Effect of exercise training on A-FABP, lipocalin-2 and RBP4 levels in obese women

Kyung Mook Choi, T. N. Kim, Hye-Jin Yoo, K. W. Lee, Geum-Joon Cho, T. G. Hwang, Sei-Hyun Baik, D. S. Choi, Seon Mee Kim

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Objective Lipocalin family proteins, including adipocyte fatty acid-binding protein (A-FABP), lipocalin-2 and retinol-binding protein 4 (RBP4), have recently been identified as novel adipokines associated with obesity, type 2 diabetes and the metabolic syndrome. We have evaluated the effect of exercise training on lipocalin family proteins and inflammatory markers. Study subjects Thirty obese Korean women and 15 age-matched nonobese control subjects were studied. Design Concentrations of the lipocalin family proteins were compared between obese and nonobese women and were evaluated before and 3 months after an exercise programme consisting of aerobic exercise (45 min/session, 300 kcal/day) and muscle strength training (20 min/session, 100 kcal/day) five times a week. Results Obese women exhibited higher A-FABP levels compared to nonobese women (21·4 ± 6·4 μg/l vs. 13·6 ± 4·4 μg/l, P < 0·001). However, neither lipocalin-2 nor RBP4 levels were significantly different between the two groups, although the difference in lipocalin-2 was marginally significant (P = 0·054). Circulating A-FABP levels were significantly associated with body mass index (BMI), waist circumference, triglyceride, alanine aminotransferase (ALT), lipocalin-2 and high-sensitivity C-reactive protein (hsCRP) levels. After 3 months of the exercise training programme, serum A-FABP levels decreased significantly from 21·4 ± 6·4 μg/l to 19·3 ± 6·8 μg/l (P = 0·038), along with a reduction in weight, BMI, waist circumference, fasting glucose and total cholesterol levels. There was no significant change in the lipocalin-2 and RBP4 levels, although IL-6 levels increased after the exercise programme. Conclusion Exercise training with weight loss induced a significant reduction in circulating A-FABP levels in obese Korean women.

Original languageEnglish
Pages (from-to)569-574
Number of pages6
JournalClinical Endocrinology
Volume70
Issue number4
DOIs
Publication statusPublished - 2009 Apr 1

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Retinol-Binding Proteins
Fatty Acid-Binding Proteins
Adipocytes
Exercise
Lipocalins
Waist Circumference
Weight Loss
Body Mass Index
Proteins
Adipokines
Resistance Training
Muscle Strength
Alanine Transaminase
C-Reactive Protein
Type 2 Diabetes Mellitus
Lipocalin-2
Interleukin-6
Fasting
Triglycerides
Obesity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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Effect of exercise training on A-FABP, lipocalin-2 and RBP4 levels in obese women. / Choi, Kyung Mook; Kim, T. N.; Yoo, Hye-Jin; Lee, K. W.; Cho, Geum-Joon; Hwang, T. G.; Baik, Sei-Hyun; Choi, D. S.; Kim, Seon Mee.

In: Clinical Endocrinology, Vol. 70, No. 4, 01.04.2009, p. 569-574.

Research output: Contribution to journalArticle

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abstract = "Objective Lipocalin family proteins, including adipocyte fatty acid-binding protein (A-FABP), lipocalin-2 and retinol-binding protein 4 (RBP4), have recently been identified as novel adipokines associated with obesity, type 2 diabetes and the metabolic syndrome. We have evaluated the effect of exercise training on lipocalin family proteins and inflammatory markers. Study subjects Thirty obese Korean women and 15 age-matched nonobese control subjects were studied. Design Concentrations of the lipocalin family proteins were compared between obese and nonobese women and were evaluated before and 3 months after an exercise programme consisting of aerobic exercise (45 min/session, 300 kcal/day) and muscle strength training (20 min/session, 100 kcal/day) five times a week. Results Obese women exhibited higher A-FABP levels compared to nonobese women (21·4 ± 6·4 μg/l vs. 13·6 ± 4·4 μg/l, P < 0·001). However, neither lipocalin-2 nor RBP4 levels were significantly different between the two groups, although the difference in lipocalin-2 was marginally significant (P = 0·054). Circulating A-FABP levels were significantly associated with body mass index (BMI), waist circumference, triglyceride, alanine aminotransferase (ALT), lipocalin-2 and high-sensitivity C-reactive protein (hsCRP) levels. After 3 months of the exercise training programme, serum A-FABP levels decreased significantly from 21·4 ± 6·4 μg/l to 19·3 ± 6·8 μg/l (P = 0·038), along with a reduction in weight, BMI, waist circumference, fasting glucose and total cholesterol levels. There was no significant change in the lipocalin-2 and RBP4 levels, although IL-6 levels increased after the exercise programme. Conclusion Exercise training with weight loss induced a significant reduction in circulating A-FABP levels in obese Korean women.",
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T1 - Effect of exercise training on A-FABP, lipocalin-2 and RBP4 levels in obese women

