Effect of CYP3A5*3 genotype on serum carbamazepine concentrations at steady-state in Korean epileptic patients

P. W. Park, Y. H. Seo, J. Y. Ahn, K. A. Kim, J. Y. Park

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Background and Objective: Carbamazepine (CBZ) is metabolized mainly by the CYP3A family of enzymes, which includes CYP3A4 and CYP3A5. Several studies have suggested that the CYP3A5*3 genotype influences the pharmacokinetics of CYP3A substrates. The present study aimed to assess the effect of the CYP3A5*3 genotype on serum concentration of CBZ at the steady-state in Korean epileptic patients. Method: The serum concentrations of CBZ in 35 Korean epileptic patients were measured and their CYP3A5 genotype was determined. Fourteen patients were CYP3A5 expressors (two for CYP3A5*1/*1 and 12 for CYP3A5*1/*3) and 21 patients were CYP3A5 non-expressors (CYP3A5*3/*3). Dose-normalized concentrations (mean ± SD) of CBZ were 9·9 ± 3·4 ng/mL/mg for CYP3A5 expressors and 13·1 ± 4·5 ng/mL/mg for CYP3A5 non-expressors (P = 0·032). The oral clearance of CBZ was significantly higher in CYP3A5 non-expressors than that of CYP3A5 expressors (0·056 ±0·017 L/h/kg vs. 0·040 ± 0·014 L/h/kg, P = 0·004). The CYP3A5 genotype affected the CBZ concentrations in Korean epileptic patients and is a factor that may contribute to inter-individual variability in CBZ disposition in epileptic patients.

Original languageEnglish
Pages (from-to)569-574
Number of pages6
JournalJournal of Clinical Pharmacy and Therapeutics
Volume34
Issue number5
DOIs
Publication statusPublished - 2009 Oct

Keywords

  • CYP3A53
  • Carbamazepine
  • Cytochrome P450 3A5 (CYP3A5)
  • Pharmacogenetics
  • Therapeutic drug monitoring

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Effect of CYP3A5*3 genotype on serum carbamazepine concentrations at steady-state in Korean epileptic patients'. Together they form a unique fingerprint.

  • Cite this