autonomic dysfunction is associated with disrupted white matter and functional brain connectivity as well as cognitive impairment in de novo patients with PD.

Original languageEnglish
Pages (from-to)e1456-e1467
JournalNeurology
Volume92
Issue number13
DOIs
Publication statusPublished - 2019 Mar 26

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Primary Dysautonomias
Parkinson Disease
Executive Function
Diffusion Tensor Imaging
Demography
6-chloropenicillanic acid S-sulfoxide

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Chung, S. J., Bae, Y. J., Jun, S., Yoo, H. S., Kim, S. W., Lee, Y. H., ... Lee, P. H. (2019). Dysautonomia is associated with structural and functional alterations in Parkinson disease. Neurology, 92(13), e1456-e1467. https://doi.org/10.1212/WNL.0000000000007181

Dysautonomia is associated with structural and functional alterations in Parkinson disease. / Chung, Seok Jong; Bae, Youn Jung; Jun, Suhnyoung; Yoo, Han Soo; Kim, Seung Woo; Lee, Yang Hyun; Sohn, Young H.; Lee, Seung Koo; Seong, Jun Kyung; Lee, Phil Hyu.

In: Neurology, Vol. 92, No. 13, 26.03.2019, p. e1456-e1467.

Research output: Contribution to journalArticle

Chung, SJ, Bae, YJ, Jun, S, Yoo, HS, Kim, SW, Lee, YH, Sohn, YH, Lee, SK, Seong, JK & Lee, PH 2019, 'Dysautonomia is associated with structural and functional alterations in Parkinson disease', Neurology, vol. 92, no. 13, pp. e1456-e1467. https://doi.org/10.1212/WNL.0000000000007181
Chung, Seok Jong ; Bae, Youn Jung ; Jun, Suhnyoung ; Yoo, Han Soo ; Kim, Seung Woo ; Lee, Yang Hyun ; Sohn, Young H. ; Lee, Seung Koo ; Seong, Jun Kyung ; Lee, Phil Hyu. / Dysautonomia is associated with structural and functional alterations in Parkinson disease. In: Neurology. 2019 ; Vol. 92, No. 13. pp. e1456-e1467.
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