AU - Choi, Kyung Mook

AU - Kim, T. N.

AU - Yoo, Hye-Jin

AU - Lee, K. W.

AU - Cho, Geum-Joon

AU - Hwang, T. G.

AU - Baik, Sei-Hyun

AU - Choi, D. S.

AU - Kim, Seon Mee

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N2 - Objective Lipocalin family proteins, including adipocyte fatty acid-binding protein (A-FABP), lipocalin-2 and retinol-binding protein 4 (RBP4), have recently been identified as novel adipokines associated with obesity, type 2 diabetes and the metabolic syndrome. We have evaluated the effect of exercise training on lipocalin family proteins and inflammatory markers. Study subjects Thirty obese Korean women and 15 age-matched nonobese control subjects were studied. Design Concentrations of the lipocalin family proteins were compared between obese and nonobese women and were evaluated before and 3 months after an exercise programme consisting of aerobic exercise (45 min/session, 300 kcal/day) and muscle strength training (20 min/session, 100 kcal/day) five times a week. Results Obese women exhibited higher A-FABP levels compared to nonobese women (21·4 ± 6·4 μg/l vs. 13·6 ± 4·4 μg/l, P < 0·001). However, neither lipocalin-2 nor RBP4 levels were significantly different between the two groups, although the difference in lipocalin-2 was marginally significant (P = 0·054). Circulating A-FABP levels were significantly associated with body mass index (BMI), waist circumference, triglyceride, alanine aminotransferase (ALT), lipocalin-2 and high-sensitivity C-reactive protein (hsCRP) levels. After 3 months of the exercise training programme, serum A-FABP levels decreased significantly from 21·4 ± 6·4 μg/l to 19·3 ± 6·8 μg/l (P = 0·038), along with a reduction in weight, BMI, waist circumference, fasting glucose and total cholesterol levels. There was no significant change in the lipocalin-2 and RBP4 levels, although IL-6 levels increased after the exercise programme. Conclusion Exercise training with weight loss induced a significant reduction in circulating A-FABP levels in obese Korean women.

AB - Objective Lipocalin family proteins, including adipocyte fatty acid-binding protein (A-FABP), lipocalin-2 and retinol-binding protein 4 (RBP4), have recently been identified as novel adipokines associated with obesity, type 2 diabetes and the metabolic syndrome. We have evaluated the effect of exercise training on lipocalin family proteins and inflammatory markers. Study subjects Thirty obese Korean women and 15 age-matched nonobese control subjects were studied. Design Concentrations of the lipocalin family proteins were compared between obese and nonobese women and were evaluated before and 3 months after an exercise programme consisting of aerobic exercise (45 min/session, 300 kcal/day) and muscle strength training (20 min/session, 100 kcal/day) five times a week. Results Obese women exhibited higher A-FABP levels compared to nonobese women (21·4 ± 6·4 μg/l vs. 13·6 ± 4·4 μg/l, P < 0·001). However, neither lipocalin-2 nor RBP4 levels were significantly different between the two groups, although the difference in lipocalin-2 was marginally significant (P = 0·054). Circulating A-FABP levels were significantly associated with body mass index (BMI), waist circumference, triglyceride, alanine aminotransferase (ALT), lipocalin-2 and high-sensitivity C-reactive protein (hsCRP) levels. After 3 months of the exercise training programme, serum A-FABP levels decreased significantly from 21·4 ± 6·4 μg/l to 19·3 ± 6·8 μg/l (P = 0·038), along with a reduction in weight, BMI, waist circumference, fasting glucose and total cholesterol levels. There was no significant change in the lipocalin-2 and RBP4 levels, although IL-6 levels increased after the exercise programme. Conclusion Exercise training with weight loss induced a significant reduction in circulating A-FABP levels in obese Korean women.

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