Effect of CaF2 on densification and properties of hydroxyapatite-zirconia composites for biomedical applications

Hae Won Kim, Yoon Jung Noh, Young-Hag Koh, Hyoun Ee Kim, Hyun Man Kim

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Hydroxyapatite (HA) composites with zirconia (ZrO2) up to 40vol% were fabricated with the addition of CaF2. The sinterability of the composites was found to be enhanced markedly by the addition of small amounts of CaF2 (<5vol%). Decomposition of HA to β-TCP was suppressed due to the substitution of F- for OH-, consequently forming fluor-hydroxyapatite (FHA) solid solution. This suppression of decomposition allowed the production of a fully dense body, which retained both high flexural strength and fracture toughness. The osteoblast-like cell (MG63) response to these F- ion-containing composites displayed comparable cell viability to pure-HA by in vitro proliferation test.

Original languageEnglish
Pages (from-to)4113-4121
Number of pages9
JournalBiomaterials
Volume23
Issue number20
DOIs
Publication statusPublished - 2002 Jul 24
Externally publishedYes

Keywords

  • CaF
  • Cell viability
  • Densification
  • HA
  • Strength
  • Substitution
  • Toughness
  • ZrO

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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