Effect of caffeic acid on apical transporters' dysfunction of renal proximal tubule cells under oxidative stress in vitro

Jae Han Ho, Hyun Park Soo, Moo Park Kwon, Cheol Yoon Byung, Sung Kim Tae, Hern Lee Jang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The protective effect of caffeic acid (CA) against oxidative stress-induced inhibition of proximal tubule apical transporter was investigated. In the present study, 10-4 M H2O2 did not affect cell viability regardless of incubation time, However, it decreased apical transporters' activity such as Na+/glucose cotransporter, Na+/Pi cotransporter, and Na+/H+ antiporter in the proximal tubule cells. CA (>10-6 M) prevented H2O2-induced inhibition of apical transporters. Thus, we investigated its action mechanism, CA also prevented H2O2-induced lipid peroxides formation, arachidonic acid (AA) release, and Ca2+ uptake. In conclusion, CA, in part, prevented H2O2-induced inhibition of apical transporter activity via decrease of AA release and Ca2+ uptake in primary cultured renal proximal tubule cells.

Original languageEnglish
Pages (from-to)483-486
Number of pages4
JournalPlanta Medica
Volume68
Issue number6
DOIs
Publication statusPublished - 2002
Externally publishedYes

Keywords

  • Apical transporter
  • Arachidonic acid
  • Ca
  • Caffeic acid
  • HO
  • Kidney

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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