Effect of early statin treatment in patients with cardiogenic shock complicating acute myocardial infarction

Doo Sun Sim, Myung Ho Jeong, Kyung Hoon Cho, Youngkeun Ahn, Young Jo Kim, Shung Chull Chae, Taek Jong Hong, In Whan Seong, Jei Keon Chae, Chong Jin Kim, Myeong Chan Cho, Seung-Woon Rha, Jang Ho Bae, Ki Bae Seung, Seung Jung Park, Jong Hyun Kim, Seung Ho Hur, Jae Young Rhew, Doo Il Kim, In Ho ChaeJung Han Yoon, Bon Kwon Koo, Byung Ok Kim, Myoung Yong Lee, Kee Sik Kim, Jin Yong Hwang, Seok Kyu Oh, Nae Hee Lee, Kyoung Tae Jeong, Seung Jea Tahk, Keum Soo Park, Kyoo Rok Han, Tae Hoon Ahn, Moo Hyun Kim, Wook Sung Chung, Ju Young Yang, Chong Yun Rhim, Hyeon Cheol Gwon, Seong Wook Park, Young Youp Koh, Seung Jae Joo, Soo Joong Kim, Dong Kyu Jin, Jin Man Cho, Yang Soo Jang, Jeong Gwan Cho

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background and Objectives: The benefit of early statin treatment following acute myocardial infarction (MI) complicated with cardiogenic shock (CS) has not been well studied. We sought to assess the effect of early statin therapy in patients with CS complicating acute MI. Subjects and Methods: We studied 553 statin-naïve patients with acute MI and CS (Killip class IV) who underwent revascularization therapy between November 2005 and January 2008 at 51 hospitals in the Korea Acute Myocardial Infarction Registry. Patients were divided into 2 groups: those who received statins during hospitalization (n=280) and those who did not (n=273). The influence of statin treatment on a 12-month clinical outcome was examined using a matched-pairs analysis (n=200 in each group) based on the propensity for receiving statin therapy during hospitalization. Results: Before adjustment, patients receiving statin, compared to those not receiving statin, had a more favorable clinical profile, were less likely to suffer procedural complications, and more likely to receive adequate medical therapy. Patients receiving statin had lower unadjusted in-hospital mortality and composite rate of mortality, Ml, and repeat revascularization at 12 months, which remained significantly lower after adjustment for patient risk, procedural characteristics, and treatment propensity. Conclusion: In CS patients with acute MI undergoing revascularization therapy, early statin treatment initiated during hospitalization was associated with lower rates of in-hospital death and 12-month adverse cardiac events.

Original languageEnglish
Pages (from-to)100-109
Number of pages10
JournalKorean Circulation Journal
Volume43
Issue number2
DOIs
Publication statusPublished - 2013 Feb 1

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cardiogenic Shock
Myocardial Infarction
Therapeutics
Hospitalization
Risk Adjustment
Matched-Pair Analysis
Mortality
Korea
Secondary Prevention
Hospital Mortality
Registries

Keywords

  • Angioplasty
  • Myocardial infarction
  • Shock

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

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Effect of early statin treatment in patients with cardiogenic shock complicating acute myocardial infarction. / Sim, Doo Sun; Jeong, Myung Ho; Cho, Kyung Hoon; Ahn, Youngkeun; Kim, Young Jo; Chae, Shung Chull; Hong, Taek Jong; Seong, In Whan; Chae, Jei Keon; Kim, Chong Jin; Cho, Myeong Chan; Rha, Seung-Woon; Bae, Jang Ho; Seung, Ki Bae; Park, Seung Jung; Kim, Jong Hyun; Hur, Seung Ho; Rhew, Jae Young; Kim, Doo Il; Chae, In Ho; Yoon, Jung Han; Koo, Bon Kwon; Kim, Byung Ok; Lee, Myoung Yong; Kim, Kee Sik; Hwang, Jin Yong; Oh, Seok Kyu; Lee, Nae Hee; Jeong, Kyoung Tae; Tahk, Seung Jea; Park, Keum Soo; Han, Kyoo Rok; Ahn, Tae Hoon; Kim, Moo Hyun; Chung, Wook Sung; Yang, Ju Young; Rhim, Chong Yun; Gwon, Hyeon Cheol; Park, Seong Wook; Koh, Young Youp; Joo, Seung Jae; Kim, Soo Joong; Jin, Dong Kyu; Cho, Jin Man; Jang, Yang Soo; Cho, Jeong Gwan.

In: Korean Circulation Journal, Vol. 43, No. 2, 01.02.2013, p. 100-109.

