Early Prediction of Periventricular Leukomalacia Using Quantitative Texture Analysis of Serial Cranial Ultrasound Scans in Very Preterm Infants

Hye Na Jung, Sang-Il Suh, Arim Park, Gun ha Kim, Inseon Ryoo

Research output: Contribution to journalArticle

Abstract

We compared texture parameters of serial cranial ultrasound (cUS) images of periventricular leukomalacia (PVL) and normal periventricular echogenicity (PVE) in very preterm infants and evaluated the early predictive values of texture analysis (TA) for PVL. Ten individuals with PVL and 10 control individuals with PVE assessed with an initial cUS within 1 wk of birth and follow-up cUS at 2–3 and 4–6 wk of life were included. TA was performed on the region of interest of PVE at the parieto-occipital area on serial cUS. Opposite changes in variance were obtained between the first two cUS sessions in both groups (p = 0.017 in PVL and p = 0.005 in PVE). The variance-to-mean ratio (VMR) between the second and first cUS sessions differed (p = 0.016) and reliably stratified the groups (area under the receiver operating characteristic curve: 0.820, 95% confidence interval: 0.587–1.000, sensitivity: 100%, specificity: 60%). TA of serial cUS helps to predict PVL within 3 wk of life.

Original languageEnglish
JournalUltrasound in Medicine and Biology
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Periventricular Leukomalacia
Premature Infants
textures
predictions
confidence
ROC Curve
receivers
intervals
Parturition
sensitivity
Confidence Intervals
curves
Sensitivity and Specificity

Keywords

  • Index of dispersion
  • Periventricular leukomalacia
  • Preterm infant
  • Quantitative texture analysis
  • Serial cranial ultrasound
  • Variance

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics

Cite this

@article{28e66b29622a4972920cda6199c40085,
title = "Early Prediction of Periventricular Leukomalacia Using Quantitative Texture Analysis of Serial Cranial Ultrasound Scans in Very Preterm Infants",
abstract = "We compared texture parameters of serial cranial ultrasound (cUS) images of periventricular leukomalacia (PVL) and normal periventricular echogenicity (PVE) in very preterm infants and evaluated the early predictive values of texture analysis (TA) for PVL. Ten individuals with PVL and 10 control individuals with PVE assessed with an initial cUS within 1 wk of birth and follow-up cUS at 2–3 and 4–6 wk of life were included. TA was performed on the region of interest of PVE at the parieto-occipital area on serial cUS. Opposite changes in variance were obtained between the first two cUS sessions in both groups (p = 0.017 in PVL and p = 0.005 in PVE). The variance-to-mean ratio (VMR) between the second and first cUS sessions differed (p = 0.016) and reliably stratified the groups (area under the receiver operating characteristic curve: 0.820, 95{\%} confidence interval: 0.587–1.000, sensitivity: 100{\%}, specificity: 60{\%}). TA of serial cUS helps to predict PVL within 3 wk of life.",
keywords = "Index of dispersion, Periventricular leukomalacia, Preterm infant, Quantitative texture analysis, Serial cranial ultrasound, Variance",
author = "Jung, {Hye Na} and Sang-Il Suh and Arim Park and Kim, {Gun ha} and Inseon Ryoo",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.ultrasmedbio.2019.06.413",
language = "English",
journal = "Ultrasound in Medicine and Biology",
issn = "0301-5629",
publisher = "Elsevier USA",

}

TY - JOUR

T1 - Early Prediction of Periventricular Leukomalacia Using Quantitative Texture Analysis of Serial Cranial Ultrasound Scans in Very Preterm Infants

AU - Jung, Hye Na

AU - Suh, Sang-Il

AU - Park, Arim

AU - Kim, Gun ha

AU - Ryoo, Inseon

PY - 2019/1/1

Y1 - 2019/1/1

N2 - We compared texture parameters of serial cranial ultrasound (cUS) images of periventricular leukomalacia (PVL) and normal periventricular echogenicity (PVE) in very preterm infants and evaluated the early predictive values of texture analysis (TA) for PVL. Ten individuals with PVL and 10 control individuals with PVE assessed with an initial cUS within 1 wk of birth and follow-up cUS at 2–3 and 4–6 wk of life were included. TA was performed on the region of interest of PVE at the parieto-occipital area on serial cUS. Opposite changes in variance were obtained between the first two cUS sessions in both groups (p = 0.017 in PVL and p = 0.005 in PVE). The variance-to-mean ratio (VMR) between the second and first cUS sessions differed (p = 0.016) and reliably stratified the groups (area under the receiver operating characteristic curve: 0.820, 95% confidence interval: 0.587–1.000, sensitivity: 100%, specificity: 60%). TA of serial cUS helps to predict PVL within 3 wk of life.

AB - We compared texture parameters of serial cranial ultrasound (cUS) images of periventricular leukomalacia (PVL) and normal periventricular echogenicity (PVE) in very preterm infants and evaluated the early predictive values of texture analysis (TA) for PVL. Ten individuals with PVL and 10 control individuals with PVE assessed with an initial cUS within 1 wk of birth and follow-up cUS at 2–3 and 4–6 wk of life were included. TA was performed on the region of interest of PVE at the parieto-occipital area on serial cUS. Opposite changes in variance were obtained between the first two cUS sessions in both groups (p = 0.017 in PVL and p = 0.005 in PVE). The variance-to-mean ratio (VMR) between the second and first cUS sessions differed (p = 0.016) and reliably stratified the groups (area under the receiver operating characteristic curve: 0.820, 95% confidence interval: 0.587–1.000, sensitivity: 100%, specificity: 60%). TA of serial cUS helps to predict PVL within 3 wk of life.

KW - Index of dispersion

KW - Periventricular leukomalacia

KW - Preterm infant

KW - Quantitative texture analysis

KW - Serial cranial ultrasound

KW - Variance

UR - http://www.scopus.com/inward/record.url?scp=85069593492&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85069593492&partnerID=8YFLogxK

U2 - 10.1016/j.ultrasmedbio.2019.06.413

DO - 10.1016/j.ultrasmedbio.2019.06.413

M3 - Article

AN - SCOPUS:85069593492

JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

SN - 0301-5629

ER -