Early electrodiagnostic features of upper extremity sensory nerves can differentiate axonal Guillain-Barré syndrome from acute inflammatory demyelinating polyneuropathy

Yong Seo Koo, Ha Young Shin, Jong Kuk Kim, Tai Seung Nam, Kyong Jin Shin, Jong Seok Bae, Bum Chun Suh, Jeeyoung Oh, Byeol A. Yoon, Byung Jo Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background and Purpose Serial nerve conduction studies (NCSs) are recommended for differentiating axonal and demyelinating Guillain-Barré syndrome (GBS), but this approach is not suitable for early diagnoses. This study was designed to identify possible NCS parameters for differentiating GBS subtypes. Methods We retrospectively reviewed the medical records of 70 patients with GBS who underwent NCS within 10 days of symptom onset. Patients with axonal GBS and acute inflammatory demyelinating polyneuropathy (AIDP) were selected based on clinical characteristics and serial NCSs. An antiganglioside antibody study was used to increase the diagnostic certainty. Results The amplitudes of median and ulnar nerve sensory nerve action potentials (SNAPs) were significantly smaller in the AIDP group than in the axonal-GBS group. Classification and regression-tree analysis revealed that the distal ulnar sensory nerve SNAP amplitude was the best predictor of axonal GBS. Conclusions Early upper extremity sensory NCS findings are helpful in differentiating axonal-GBS patients with antiganglioside antibodies from AIDP patients.

Original languageEnglish
Pages (from-to)495-501
Number of pages7
JournalJournal of Clinical Neurology (Korea)
Volume12
Issue number4
DOIs
Publication statusPublished - 2016 Oct 1

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Guillain-Barre Syndrome
Upper Extremity
Neural Conduction
Ulnar Nerve
Action Potentials
Antibodies
Median Nerve
Medical Records
Early Diagnosis
Regression Analysis

Keywords

  • Acute inflammatory demyelinating polyneuropathy
  • Early diagnosis
  • Electrodiagnosis
  • Guillain-Barré syndrome
  • Neural conduction

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Early electrodiagnostic features of upper extremity sensory nerves can differentiate axonal Guillain-Barré syndrome from acute inflammatory demyelinating polyneuropathy. / Koo, Yong Seo; Shin, Ha Young; Kim, Jong Kuk; Nam, Tai Seung; Shin, Kyong Jin; Bae, Jong Seok; Suh, Bum Chun; Oh, Jeeyoung; Yoon, Byeol A.; Kim, Byung Jo.

In: Journal of Clinical Neurology (Korea), Vol. 12, No. 4, 01.10.2016, p. 495-501.

Research output: Contribution to journalArticle

Koo, Yong Seo ; Shin, Ha Young ; Kim, Jong Kuk ; Nam, Tai Seung ; Shin, Kyong Jin ; Bae, Jong Seok ; Suh, Bum Chun ; Oh, Jeeyoung ; Yoon, Byeol A. ; Kim, Byung Jo. / Early electrodiagnostic features of upper extremity sensory nerves can differentiate axonal Guillain-Barré syndrome from acute inflammatory demyelinating polyneuropathy. In: Journal of Clinical Neurology (Korea). 2016 ; Vol. 12, No. 4. pp. 495-501.
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N2 - Background and Purpose Serial nerve conduction studies (NCSs) are recommended for differentiating axonal and demyelinating Guillain-Barré syndrome (GBS), but this approach is not suitable for early diagnoses. This study was designed to identify possible NCS parameters for differentiating GBS subtypes. Methods We retrospectively reviewed the medical records of 70 patients with GBS who underwent NCS within 10 days of symptom onset. Patients with axonal GBS and acute inflammatory demyelinating polyneuropathy (AIDP) were selected based on clinical characteristics and serial NCSs. An antiganglioside antibody study was used to increase the diagnostic certainty. Results The amplitudes of median and ulnar nerve sensory nerve action potentials (SNAPs) were significantly smaller in the AIDP group than in the axonal-GBS group. Classification and regression-tree analysis revealed that the distal ulnar sensory nerve SNAP amplitude was the best predictor of axonal GBS. Conclusions Early upper extremity sensory NCS findings are helpful in differentiating axonal-GBS patients with antiganglioside antibodies from AIDP patients.

AB - Background and Purpose Serial nerve conduction studies (NCSs) are recommended for differentiating axonal and demyelinating Guillain-Barré syndrome (GBS), but this approach is not suitable for early diagnoses. This study was designed to identify possible NCS parameters for differentiating GBS subtypes. Methods We retrospectively reviewed the medical records of 70 patients with GBS who underwent NCS within 10 days of symptom onset. Patients with axonal GBS and acute inflammatory demyelinating polyneuropathy (AIDP) were selected based on clinical characteristics and serial NCSs. An antiganglioside antibody study was used to increase the diagnostic certainty. Results The amplitudes of median and ulnar nerve sensory nerve action potentials (SNAPs) were significantly smaller in the AIDP group than in the axonal-GBS group. Classification and regression-tree analysis revealed that the distal ulnar sensory nerve SNAP amplitude was the best predictor of axonal GBS. Conclusions Early upper extremity sensory NCS findings are helpful in differentiating axonal-GBS patients with antiganglioside antibodies from AIDP patients.

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