Effect of bacteriocin produced by Lactococcus sp. HY 449 on skin-inflammatory bacteria

Sejong Oh, Sae Hun Kim, Yong Ko, Jae Hun Sim, Kwang Soo Kim, Seung Hwa Lee, Sungsu Park, Young Jun Kim

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

This study was carried out to evaluate the effect of bacteriocin produced by Lactococcus sp. HY 449 against skin-inflammatory bacteria such as Staphylococcus epidermidis ATCC 12228, Staphylococcus aureus ATCC 65389, Streptococcus pyogenes ATCC 21059, and Propionibacterium acnes ATCC 6919. The spot-on-the-lawn method was used to determine the antimicrobial activity of bacteriocin against indicator strains on the human skin. The bacteriocin produced by Lactococcus sp. HY 449 inhibited the growth of S. epidermidis ATCC 12228, S. aureus ATCC 65389, Strep. pyogenes ATCC 21059, and P. acnes ATCC 6919. The treatment of crude bacteriocin caused a rapid inactivation of P. acnes ATCC 6919. The LC50 of bacteriocin on human fibroblast was ca. 50 mg/ml at which the inhibition of cell proliferation was not observed. Neither any irritations nor allergic reactions by the bacteriocin were evident in a human patch test. The bacteriocin produced by Lactococcus sp. HY 449 may be a useful antimicrobial substance to control the growth of P. acnes and to prevent skin inflammation and acne.

Original languageEnglish
Pages (from-to)1184-1190
Number of pages7
JournalFood and Chemical Toxicology
Volume44
Issue number8
DOIs
Publication statusPublished - 2006 Aug 1

Fingerprint

Lactococcus
Bacteriocins
bacteriocins
skin (animal)
Propionibacterium acnes
Bacteria
Skin
bacteria
Staphylococcus epidermidis
Staphylococcus aureus
anti-infective agents
patch test
acne
Streptococcus pyogenes
Patch Tests
Acne Vulgaris
Cell proliferation
Fibroblasts
Growth
lethal concentration 50

Keywords

  • Bacteriocin
  • Cosmetics
  • Inflammation
  • Lactococcus
  • Skin

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Effect of bacteriocin produced by Lactococcus sp. HY 449 on skin-inflammatory bacteria. / Oh, Sejong; Kim, Sae Hun; Ko, Yong; Sim, Jae Hun; Kim, Kwang Soo; Lee, Seung Hwa; Park, Sungsu; Kim, Young Jun.

In: Food and Chemical Toxicology, Vol. 44, No. 8, 01.08.2006, p. 1184-1190.

Research output: Contribution to journalArticle

Oh, Sejong ; Kim, Sae Hun ; Ko, Yong ; Sim, Jae Hun ; Kim, Kwang Soo ; Lee, Seung Hwa ; Park, Sungsu ; Kim, Young Jun. / Effect of bacteriocin produced by Lactococcus sp. HY 449 on skin-inflammatory bacteria. In: Food and Chemical Toxicology. 2006 ; Vol. 44, No. 8. pp. 1184-1190.
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