Research output: Contribution to journalArticle

Sim, DS, Jeong, MH, Cho, KH, Ahn, Y, Kim, YJ, Chae, SC, Hong, TJ, Seong, IW, Chae, JK, Kim, CJ, Cho, MC, Rha, S-W, Bae, JH, Seung, KB, Park, SJ, Kim, JH, Hur, SH, Rhew, JY, Kim, DI, Chae, IH, Yoon, JH, Koo, BK, Kim, BO, Lee, MY, Kim, KS, Hwang, JY, Oh, SK, Lee, NH, Jeong, KT, Tahk, SJ, Park, KS, Han, KR, Ahn, TH, Kim, MH, Chung, WS, Yang, JY, Rhim, CY, Gwon, HC, Park, SW, Koh, YY, Joo, SJ, Kim, SJ, Jin, DK, Cho, JM, Jang, YS & Cho, JG 2013, 'Effect of early statin treatment in patients with cardiogenic shock complicating acute myocardial infarction', Korean Circulation Journal, vol. 43, no. 2, pp. 100-109. https://doi.org/10.4070/kcj.2013.43.2.100
Sim, Doo Sun ; Jeong, Myung Ho ; Cho, Kyung Hoon ; Ahn, Youngkeun ; Kim, Young Jo ; Chae, Shung Chull ; Hong, Taek Jong ; Seong, In Whan ; Chae, Jei Keon ; Kim, Chong Jin ; Cho, Myeong Chan ; Rha, Seung-Woon ; Bae, Jang Ho ; Seung, Ki Bae ; Park, Seung Jung ; Kim, Jong Hyun ; Hur, Seung Ho ; Rhew, Jae Young ; Kim, Doo Il ; Chae, In Ho ; Yoon, Jung Han ; Koo, Bon Kwon ; Kim, Byung Ok ; Lee, Myoung Yong ; Kim, Kee Sik ; Hwang, Jin Yong ; Oh, Seok Kyu ; Lee, Nae Hee ; Jeong, Kyoung Tae ; Tahk, Seung Jea ; Park, Keum Soo ; Han, Kyoo Rok ; Ahn, Tae Hoon ; Kim, Moo Hyun ; Chung, Wook Sung ; Yang, Ju Young ; Rhim, Chong Yun ; Gwon, Hyeon Cheol ; Park, Seong Wook ; Koh, Young Youp ; Joo, Seung Jae ; Kim, Soo Joong ; Jin, Dong Kyu ; Cho, Jin Man ; Jang, Yang Soo ; Cho, Jeong Gwan. / Effect of early statin treatment in patients with cardiogenic shock complicating acute myocardial infarction. In: Korean Circulation Journal. 2013 ; Vol. 43, No. 2. pp. 100-109.
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abstract = "Background and Objectives: The benefit of early statin treatment following acute myocardial infarction (MI) complicated with cardiogenic shock (CS) has not been well studied. We sought to assess the effect of early statin therapy in patients with CS complicating acute MI. Subjects and Methods: We studied 553 statin-na{\"i}ve patients with acute MI and CS (Killip class IV) who underwent revascularization therapy between November 2005 and January 2008 at 51 hospitals in the Korea Acute Myocardial Infarction Registry. Patients were divided into 2 groups: those who received statins during hospitalization (n=280) and those who did not (n=273). The influence of statin treatment on a 12-month clinical outcome was examined using a matched-pairs analysis (n=200 in each group) based on the propensity for receiving statin therapy during hospitalization. Results: Before adjustment, patients receiving statin, compared to those not receiving statin, had a more favorable clinical profile, were less likely to suffer procedural complications, and more likely to receive adequate medical therapy. Patients receiving statin had lower unadjusted in-hospital mortality and composite rate of mortality, Ml, and repeat revascularization at 12 months, which remained significantly lower after adjustment for patient risk, procedural characteristics, and treatment propensity. Conclusion: In CS patients with acute MI undergoing revascularization therapy, early statin treatment initiated during hospitalization was associated with lower rates of in-hospital death and 12-month adverse cardiac events.",
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author = "Sim, {Doo Sun} and Jeong, {Myung Ho} and Cho, {Kyung Hoon} and Youngkeun Ahn and Kim, {Young Jo} and Chae, {Shung Chull} and Hong, {Taek Jong} and Seong, {In Whan} and Chae, {Jei Keon} and Kim, {Chong Jin} and Cho, {Myeong Chan} and Seung-Woon Rha and Bae, {Jang Ho} and Seung, {Ki Bae} and Park, {Seung Jung} and Kim, {Jong Hyun} and Hur, {Seung Ho} and Rhew, {Jae Young} and Kim, {Doo Il} and Chae, {In Ho} and Yoon, {Jung Han} and Koo, {Bon Kwon} and Kim, {Byung Ok} and Lee, {Myoung Yong} and Kim, {Kee Sik} and Hwang, {Jin Yong} and Oh, {Seok Kyu} and Lee, {Nae Hee} and Jeong, {Kyoung Tae} and Tahk, {Seung Jea} and Park, {Keum Soo} and Han, {Kyoo Rok} and Ahn, {Tae Hoon} and Kim, {Moo Hyun} and Chung, {Wook Sung} and Yang, {Ju Young} and Rhim, {Chong Yun} and Gwon, {Hyeon Cheol} and Park, {Seong Wook} and Koh, {Young Youp} and Joo, {Seung Jae} and Kim, {Soo Joong} and Jin, {Dong Kyu} and Cho, {Jin Man} and Jang, {Yang Soo} and Cho, {Jeong Gwan}",
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AU - Sim, Doo Sun

