E3 ubiquitin ligase, WWP1, interacts with AMPKα2 and down-regulates its expression in skeletal muscle C2C12 cells

Jung Ok Lee, Soo Kyung Lee, Nami Kim, Ji Hae Kim, Ga Young You, Ji Wook Moon, Sha Jie, Su Jin Kim, Yong Woo Lee, Ho Jin Kang, Yongchul Lim, Sun Hwa Park, Hyeon Soo Kim

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15 Citations (Scopus)

Abstract

Background: The role of the ubiquitin-proteasome pathway under high glucose conditions is unclear. Results: AMPKα2 interacts with WWP1, and its expression is down-regulated by the ubiquitin proteasome pathway in high glucose culture conditions in C2C12 cells. Conclusion: WWP1 down-regulates AMPKα2 expression through direct interaction in high glucose culture conditions of skeletal muscle C2C12 cells. Significance: The ubiquitin proteasome pathway may involve high glucose-induced AMPKa2 down-regulation.

Original languageEnglish
Pages (from-to)4673-4680
Number of pages8
JournalJournal of Biological Chemistry
Volume288
Issue number7
DOIs
Publication statusPublished - 2013 Feb 15

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Lee, J. O., Lee, S. K., Kim, N., Kim, J. H., You, G. Y., Moon, J. W., Jie, S., Kim, S. J., Lee, Y. W., Kang, H. J., Lim, Y., Park, S. H., & Kim, H. S. (2013). E3 ubiquitin ligase, WWP1, interacts with AMPKα2 and down-regulates its expression in skeletal muscle C2C12 cells. Journal of Biological Chemistry, 288(7), 4673-4680. https://doi.org/10.1074/jbc.M112.406009