Ectopic cardiovascular fat in middle-aged men: Effects of race/ethnicity, overall and central adiposity. The ERA JUMP study

S. R. El Khoudary, Chol Shin, K. Masaki, K. Miura, M. Budoff, D. Edmundowicz, S. Kadowaki, E. Barinas-Mitchell, A. El-Saed, A. Fujiyoshi, R. W. Evans, T. Hisamatsu, T. Ohkubo, B. J. Willcox, L. H. Kuller, H. Ueshima, A. Sekikawa

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background/objectives:Higher volumes of ectopic cardiovascular fat (ECF) are associated with greater risk of coronary heart disease (CHD). Identifying factors that are associated with ECF volumes may lead to new preventive efforts to reduce risk of CHD. Significant racial/ethnic differences exist for overall and central adiposity measures, which are known to be associated with ECF volumes. Whether racial/ethnic differences also exist for ECF volumes and their associations with these adiposity measures remain unclear.Subjects/methods:Body mass index (BMI), computerized tomography-measured ECF volumes (epicardial, pericardial and their summation) and visceral adipose tissue (VAT) were examined in a community-based sample of 1199 middle-aged men (24.2% Caucasians, 7.0% African-Americans, 23.6% Japanese-Americans, 22.0% Japanese, 23.2% Koreans).Results:Significant racial/ethnic differences existed in ECF volumes and their relationships with BMI and VAT. ECF volumes were the highest among Japanese-Americans and the lowest among African-Americans. The associations of BMI and VAT with ECF differed by racial/ethnic groups. Compared with Caucasians, for each 1-unit increase in BMI, African-Americans had lower, whereas Koreans had higher increases in ECF volumes (P-values<0.05 for both). Meanwhile, compared with Caucasians, for each 1-unit increase in log-transformed VAT, African-Americans, Japanese-Americans and Japanese had similar increases, whereas Koreans had a lower increase in ECF volumes (P-value<0.05).Conclusions:Racial/ethnic groups differed in their propensity to accumulate ECF at increasing level of overall and central adiposity. Future studies should evaluate whether reducing central adiposity or overall weight will decrease ECF volumes more in certain racial/ethnic groups. Evaluating these questions might help in designing race-specific prevention strategy of CHD risk associated with higher ECF.

Original languageEnglish
Pages (from-to)488-494
Number of pages7
JournalInternational Journal of Obesity
Volume39
Issue number3
DOIs
Publication statusPublished - 2015 Mar 12

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Adiposity
Fats
Intra-Abdominal Fat
African Americans
Asian Americans
Body Mass Index
Ethnic Groups
Coronary Disease
Tomography

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism

Cite this

Ectopic cardiovascular fat in middle-aged men : Effects of race/ethnicity, overall and central adiposity. The ERA JUMP study. / El Khoudary, S. R.; Shin, Chol; Masaki, K.; Miura, K.; Budoff, M.; Edmundowicz, D.; Kadowaki, S.; Barinas-Mitchell, E.; El-Saed, A.; Fujiyoshi, A.; Evans, R. W.; Hisamatsu, T.; Ohkubo, T.; Willcox, B. J.; Kuller, L. H.; Ueshima, H.; Sekikawa, A.

In: International Journal of Obesity, Vol. 39, No. 3, 12.03.2015, p. 488-494.

