TY - JOUR
T1 - Early abnormalities of cardiovascular structure and function in middle-aged korean adults with prehypertension
T2 - The Korean genome epidemiology study
AU - Kim, Seong Hwan
AU - Cho, Goo Yeong
AU - Baik, Inkyung
AU - Lim, Sang Yup
AU - Choi, Cheol Ung
AU - Lim, Hong Euy
AU - Kim, Eung Ju
AU - Park, Chang Gyu
AU - Park, Juri
AU - Kim, Jinyoung
AU - Shin, Chol
N1 - Funding Information:
acknowledgments: This study was supported by grants (2007-090-091-4854-300 and 2008-e00169-00) from the Korean Centers for Disease Control and Prevention, and partially supported by a grant (K0821491) from the Korea university Medical Institute.
PY - 2011/2
Y1 - 2011/2
N2 - BackgroundPrehypertension is associated with increased cardiovascular morbidity and mortality. However, there are few population-based studies on the changes of cardiovascular structure and function that characterize prehypertension. The aim of this study was to assess whether prehypertension is associated with abnormalities of cardiovascular structure and function in the general Korean population.MethodsWe analyzed the cross-sectional relationships between prehypertension and cardiovascular structure and function in a sample from the Korean Genome Epidemiology Study. A total of 1,671 individuals (54.5% women; mean age: 53 6 years) without hypertension and diabetes mellitus were enrolled. Cardiovascular structure and function were assessed by conventional echocardiography, tissue Doppler imaging (TDI), carotid ultrasonography, and pulse wave velocity (PWV).ResultsThe left ventricular (LV) mass index was significantly higher in subjects with prehypertension than in those with normotension (41 8g/m 2.7 vs. 38 7g/m2.7, P< 0.001). LV diastolic parameters, such as the E/A ratio, TDI E a velocity, and E/E a ratio, were also impaired in subjects with prehypertension (all P 0.001). Compared with normotension, prehypertension was characterized by a significantly higher common carotid artery intima-media thickness and a higher brachial-ankle PWV (all P <0.001). These abnormalities of cardiovascular structure and function remained significant after adjustment for covariates.ConclusionsIn this population-based cohort, we found that subtle alterations in cardiovascular structure and function were already present at the prehypertensive stage. Whether such subtle alterations convey an increased risk of cardiovascular events and whether the changes are reversible with treatment warrant further study.
AB - BackgroundPrehypertension is associated with increased cardiovascular morbidity and mortality. However, there are few population-based studies on the changes of cardiovascular structure and function that characterize prehypertension. The aim of this study was to assess whether prehypertension is associated with abnormalities of cardiovascular structure and function in the general Korean population.MethodsWe analyzed the cross-sectional relationships between prehypertension and cardiovascular structure and function in a sample from the Korean Genome Epidemiology Study. A total of 1,671 individuals (54.5% women; mean age: 53 6 years) without hypertension and diabetes mellitus were enrolled. Cardiovascular structure and function were assessed by conventional echocardiography, tissue Doppler imaging (TDI), carotid ultrasonography, and pulse wave velocity (PWV).ResultsThe left ventricular (LV) mass index was significantly higher in subjects with prehypertension than in those with normotension (41 8g/m 2.7 vs. 38 7g/m2.7, P< 0.001). LV diastolic parameters, such as the E/A ratio, TDI E a velocity, and E/E a ratio, were also impaired in subjects with prehypertension (all P 0.001). Compared with normotension, prehypertension was characterized by a significantly higher common carotid artery intima-media thickness and a higher brachial-ankle PWV (all P <0.001). These abnormalities of cardiovascular structure and function remained significant after adjustment for covariates.ConclusionsIn this population-based cohort, we found that subtle alterations in cardiovascular structure and function were already present at the prehypertensive stage. Whether such subtle alterations convey an increased risk of cardiovascular events and whether the changes are reversible with treatment warrant further study.
KW - arterial pulse wave velocity
KW - blood pressure
KW - carotid intima- media thickness
KW - diastolic function
KW - hypertension
KW - left ventricular mass
KW - prehypertension
KW - tissue Doppler imaging
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U2 - 10.1038/ajh.2010.213
DO - 10.1038/ajh.2010.213
M3 - Article
C2 - 20885368
AN - SCOPUS:78751607332
VL - 24
SP - 218
EP - 224
JO - American Journal of Hypertension
JF - American Journal of Hypertension
SN - 0895-7061
IS - 2
ER -