Effect of exercise training on plasma visfatin and eotaxin levels

Research output: Contribution to journalArticle

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Abstract

Objective: Visfatin, a novel adipokine, was revealed to be associated with obesity and to have insulinmimetic effect. Eotaxin, which is an important chemokine in asthma, was recently reported to be associated with obesity in mice and humans. We evaluated the effect of exercise training on plasma visfatin and eotaxin levels in association with cardiovascular risk factors. Design: Forty-eight non-diabetic Korean women were evaluated before and after a 12 week exercise program including aerobic exercise (45 min/ session, 300 Kcal/day) and muscle strength training (20 min/session, 100 Kcal/day) five times per week. Results: Plasma visfatin concentrations were elevated in obese subjects (body mass index, BMI≥25 kg/m2) when compared with non-obese subjects (16.4±13.4 ng/ml vs 7.7± 5.2ng/ml, P = 0.006), and eotaxin concentrations were elevated in subjects with central obesity (waist circumference, WC ≥80 cm) when compared with those without central obesity (73.6±17.8 pg/ml vs 64.2±4.2 pg/ml, P = 0.005). In multiple regression analyses, visfatin levels were associated with BMI (R2=0.255) and eotaxin levels were associated with WC and body weight (R2=0.307). After the exercise program, body weight, blood pressure, fasting glucose, and insulin resistance of participants were decreased. Furthermore, plasma visfatin levels were significantly decreased from 13.6±12.0 to 7.7±7.9 ng/ml (P = 0.026) and eotaxin levels were reduced from 72.0±16.7 to 66.9±14.2 pg/ml (P = 0.018). Conclusions: Exercise training with weight loss induced a significant reduction of plasma visfatin and eotaxin levels in non-diabetic Korean women.

Original languageEnglish
Pages (from-to)437-442
Number of pages6
JournalEuropean Journal of Endocrinology
Volume157
Issue number4
DOIs
Publication statusPublished - 2007 Oct 1

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Nicotinamide Phosphoribosyltransferase
Exercise
Abdominal Obesity
Obesity
Body Weight
Adipokines
Resistance Training
Muscle Strength
Waist Circumference
Chemokines
Insulin Resistance
Weight Loss
Fasting
Body Mass Index
Asthma
Regression Analysis
Blood Pressure
Glucose

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Effect of exercise training on plasma visfatin and eotaxin levels. / Choi, Kyung Mook; Kim, J. H.; Cho, Geum-Joon; Baik, Sei-Hyun; Park, H. S.; Kim, Seon Mee.

In: European Journal of Endocrinology, Vol. 157, No. 4, 01.10.2007, p. 437-442.

Research output: Contribution to journalArticle

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abstract = "Objective: Visfatin, a novel adipokine, was revealed to be associated with obesity and to have insulinmimetic effect. Eotaxin, which is an important chemokine in asthma, was recently reported to be associated with obesity in mice and humans. We evaluated the effect of exercise training on plasma visfatin and eotaxin levels in association with cardiovascular risk factors. Design: Forty-eight non-diabetic Korean women were evaluated before and after a 12 week exercise program including aerobic exercise (45 min/ session, 300 Kcal/day) and muscle strength training (20 min/session, 100 Kcal/day) five times per week. Results: Plasma visfatin concentrations were elevated in obese subjects (body mass index, BMI≥25 kg/m2) when compared with non-obese subjects (16.4±13.4 ng/ml vs 7.7± 5.2ng/ml, P = 0.006), and eotaxin concentrations were elevated in subjects with central obesity (waist circumference, WC ≥80 cm) when compared with those without central obesity (73.6±17.8 pg/ml vs 64.2±4.2 pg/ml, P = 0.005). In multiple regression analyses, visfatin levels were associated with BMI (R2=0.255) and eotaxin levels were associated with WC and body weight (R2=0.307). After the exercise program, body weight, blood pressure, fasting glucose, and insulin resistance of participants were decreased. Furthermore, plasma visfatin levels were significantly decreased from 13.6±12.0 to 7.7±7.9 ng/ml (P = 0.026) and eotaxin levels were reduced from 72.0±16.7 to 66.9±14.2 pg/ml (P = 0.018). Conclusions: Exercise training with weight loss induced a significant reduction of plasma visfatin and eotaxin levels in non-diabetic Korean women.",
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