Research output: Contribution to journalArticle

El Khoudary, SR, Shin, C, Masaki, K, Miura, K, Budoff, M, Edmundowicz, D, Kadowaki, S, Barinas-Mitchell, E, El-Saed, A, Fujiyoshi, A, Evans, RW, Hisamatsu, T, Ohkubo, T, Willcox, BJ, Kuller, LH, Ueshima, H & Sekikawa, A 2015, 'Ectopic cardiovascular fat in middle-aged men: Effects of race/ethnicity, overall and central adiposity. The ERA JUMP study', International Journal of Obesity, vol. 39, no. 3, pp. 488-494. https://doi.org/10.1038/ijo.2014.154
El Khoudary, S. R. ; Shin, Chol ; Masaki, K. ; Miura, K. ; Budoff, M. ; Edmundowicz, D. ; Kadowaki, S. ; Barinas-Mitchell, E. ; El-Saed, A. ; Fujiyoshi, A. ; Evans, R. W. ; Hisamatsu, T. ; Ohkubo, T. ; Willcox, B. J. ; Kuller, L. H. ; Ueshima, H. ; Sekikawa, A. / Ectopic cardiovascular fat in middle-aged men : Effects of race/ethnicity, overall and central adiposity. The ERA JUMP study. In: International Journal of Obesity. 2015 ; Vol. 39, No. 3. pp. 488-494.
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abstract = "Background/objectives:Higher volumes of ectopic cardiovascular fat (ECF) are associated with greater risk of coronary heart disease (CHD). Identifying factors that are associated with ECF volumes may lead to new preventive efforts to reduce risk of CHD. Significant racial/ethnic differences exist for overall and central adiposity measures, which are known to be associated with ECF volumes. Whether racial/ethnic differences also exist for ECF volumes and their associations with these adiposity measures remain unclear.Subjects/methods:Body mass index (BMI), computerized tomography-measured ECF volumes (epicardial, pericardial and their summation) and visceral adipose tissue (VAT) were examined in a community-based sample of 1199 middle-aged men (24.2{\%} Caucasians, 7.0{\%} African-Americans, 23.6{\%} Japanese-Americans, 22.0{\%} Japanese, 23.2{\%} Koreans).Results:Significant racial/ethnic differences existed in ECF volumes and their relationships with BMI and VAT. ECF volumes were the highest among Japanese-Americans and the lowest among African-Americans. The associations of BMI and VAT with ECF differed by racial/ethnic groups. Compared with Caucasians, for each 1-unit increase in BMI, African-Americans had lower, whereas Koreans had higher increases in ECF volumes (P-values<0.05 for both). Meanwhile, compared with Caucasians, for each 1-unit increase in log-transformed VAT, African-Americans, Japanese-Americans and Japanese had similar increases, whereas Koreans had a lower increase in ECF volumes (P-value<0.05).Conclusions:Racial/ethnic groups differed in their propensity to accumulate ECF at increasing level of overall and central adiposity. Future studies should evaluate whether reducing central adiposity or overall weight will decrease ECF volumes more in certain racial/ethnic groups. Evaluating these questions might help in designing race-specific prevention strategy of CHD risk associated with higher ECF.",
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T2 - Effects of race/ethnicity, overall and central adiposity. The ERA JUMP study

AU - El Khoudary, S. R.

AU - Shin, Chol

AU - Masaki, K.

AU - Miura, K.

AU - Budoff, M.

AU - Edmundowicz, D.

AU - Kadowaki, S.

AU - Barinas-Mitchell, E.

AU - El-Saed, A.

AU - Fujiyoshi, A.

AU - Evans, R. W.

AU - Hisamatsu, T.

AU - Ohkubo, T.

AU - Willcox, B. J.

AU - Kuller, L. H.

AU - Ueshima, H.

AU - Sekikawa, A.

PY - 2015/3/12

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N2 - Background/objectives:Higher volumes of ectopic cardiovascular fat (ECF) are associated with greater risk of coronary heart disease (CHD). Identifying factors that are associated with ECF volumes may lead to new preventive efforts to reduce risk of CHD. Significant racial/ethnic differences exist for overall and central adiposity measures, which are known to be associated with ECF volumes. Whether racial/ethnic differences also exist for ECF volumes and their associations with these adiposity measures remain unclear.Subjects/methods:Body mass index (BMI), computerized tomography-measured ECF volumes (epicardial, pericardial and their summation) and visceral adipose tissue (VAT) were examined in a community-based sample of 1199 middle-aged men (24.2% Caucasians, 7.0% African-Americans, 23.6% Japanese-Americans, 22.0% Japanese, 23.2% Koreans).Results:Significant racial/ethnic differences existed in ECF volumes and their relationships with BMI and VAT. ECF volumes were the highest among Japanese-Americans and the lowest among African-Americans. The associations of BMI and VAT with ECF differed by racial/ethnic groups. Compared with Caucasians, for each 1-unit increase in BMI, African-Americans had lower, whereas Koreans had higher increases in ECF volumes (P-values<0.05 for both). Meanwhile, compared with Caucasians, for each 1-unit increase in log-transformed VAT, African-Americans, Japanese-Americans and Japanese had similar increases, whereas Koreans had a lower increase in ECF volumes (P-value<0.05).Conclusions:Racial/ethnic groups differed in their propensity to accumulate ECF at increasing level of overall and central adiposity. Future studies should evaluate whether reducing central adiposity or overall weight will decrease ECF volumes more in certain racial/ethnic groups. Evaluating these questions might help in designing race-specific prevention strategy of CHD risk associated with higher ECF.

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