Effect of anthocyanins on expression of matrix metalloproteinase-2 in naproxen-induced gastric ulcers

Sun Joong Kim, Young Sam Park, Hyun Dong Paik, Hyo Ihl Chang

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Non-steroidal anti-inflammatory drugs cause gastric ulceration through a number of mechanisms including inhibition of PG synthesis, generation of reactive oxygen species (ROS) and induction of apoptosis. Recently, matrix metalloproteinases (MMP) have been suggested to play a crucial role in these mechanisms. The present study investigated the protective effect of anthocyanins isolated from black rice bran (Heugjinjubyeo) against naproxen-induced gastric mucosal injury in rats. The oral administration of anthocyanins (5, 25 or 50mg/kg body weight) showed significant protection against naproxen (80mg/kg body weight)-induced gastric ulcer and inhibited lipid peroxidation in the gastric mucosa. In addition, pretreatment with anthocyanins resulted in a significant increase in the activities of radical-scavenging enzymes such as superoxide dismutase, catalase and glutathione peroxidase. Also biochemical and zymographic analyses suggested that the administration of anthocyanins gives a significant protection against naproxen-induced gastric antral ulcer through scavenging ROS and regulation of matrix metalloproteinase-2 (MMP-2) activity. The results of intracellular radical activation show that anthocyanins suppress the generation of intracellular ROS and attenuate the suppression of MMP-2 activity by naproxen. These results suggest that anthocyanins extracted from black rice may offer potential remedy of gastric antral ulceration.

Original languageEnglish
Pages (from-to)1792-1801
Number of pages10
JournalBritish Journal of Nutrition
Volume106
Issue number12
DOIs
Publication statusPublished - 2011 Dec 28

Keywords

  • Anthocyanins
  • Gastric ulcers
  • Matrix metalloproteinase
  • Reactive oxygen species

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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