E3 ubiquitin ligase, WWP1, interacts with AMPKα2 and down-regulates its expression in skeletal muscle C2C12 cells

Jung Ok Lee, Soo Kyung Lee, Nami Kim, Ji Hae Kim, Ga Young You, Ji Wook Moon, Sha Jie, Su Jin Kim, Yong Woo Lee, Ho Jin Kang, Yongchul Lim, Sun-Hwa Park, Hyeon Soo Kim

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: The role of the ubiquitin-proteasome pathway under high glucose conditions is unclear. Results: AMPKα2 interacts with WWP1, and its expression is down-regulated by the ubiquitin proteasome pathway in high glucose culture conditions in C2C12 cells. Conclusion: WWP1 down-regulates AMPKα2 expression through direct interaction in high glucose culture conditions of skeletal muscle C2C12 cells. Significance: The ubiquitin proteasome pathway may involve high glucose-induced AMPKa2 down-regulation.

Original languageEnglish
Pages (from-to)4673-4680
Number of pages8
JournalJournal of Biological Chemistry
Volume288
Issue number7
DOIs
Publication statusPublished - 2013 Feb 15

Fingerprint

Ubiquitin-Protein Ligases
Muscle Cells
Muscle
Skeletal Muscle
Proteasome Endopeptidase Complex
Down-Regulation
Ubiquitin
Glucose

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

E3 ubiquitin ligase, WWP1, interacts with AMPKα2 and down-regulates its expression in skeletal muscle C2C12 cells. / Lee, Jung Ok; Lee, Soo Kyung; Kim, Nami; Kim, Ji Hae; You, Ga Young; Moon, Ji Wook; Jie, Sha; Kim, Su Jin; Lee, Yong Woo; Kang, Ho Jin; Lim, Yongchul; Park, Sun-Hwa; Kim, Hyeon Soo.

In: Journal of Biological Chemistry, Vol. 288, No. 7, 15.02.2013, p. 4673-4680.

Research output: Contribution to journalArticle

Lee, JO, Lee, SK, Kim, N, Kim, JH, You, GY, Moon, JW, Jie, S, Kim, SJ, Lee, YW, Kang, HJ, Lim, Y, Park, S-H & Kim, HS 2013, 'E3 ubiquitin ligase, WWP1, interacts with AMPKα2 and down-regulates its expression in skeletal muscle C2C12 cells', Journal of Biological Chemistry, vol. 288, no. 7, pp. 4673-4680. https://doi.org/10.1074/jbc.M112.406009
Lee, Jung Ok ; Lee, Soo Kyung ; Kim, Nami ; Kim, Ji Hae ; You, Ga Young ; Moon, Ji Wook ; Jie, Sha ; Kim, Su Jin ; Lee, Yong Woo ; Kang, Ho Jin ; Lim, Yongchul ; Park, Sun-Hwa ; Kim, Hyeon Soo. / E3 ubiquitin ligase, WWP1, interacts with AMPKα2 and down-regulates its expression in skeletal muscle C2C12 cells. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 7. pp. 4673-4680.
@article{c2b88fd809854a6aba459de3507baa7f,
title = "E3 ubiquitin ligase, WWP1, interacts with AMPKα2 and down-regulates its expression in skeletal muscle C2C12 cells",
abstract = "Background: The role of the ubiquitin-proteasome pathway under high glucose conditions is unclear. Results: AMPKα2 interacts with WWP1, and its expression is down-regulated by the ubiquitin proteasome pathway in high glucose culture conditions in C2C12 cells. Conclusion: WWP1 down-regulates AMPKα2 expression through direct interaction in high glucose culture conditions of skeletal muscle C2C12 cells. Significance: The ubiquitin proteasome pathway may involve high glucose-induced AMPKa2 down-regulation.",
author = "Lee, {Jung Ok} and Lee, {Soo Kyung} and Nami Kim and Kim, {Ji Hae} and You, {Ga Young} and Moon, {Ji Wook} and Sha Jie and Kim, {Su Jin} and Lee, {Yong Woo} and Kang, {Ho Jin} and Yongchul Lim and Sun-Hwa Park and Kim, {Hyeon Soo}",
year = "2013",
month = "2",
day = "15",
doi = "10.1074/jbc.M112.406009",
language = "English",
volume = "288",
pages = "4673--4680",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "7",

}

TY - JOUR

T1 - E3 ubiquitin ligase, WWP1, interacts with AMPKα2 and down-regulates its expression in skeletal muscle C2C12 cells

AU - Lee, Jung Ok

AU - Lee, Soo Kyung

AU - Kim, Nami

AU - Kim, Ji Hae

AU - You, Ga Young

AU - Moon, Ji Wook

AU - Jie, Sha

AU - Kim, Su Jin

AU - Lee, Yong Woo

AU - Kang, Ho Jin

AU - Lim, Yongchul

AU - Park, Sun-Hwa

AU - Kim, Hyeon Soo

PY - 2013/2/15

Y1 - 2013/2/15

N2 - Background: The role of the ubiquitin-proteasome pathway under high glucose conditions is unclear. Results: AMPKα2 interacts with WWP1, and its expression is down-regulated by the ubiquitin proteasome pathway in high glucose culture conditions in C2C12 cells. Conclusion: WWP1 down-regulates AMPKα2 expression through direct interaction in high glucose culture conditions of skeletal muscle C2C12 cells. Significance: The ubiquitin proteasome pathway may involve high glucose-induced AMPKa2 down-regulation.

AB - Background: The role of the ubiquitin-proteasome pathway under high glucose conditions is unclear. Results: AMPKα2 interacts with WWP1, and its expression is down-regulated by the ubiquitin proteasome pathway in high glucose culture conditions in C2C12 cells. Conclusion: WWP1 down-regulates AMPKα2 expression through direct interaction in high glucose culture conditions of skeletal muscle C2C12 cells. Significance: The ubiquitin proteasome pathway may involve high glucose-induced AMPKa2 down-regulation.

UR - http://www.scopus.com/inward/record.url?scp=84874077399&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874077399&partnerID=8YFLogxK

U2 - 10.1074/jbc.M112.406009

DO - 10.1074/jbc.M112.406009

M3 - Article

C2 - 23293026

AN - SCOPUS:84874077399

VL - 288

SP - 4673

EP - 4680

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 7

ER -