Effect-directed analysis and mixture effects of AhR-active PAHs in crude oil and coastal sediments contaminated by the Hebei Spirit oil spill

Seongjin Hong, Sangwoo Lee, Kyungho Choi, Gi Beum Kim, Sung Yong Ha, Bong Oh Kwon, Jongseong Ryu, Un Hyuk Yim, Won Joon Shim, Jinho Jung, John P. Giesy, Jong Seong Khim

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Abstract

The major AhR-active PAHs were identified in crude oil and oil-contaminated sediments by use of effect-directed analysis. As part of the study, an enhanced potency balance analysis was conducted by establishing the novel relative potency values of (alkyl)-PAHs from the H4IIE-luc bioassay. Silica gel column fractionation of crude oil resulted in greater AhR-mediated potencies in fractions of aromatics (F2) and resins (F3), and such trend was also observed for field collected sediment samples. AhR-mediated potencies of six F2 sub-fractions from HPLC indicated that the majority of F2 responses were attributable to 3-4 ring aromatics. Target PAHs including C4-phenanthrene, C1-chrysene, and C3-chrysene in sediments explained ∼18% of the bioassay-derived TCDD-EQs, however, the unknown AhR agonists and potential mixture effects remain in question. Overall, the AhR-potency and antagonistic potential of residual oil in sediment tended to decrease over time, thus monitoring of weathering process would be key for the post management of oil-contaminated sites.

Original languageEnglish
Pages (from-to)110-118
Number of pages9
JournalEnvironmental Pollution
Volume199
DOIs
Publication statusPublished - 2015

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Keywords

  • Effect-directed analysis
  • H4IIE-luc bioassay
  • Oil weathering
  • Polycyclic aromatic hydrocarbons
  • Sediments
  • Yellow Sea

ASJC Scopus subject areas

  • Pollution
  • Health, Toxicology and Mutagenesis
  • Toxicology

Cite this

Hong, S., Lee, S., Choi, K., Kim, G. B., Ha, S. Y., Kwon, B. O., Ryu, J., Yim, U. H., Shim, W. J., Jung, J., Giesy, J. P., & Khim, J. S. (2015). Effect-directed analysis and mixture effects of AhR-active PAHs in crude oil and coastal sediments contaminated by the Hebei Spirit oil spill. Environmental Pollution, 199, 110-118. https://doi.org/10.1016/j.envpol.2015.01.009