Early abnormalities of cardiovascular structure and function in middle-aged korean adults with prehypertension: The Korean genome epidemiology study

Seong Hwan Kim, Goo Yeong Cho, Inkyung Baik, Sang Yeob Lim, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Juri Park, Jinyoung Kim, Chol Shin

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

BackgroundPrehypertension is associated with increased cardiovascular morbidity and mortality. However, there are few population-based studies on the changes of cardiovascular structure and function that characterize prehypertension. The aim of this study was to assess whether prehypertension is associated with abnormalities of cardiovascular structure and function in the general Korean population.MethodsWe analyzed the cross-sectional relationships between prehypertension and cardiovascular structure and function in a sample from the Korean Genome Epidemiology Study. A total of 1,671 individuals (54.5% women; mean age: 53 6 years) without hypertension and diabetes mellitus were enrolled. Cardiovascular structure and function were assessed by conventional echocardiography, tissue Doppler imaging (TDI), carotid ultrasonography, and pulse wave velocity (PWV).ResultsThe left ventricular (LV) mass index was significantly higher in subjects with prehypertension than in those with normotension (41 8g/m 2.7 vs. 38 7g/m2.7, P< 0.001). LV diastolic parameters, such as the E/A ratio, TDI E a velocity, and E/E a ratio, were also impaired in subjects with prehypertension (all P 0.001). Compared with normotension, prehypertension was characterized by a significantly higher common carotid artery intima-media thickness and a higher brachial-ankle PWV (all P <0.001). These abnormalities of cardiovascular structure and function remained significant after adjustment for covariates.ConclusionsIn this population-based cohort, we found that subtle alterations in cardiovascular structure and function were already present at the prehypertensive stage. Whether such subtle alterations convey an increased risk of cardiovascular events and whether the changes are reversible with treatment warrant further study.

Original languageEnglish
Pages (from-to)218-224
Number of pages7
JournalAmerican Journal of Hypertension
Volume24
Issue number2
DOIs
Publication statusPublished - 2011 Feb 1

Keywords

  • arterial pulse wave velocity
  • blood pressure
  • carotid intima- media thickness
  • diastolic function
  • hypertension
  • left ventricular mass
  • prehypertension
  • tissue Doppler imaging

ASJC Scopus subject areas

  • Internal Medicine

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