Early Changes in the Serotype Distribution of Invasive Pneumococcal Isolates from Children after the Introduction of Extended-valent Pneumococcal Conjugate Vaccines in Korea, 2011-2013

Eun Young Cho, Eun Hwa Choi, Jin Han Kang, Kyung Hyo Kim, Dong Soo Kim, Yae Jean Kim, Young Min Ahn, Byung Wook Eun, Sung Hee Oh, Sung Ho Cha, Hye Kyung Cho, Young Jin Hong, Kwang Nam Kim, Nam Hee Kim, Yun Kyung Kim, Jong Hyun Kim, Hyunju Lee, Taekjin Lee, Hwang Min Kim, Kun Song LeeChun Soo Kim, Su Eun Park, Young Mi Kim, Chi Eun Oh, Sang Hyuk Ma, Dae Sun Jo, Young Youn Choi, Jina Lee, Geun Ryang Bae, Ok Park, Young Joon Park, Eun Seong Kim, Hoan Jong Lee

Research output: Contribution to journalArticle

Abstract

This study was performed to measure early changes in the serotype distribution of pneumococci isolated from children with invasive disease during the 3-year period following the introduction of 10- and 13-valent pneumococcal conjugate vaccines (PCVs) in Korea. From January 2011 to December 2013 at 25 hospitals located throughout Korea, pneumococci were isolated among children who had invasive pneumococcal disease (IPD). Serotypes were determined using the Quellung reaction, and the change in serotype distribution was analyzed. Seventy-five cases of IPD were included. Eighty percent of patients were aged 3-59 months, and 32% had a comorbidity that increased the risk of pneumococcal infection. The most common serotypes were 19A (32.0%), 10A (8.0%), and 15C (6.7%). The PCV7 serotypes (4, 6B, 9V, 14, 18C, 19F, 23F, and 6A) accounted for 14.7% of the total isolates and the PCV13 minus PCV7 types (1, 3, 5, 7F and 19A) accounted for 32.0% of the total isolates. Serotype 19A was the only serotype in the PCV13 minus PCV7 group. The proportion of serotype 19A showed decreasing tendency from 37.5% in 2011 to 22.2% in 2013 (P = 0.309), while the proportion of non-PCV13 types showed increasing tendency from 45.8% in 2011 to 72.2% in 2013 (P = 0.108). Shortly after the introduction of extended-valent PCVs in Korea, serotype 19A continued to be the most common serotype causing IPD in children. Subsequently, the proportion of 19A decreased, and non-vaccine serotypes emerged as an important cause of IPD. The impact of extended-valent vaccines must be continuously monitored.

Original languageEnglish
Pages (from-to)1082-1088
Number of pages7
JournalJournal of Korean Medical Science
Volume31
Issue number7
DOIs
Publication statusPublished - 2016 Jul 1

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Conjugate Vaccines
Pneumococcal Vaccines
Korea
Streptococcus pneumoniae
Serogroup
Pneumococcal Infections
Comorbidity
Vaccines

Keywords

  • Pneumococcal Vaccines
  • Serotype
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Early Changes in the Serotype Distribution of Invasive Pneumococcal Isolates from Children after the Introduction of Extended-valent Pneumococcal Conjugate Vaccines in Korea, 2011-2013. / Cho, Eun Young; Choi, Eun Hwa; Kang, Jin Han; Kim, Kyung Hyo; Kim, Dong Soo; Kim, Yae Jean; Ahn, Young Min; Eun, Byung Wook; Oh, Sung Hee; Cha, Sung Ho; Cho, Hye Kyung; Hong, Young Jin; Kim, Kwang Nam; Kim, Nam Hee; Kim, Yun Kyung; Kim, Jong Hyun; Lee, Hyunju; Lee, Taekjin; Kim, Hwang Min; Lee, Kun Song; Kim, Chun Soo; Park, Su Eun; Kim, Young Mi; Oh, Chi Eun; Ma, Sang Hyuk; Jo, Dae Sun; Choi, Young Youn; Lee, Jina; Bae, Geun Ryang; Park, Ok; Park, Young Joon; Kim, Eun Seong; Lee, Hoan Jong.

In: Journal of Korean Medical Science, Vol. 31, No. 7, 01.07.2016, p. 1082-1088.

