Effect of caffeic acid on apical transporters' dysfunction of renal proximal tubule cells under oxidative stress in vitro

Jae Han Ho, Hyun Park Soo, Moo Park Kwon, Cheol Yoon Byung, Tae Sung Kim, Hern Lee Jang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The protective effect of caffeic acid (CA) against oxidative stress-induced inhibition of proximal tubule apical transporter was investigated. In the present study, 10 -4 M H 2O 2 did not affect cell viability regardless of incubation time, However, it decreased apical transporters' activity such as Na +/glucose cotransporter, Na +/Pi cotransporter, and Na +/H + antiporter in the proximal tubule cells. CA (>10 -6 M) prevented H 2O 2-induced inhibition of apical transporters. Thus, we investigated its action mechanism, CA also prevented H 2O 2-induced lipid peroxides formation, arachidonic acid (AA) release, and Ca 2+ uptake. In conclusion, CA, in part, prevented H 2O 2-induced inhibition of apical transporter activity via decrease of AA release and Ca 2+ uptake in primary cultured renal proximal tubule cells.

Original languageEnglish
Pages (from-to)483-486
Number of pages4
JournalPlanta Medica
Volume68
Issue number6
DOIs
Publication statusPublished - 2002 Jul 25
Externally publishedYes

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Keywords

  • Apical transporter
  • Arachidonic acid
  • Ca
  • Caffeic acid
  • H O
  • Kidney

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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