Effect of desipramine and citalopram treatment on forced swimming test-induced changes in Cocaine- and Amphetamine-Regulated Transcript (CART) immunoreactivity in mice

Sung Chung, Hee Jeong Kim, Hyun Ju Kim, Sun Hye Choi, Jin Wook Kim, Jeong Min Kim, Kyung-Ho Shin

Research output: Contribution to journalArticle

Abstract

Recent study demonstrates antidepressant-like effect of cocaine- and amphetamine-regulated transcript (CART) in the forced swimming test (FST), but less is known about whether antidepressant treatments alter levels of CART immunoreactivity (CART-IR) in the FST. To explore this possibility, we assessed the treatment effects of desipramine and citalopram, which inhibit the reuptake of norepinephrine and serotonin into the presynaptic terminals, respectively, on changes in levels of CART-IR before and after the test swim in mouse brain. Levels of CART-IR in the nucleus accumbens shell (AcbSh), dorsal bed nucleus of the stria terminalis (dBNST), and hypothalamic paraventricular nucleus (PVN) were significantly increased before the test swim by desipramine and citalopram treatments. This increase in CART-IR in the AcbSh, dBNST, and PVN before the test swim remained elevated by desipramine treatment after the test swim, but this increase in these brain areas returned to near control levels after test swim by citalopram treatment. Citalopram, but not desipramine, treatment increased levels of CART-IR in the central nucleus of the amygdala (CeA) and the locus ceruleus (LC) before the test swim, and this increase was returned to control levels after the test swim in the CeA, but not in the LC. These results suggest common and distinct regulation of CART by desipramine and citalopram treatments in the FST and raise the possibility that CART in the AcbSh, dBNST, and CeA may be involved in anti-depressant-like effect in the FST.

Original languageEnglish
Pages (from-to)961-972
Number of pages12
JournalNeurochemical Research
Volume39
Issue number5
DOIs
Publication statusPublished - 2014 Jan 1

Keywords

  • Amygdala
  • Antidepressive agents
  • Bed nucleus of the stria terminalis
  • Cocaine- and amphetamine-regulated transcript protein
  • Nucleus accumbens
  • Swimming

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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