Ecology of H3 avian influenza viruses in Korea and assessment of their pathogenic potentials

Min Suk Song, Taek Kyu Oh, Ho Jin Moon, Dai Woon Yoo, Eun Ho Lee, Jong Soo Lee, Chul Jung Kim, Gi Jo Yoo, Hyunggee Kim, Young Ki Choi

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

To determine the genetic origins of novel H3 avian influenza viruses of chickens and ducks in Korea, genetic characterization of H3 avian influenza viruses isolated from live poultry markets and migratory aquatic birds in South Korea during 2004-2006 was conducted. Phylogenetic analysis revealed that at least four novel genotypes of H3N2 and two genotypes of H3N6 avian influenza viruses were co-circulating in backyard poultry of Korea. The viruses were reassortants between H9N2 viruses of Korean chickens and unknown influenza viruses of migratory birds. Genetic comparison of H3 viruses from live bird markets with those from wild bird isolates revealed that certain gene segments of wild bird isolates are related closely to those of Korean group H9N2 viruses isolated from live poultry markets in 2003. Furthermore, animal-challenge studies demonstrated that the pathogenicity of certain avian H3 influenza viruses was altered due to reassortment, leading to H3 avian influenza viruses in Korea that can potentially expand their host range to include mammals. These studies emphasize the continuing need to monitor backyard poultry at live poultry markets to better understand interspecies transmission and the emergence of novel influenza viruses that have the potential to infect humans.

Original languageEnglish
Pages (from-to)949-957
Number of pages9
JournalJournal of General Virology
Volume89
Issue number4
DOIs
Publication statusPublished - 2008 Apr 1

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Influenza in Birds
Korea
Ecology
Orthomyxoviridae
Poultry
Birds
H9N2 Subtype Influenza A Virus
Chickens
Reassortant Viruses
Genotype
Republic of Korea
Ducks
Host Specificity
Virulence
Mammals
Viruses
Genes

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Song, M. S., Oh, T. K., Moon, H. J., Yoo, D. W., Lee, E. H., Lee, J. S., ... Choi, Y. K. (2008). Ecology of H3 avian influenza viruses in Korea and assessment of their pathogenic potentials. Journal of General Virology, 89(4), 949-957. https://doi.org/10.1099/vir.0.83462-0

Ecology of H3 avian influenza viruses in Korea and assessment of their pathogenic potentials. / Song, Min Suk; Oh, Taek Kyu; Moon, Ho Jin; Yoo, Dai Woon; Lee, Eun Ho; Lee, Jong Soo; Kim, Chul Jung; Yoo, Gi Jo; Kim, Hyunggee; Choi, Young Ki.

In: Journal of General Virology, Vol. 89, No. 4, 01.04.2008, p. 949-957.

Research output: Contribution to journalArticle

Song, MS, Oh, TK, Moon, HJ, Yoo, DW, Lee, EH, Lee, JS, Kim, CJ, Yoo, GJ, Kim, H & Choi, YK 2008, 'Ecology of H3 avian influenza viruses in Korea and assessment of their pathogenic potentials', Journal of General Virology, vol. 89, no. 4, pp. 949-957. https://doi.org/10.1099/vir.0.83462-0
Song, Min Suk ; Oh, Taek Kyu ; Moon, Ho Jin ; Yoo, Dai Woon ; Lee, Eun Ho ; Lee, Jong Soo ; Kim, Chul Jung ; Yoo, Gi Jo ; Kim, Hyunggee ; Choi, Young Ki. / Ecology of H3 avian influenza viruses in Korea and assessment of their pathogenic potentials. In: Journal of General Virology. 2008 ; Vol. 89, No. 4. pp. 949-957.
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