Effect of fresh gas flow on isoflurane concentrations during low-flow anaesthesia

J. Y. Park, Jae Hwan Kim, Woon Young Kim, M. S. Chang, J. Y. Kim, Hye Won Shin

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3 Citations (Scopus)

Abstract

The effect of fresh gas flow (FGF) on isoflurane concentrations at given vaporizer settings during low-flow anaesthesia was investigated. Ninety patients (American Society of Anaesthesiologists physical status I or II) were randomly allocated to three groups (FGF 1 l/min, FGF 2 l/min and FGF 4 l/min). Anaesthesia was maintained for 10 min with vaporizer setting isoflurane 2 vol% and FGF 4 l/min for full-tissue anaesthetic uptake in a semi-closed circle system. Low-flow anaesthesia was maintained for 20 min with end-tidal isoflurane 1.5 vol% and FGF 2 l/min. FGF was then changed to FGF 1 l/min, FGF 2 l/min or FGF 4 l/min. Measurements during the 20-min period showed that inspired and end-tidal isoflurane concentrations decreased in the FGF 1-l/min group but increased in the FGF 4-l/min group compared with baseline values. No haemodynamic changes were observed. Monitoring of anaesthetic concentrations and appropriate control of vaporizer settings are necessary during low-flow anaesthesia.

Original languageEnglish
Pages (from-to)513-519
Number of pages7
JournalJournal of International Medical Research
Volume33
Issue number5
DOIs
Publication statusPublished - 2005 Jan 1

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Keywords

  • Breathing systems
  • End-tidal concentration
  • Fresh gas flow
  • Haemodynamic changes
  • Isoflurane
  • Low-flow anaesthesia
  • Vaporizer setting

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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