AU - Jeong, Myung Ho

AU - Cho, Kyung Hoon

AU - Ahn, Youngkeun

AU - Kim, Young Jo

AU - Chae, Shung Chull

AU - Hong, Taek Jong

AU - Seong, In Whan

AU - Chae, Jei Keon

AU - Kim, Chong Jin

AU - Cho, Myeong Chan

AU - Rha, Seung-Woon

AU - Bae, Jang Ho

AU - Seung, Ki Bae

AU - Park, Seung Jung

AU - Kim, Jong Hyun

AU - Hur, Seung Ho

AU - Rhew, Jae Young

AU - Kim, Doo Il

AU - Chae, In Ho

AU - Yoon, Jung Han

AU - Koo, Bon Kwon

AU - Kim, Byung Ok

AU - Lee, Myoung Yong

AU - Kim, Kee Sik

AU - Hwang, Jin Yong

AU - Oh, Seok Kyu

AU - Lee, Nae Hee

AU - Jeong, Kyoung Tae

AU - Tahk, Seung Jea

AU - Park, Keum Soo

AU - Han, Kyoo Rok

AU - Ahn, Tae Hoon

AU - Kim, Moo Hyun

AU - Chung, Wook Sung

AU - Yang, Ju Young

AU - Rhim, Chong Yun

AU - Gwon, Hyeon Cheol

AU - Park, Seong Wook

AU - Koh, Young Youp

AU - Joo, Seung Jae

AU - Kim, Soo Joong

AU - Jin, Dong Kyu

AU - Cho, Jin Man

AU - Jang, Yang Soo

AU - Cho, Jeong Gwan

PY - 2013/2/1

Y1 - 2013/2/1

N2 - Background and Objectives: The benefit of early statin treatment following acute myocardial infarction (MI) complicated with cardiogenic shock (CS) has not been well studied. We sought to assess the effect of early statin therapy in patients with CS complicating acute MI. Subjects and Methods: We studied 553 statin-naïve patients with acute MI and CS (Killip class IV) who underwent revascularization therapy between November 2005 and January 2008 at 51 hospitals in the Korea Acute Myocardial Infarction Registry. Patients were divided into 2 groups: those who received statins during hospitalization (n=280) and those who did not (n=273). The influence of statin treatment on a 12-month clinical outcome was examined using a matched-pairs analysis (n=200 in each group) based on the propensity for receiving statin therapy during hospitalization. Results: Before adjustment, patients receiving statin, compared to those not receiving statin, had a more favorable clinical profile, were less likely to suffer procedural complications, and more likely to receive adequate medical therapy. Patients receiving statin had lower unadjusted in-hospital mortality and composite rate of mortality, Ml, and repeat revascularization at 12 months, which remained significantly lower after adjustment for patient risk, procedural characteristics, and treatment propensity. Conclusion: In CS patients with acute MI undergoing revascularization therapy, early statin treatment initiated during hospitalization was associated with lower rates of in-hospital death and 12-month adverse cardiac events.

AB - Background and Objectives: The benefit of early statin treatment following acute myocardial infarction (MI) complicated with cardiogenic shock (CS) has not been well studied. We sought to assess the effect of early statin therapy in patients with CS complicating acute MI. Subjects and Methods: We studied 553 statin-naïve patients with acute MI and CS (Killip class IV) who underwent revascularization therapy between November 2005 and January 2008 at 51 hospitals in the Korea Acute Myocardial Infarction Registry. Patients were divided into 2 groups: those who received statins during hospitalization (n=280) and those who did not (n=273). The influence of statin treatment on a 12-month clinical outcome was examined using a matched-pairs analysis (n=200 in each group) based on the propensity for receiving statin therapy during hospitalization. Results: Before adjustment, patients receiving statin, compared to those not receiving statin, had a more favorable clinical profile, were less likely to suffer procedural complications, and more likely to receive adequate medical therapy. Patients receiving statin had lower unadjusted in-hospital mortality and composite rate of mortality, Ml, and repeat revascularization at 12 months, which remained significantly lower after adjustment for patient risk, procedural characteristics, and treatment propensity. Conclusion: In CS patients with acute MI undergoing revascularization therapy, early statin treatment initiated during hospitalization was associated with lower rates of in-hospital death and 12-month adverse cardiac events.

KW - Angioplasty

KW - Myocardial infarction

KW - Shock

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