Abstract
Objective Lipocalin family proteins, including adipocyte fatty acid-binding protein (A-FABP), lipocalin-2 and retinol-binding protein 4 (RBP4), have recently been identified as novel adipokines associated with obesity, type 2 diabetes and the metabolic syndrome. We have evaluated the effect of exercise training on lipocalin family proteins and inflammatory markers. Study subjects Thirty obese Korean women and 15 age-matched nonobese control subjects were studied. Design Concentrations of the lipocalin family proteins were compared between obese and nonobese women and were evaluated before and 3 months after an exercise programme consisting of aerobic exercise (45 min/session, 300 kcal/day) and muscle strength training (20 min/session, 100 kcal/day) five times a week. Results Obese women exhibited higher A-FABP levels compared to nonobese women (21·4 ± 6·4 μg/l vs. 13·6 ± 4·4 μg/l, P < 0·001). However, neither lipocalin-2 nor RBP4 levels were significantly different between the two groups, although the difference in lipocalin-2 was marginally significant (P = 0·054). Circulating A-FABP levels were significantly associated with body mass index (BMI), waist circumference, triglyceride, alanine aminotransferase (ALT), lipocalin-2 and high-sensitivity C-reactive protein (hsCRP) levels. After 3 months of the exercise training programme, serum A-FABP levels decreased significantly from 21·4 ± 6·4 μg/l to 19·3 ± 6·8 μg/l (P = 0·038), along with a reduction in weight, BMI, waist circumference, fasting glucose and total cholesterol levels. There was no significant change in the lipocalin-2 and RBP4 levels, although IL-6 levels increased after the exercise programme. Conclusion Exercise training with weight loss induced a significant reduction in circulating A-FABP levels in obese Korean women.
| Original language | English |
|---|---|
| Pages (from-to) | 569-574 |
| Number of pages | 6 |
| Journal | Clinical Endocrinology |
| Volume | 70 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2009 Apr 1 |
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ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
Cite this
Effect of exercise training on A-FABP, lipocalin-2 and RBP4 levels in obese women. / Choi, Kyung Mook; Kim, T. N.; Yoo, Hye-Jin; Lee, K. W.; Cho, Geum-Joon; Hwang, T. G.; Baik, Sei-Hyun; Choi, D. S.; Kim, Seon Mee.
In: Clinical Endocrinology, Vol. 70, No. 4, 01.04.2009, p. 569-574.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of exercise training on A-FABP, lipocalin-2 and RBP4 levels in obese women
AU - Choi, Kyung Mook
AU - Kim, T. N.
AU - Yoo, Hye-Jin
AU - Lee, K. W.
AU - Cho, Geum-Joon
AU - Hwang, T. G.
AU - Baik, Sei-Hyun
AU - Choi, D. S.
AU - Kim, Seon Mee
PY - 2009/4/1
Y1 - 2009/4/1
N2 - Objective Lipocalin family proteins, including adipocyte fatty acid-binding protein (A-FABP), lipocalin-2 and retinol-binding protein 4 (RBP4), have recently been identified as novel adipokines associated with obesity, type 2 diabetes and the metabolic syndrome. We have evaluated the effect of exercise training on lipocalin family proteins and inflammatory markers. Study subjects Thirty obese Korean women and 15 age-matched nonobese control subjects were studied. Design Concentrations of the lipocalin family proteins were compared between obese and nonobese women and were evaluated before and 3 months after an exercise programme consisting of aerobic exercise (45 min/session, 300 kcal/day) and muscle strength training (20 min/session, 100 kcal/day) five times a week. Results Obese women exhibited higher A-FABP levels compared to nonobese women (21·4 ± 6·4 μg/l vs. 13·6 ± 4·4 μg/l, P < 0·001). However, neither lipocalin-2 nor RBP4 levels were significantly different between the two groups, although the difference in lipocalin-2 was marginally significant (P = 0·054). Circulating A-FABP levels were significantly associated with body mass index (BMI), waist circumference, triglyceride, alanine aminotransferase (ALT), lipocalin-2 and high-sensitivity C-reactive protein (hsCRP) levels. After 3 months of the exercise training programme, serum A-FABP levels decreased significantly from 21·4 ± 6·4 μg/l to 19·3 ± 6·8 μg/l (P = 0·038), along with a reduction in weight, BMI, waist circumference, fasting glucose and total cholesterol levels. There was no significant change in the lipocalin-2 and RBP4 levels, although IL-6 levels increased after the exercise programme. Conclusion Exercise training with weight loss induced a significant reduction in circulating A-FABP levels in obese Korean women.
AB - Objective Lipocalin family proteins, including adipocyte fatty acid-binding protein (A-FABP), lipocalin-2 and retinol-binding protein 4 (RBP4), have recently been identified as novel adipokines associated with obesity, type 2 diabetes and the metabolic syndrome. We have evaluated the effect of exercise training on lipocalin family proteins and inflammatory markers. Study subjects Thirty obese Korean women and 15 age-matched nonobese control subjects were studied. Design Concentrations of the lipocalin family proteins were compared between obese and nonobese women and were evaluated before and 3 months after an exercise programme consisting of aerobic exercise (45 min/session, 300 kcal/day) and muscle strength training (20 min/session, 100 kcal/day) five times a week. Results Obese women exhibited higher A-FABP levels compared to nonobese women (21·4 ± 6·4 μg/l vs. 13·6 ± 4·4 μg/l, P < 0·001). However, neither lipocalin-2 nor RBP4 levels were significantly different between the two groups, although the difference in lipocalin-2 was marginally significant (P = 0·054). Circulating A-FABP levels were significantly associated with body mass index (BMI), waist circumference, triglyceride, alanine aminotransferase (ALT), lipocalin-2 and high-sensitivity C-reactive protein (hsCRP) levels. After 3 months of the exercise training programme, serum A-FABP levels decreased significantly from 21·4 ± 6·4 μg/l to 19·3 ± 6·8 μg/l (P = 0·038), along with a reduction in weight, BMI, waist circumference, fasting glucose and total cholesterol levels. There was no significant change in the lipocalin-2 and RBP4 levels, although IL-6 levels increased after the exercise programme. Conclusion Exercise training with weight loss induced a significant reduction in circulating A-FABP levels in obese Korean women.
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UR - http://www.scopus.com/inward/citedby.url?scp=61449115949&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2265.2008.03374.x
DO - 10.1111/j.1365-2265.2008.03374.x
M3 - Article
C2 - 18710473
AN - SCOPUS:61449115949
VL - 70
SP - 569
EP - 574
JO - Clinical Endocrinology
JF - Clinical Endocrinology
SN - 0300-0664
IS - 4
ER -