Effect of calcium dobesilate in preventing contrast-induced nephropathy in patients with diabetes and chronic kidney disease

Hao Zhang, Shao Hua Guo, Zheng Kai Xue, Ya Ru Zhang, Jia Rui Wang, Jing Jin Che, Tong Liu, Hua Yue Tao, Guang Ping Li, Seung Woon Rha, Swapnil Zaman Ashraful-Haque, Kang Yin Chen

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVES: This study assessed the protective effect of calcium dobesilate against contrast-induced nephropathy (CIN) after coronary angiography (CAG) or percutaneous coronary intervention (PCI) in patients with diabetes and chronic kidney disease (CKD). METHODS: A total of 130 patients with diabetes and CKD estimated glomerular filtration rate: 30–90 mL/min/ 1.73m2 were enrolled and included in the analysis. They were divided into experimental (n=65) and control groups (n=65). Patients in the experimental group were administered oral calcium dobesilate (500 mg) three times daily for 2 days before and 3 days after the procedure. The serum creatinine (SCr), cystatin C (Cys C), and neutrophil gelatinase-associated lipocalin (NGAL) levels were measured before and after the procedure. RESULTS: The mean SCr level at 24h after the procedure was found to be significantly lower in the experimental group than in the control group (79.1±19.6 mmol/L vs. 87.0±19.3 mmol/L, p=0.023). However, the Cys C and NGAL levels were not significantly different between the two groups at all measurement time points (all p>0.05). The incidence of CIN defined by the SCr level was significantly lower in the experimental group than in the control group (3 [4.6%] vs. 13 [20.0%], p=0.017). However, the incidence of CIN defined by the Cys C level was not statistically different between the two groups (7 [10.8%] vs. 7 [10.8%], p=1.000). CONCLUSIONS: This study revealed that calcium dobesilate has no preventive effect against CIN in patients with diabetes and CKD.

Original languageEnglish
Article numbere2942
JournalClinics
Volume76
DOIs
Publication statusPublished - 2021

Keywords

  • Calcium dobesilate
  • Chronic Renal Insufficiency
  • Contrast-Induced Acute Kidney Injury
  • Coronary Angiography
  • Diabetes Mellitus

ASJC Scopus subject areas

  • Medicine(all)

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