Research output: Contribution to journalArticle

Cho, EY, Choi, EH, Kang, JH, Kim, KH, Kim, DS, Kim, YJ, Ahn, YM, Eun, BW, Oh, SH, Cha, SH, Cho, HK, Hong, YJ, Kim, KN, Kim, NH, Kim, YK, Kim, JH, Lee, H, Lee, T, Kim, HM, Lee, KS, Kim, CS, Park, SE, Kim, YM, Oh, CE, Ma, SH, Jo, DS, Choi, YY, Lee, J, Bae, GR, Park, O, Park, YJ, Kim, ES & Lee, HJ 2016, 'Early Changes in the Serotype Distribution of Invasive Pneumococcal Isolates from Children after the Introduction of Extended-valent Pneumococcal Conjugate Vaccines in Korea, 2011-2013', Journal of Korean Medical Science, vol. 31, no. 7, pp. 1082-1088. https://doi.org/10.3346/jkms.2016.31.7.1082
Cho, Eun Young ; Choi, Eun Hwa ; Kang, Jin Han ; Kim, Kyung Hyo ; Kim, Dong Soo ; Kim, Yae Jean ; Ahn, Young Min ; Eun, Byung Wook ; Oh, Sung Hee ; Cha, Sung Ho ; Cho, Hye Kyung ; Hong, Young Jin ; Kim, Kwang Nam ; Kim, Nam Hee ; Kim, Yun Kyung ; Kim, Jong Hyun ; Lee, Hyunju ; Lee, Taekjin ; Kim, Hwang Min ; Lee, Kun Song ; Kim, Chun Soo ; Park, Su Eun ; Kim, Young Mi ; Oh, Chi Eun ; Ma, Sang Hyuk ; Jo, Dae Sun ; Choi, Young Youn ; Lee, Jina ; Bae, Geun Ryang ; Park, Ok ; Park, Young Joon ; Kim, Eun Seong ; Lee, Hoan Jong. / Early Changes in the Serotype Distribution of Invasive Pneumococcal Isolates from Children after the Introduction of Extended-valent Pneumococcal Conjugate Vaccines in Korea, 2011-2013. In: Journal of Korean Medical Science. 2016 ; Vol. 31, No. 7. pp. 1082-1088.
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abstract = "This study was performed to measure early changes in the serotype distribution of pneumococci isolated from children with invasive disease during the 3-year period following the introduction of 10- and 13-valent pneumococcal conjugate vaccines (PCVs) in Korea. From January 2011 to December 2013 at 25 hospitals located throughout Korea, pneumococci were isolated among children who had invasive pneumococcal disease (IPD). Serotypes were determined using the Quellung reaction, and the change in serotype distribution was analyzed. Seventy-five cases of IPD were included. Eighty percent of patients were aged 3-59 months, and 32{\%} had a comorbidity that increased the risk of pneumococcal infection. The most common serotypes were 19A (32.0{\%}), 10A (8.0{\%}), and 15C (6.7{\%}). The PCV7 serotypes (4, 6B, 9V, 14, 18C, 19F, 23F, and 6A) accounted for 14.7{\%} of the total isolates and the PCV13 minus PCV7 types (1, 3, 5, 7F and 19A) accounted for 32.0{\%} of the total isolates. Serotype 19A was the only serotype in the PCV13 minus PCV7 group. The proportion of serotype 19A showed decreasing tendency from 37.5{\%} in 2011 to 22.2{\%} in 2013 (P = 0.309), while the proportion of non-PCV13 types showed increasing tendency from 45.8{\%} in 2011 to 72.2{\%} in 2013 (P = 0.108). Shortly after the introduction of extended-valent PCVs in Korea, serotype 19A continued to be the most common serotype causing IPD in children. Subsequently, the proportion of 19A decreased, and non-vaccine serotypes emerged as an important cause of IPD. The impact of extended-valent vaccines must be continuously monitored.",
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AU - Kim, Kyung Hyo

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AU - Lee, Hyunju

AU - Lee, Taekjin

AU - Kim, Hwang Min

AU - Lee, Kun Song

AU - Kim, Chun Soo

AU - Park, Su Eun

AU - Kim, Young Mi

AU - Oh, Chi Eun

AU - Ma, Sang Hyuk

AU - Jo, Dae Sun

AU - Choi, Young Youn

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