Effect of granulocyte colony-stimulating factor on chemotherapeutic activity of cytosine arabinoside in acute leukemic cell lines

Kwang Eun Cha, Soo-Young Yoon, Kap No Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Recent studies have shown the presence of receptors for granulocyte colony-stimulating factor (G-CSF) on lymphoid leukemic cells. To determine the effect of G-CSF on chemotherapeutic activity of cytosine arabinoside (Ara-C) on lymphoid as well as myeloid leukemic cells, we evaluated cell counts, apoptosis, and growth inhibition in HL-60, KG-1, Molt-4, Jijoye, and CCRF-CEM cell lines after incubation with Ara-C (0.1 and 1 μmol/L) and/or 5 ng/mL G-CSF. G-CSF potentiated the effect of Ara-C on 2 of 3 lymphoid leukemic cell lines (Molt-4 and Jijoye), whereas it decreased the apoptosis and the effect of Ara-C on mveloid cell lines (HL-60 and KG-1).

Original languageEnglish
Pages (from-to)199-205
Number of pages7
JournalInternational Journal of Hematology
Volume73
Issue number2
DOIs
Publication statusPublished - 2001

Fingerprint

Cytarabine
Granulocyte Colony-Stimulating Factor
Cell Line
Granulocyte Colony-Stimulating Factor Receptors
Lymphocytes
Apoptosis
Myeloid Cells
Cell Count
Growth

Keywords

  • Apoptosis
  • Cytosine arabinoside
  • Granulocyte colony-stimulating factor
  • Leukemic cell lines

ASJC Scopus subject areas

  • Hematology

Cite this

Effect of granulocyte colony-stimulating factor on chemotherapeutic activity of cytosine arabinoside in acute leukemic cell lines. / Cha, Kwang Eun; Yoon, Soo-Young; Lee, Kap No.

In: International Journal of Hematology, Vol. 73, No. 2, 2001, p. 199-205.

Research output: Contribution to journalArticle

@article{81c376d3d6424bd9ae18ebf1cd7008ef,
title = "Effect of granulocyte colony-stimulating factor on chemotherapeutic activity of cytosine arabinoside in acute leukemic cell lines",
abstract = "Recent studies have shown the presence of receptors for granulocyte colony-stimulating factor (G-CSF) on lymphoid leukemic cells. To determine the effect of G-CSF on chemotherapeutic activity of cytosine arabinoside (Ara-C) on lymphoid as well as myeloid leukemic cells, we evaluated cell counts, apoptosis, and growth inhibition in HL-60, KG-1, Molt-4, Jijoye, and CCRF-CEM cell lines after incubation with Ara-C (0.1 and 1 μmol/L) and/or 5 ng/mL G-CSF. G-CSF potentiated the effect of Ara-C on 2 of 3 lymphoid leukemic cell lines (Molt-4 and Jijoye), whereas it decreased the apoptosis and the effect of Ara-C on mveloid cell lines (HL-60 and KG-1).",
keywords = "Apoptosis, Cytosine arabinoside, Granulocyte colony-stimulating factor, Leukemic cell lines",
author = "Cha, {Kwang Eun} and Soo-Young Yoon and Lee, {Kap No}",
year = "2001",
doi = "10.1007/BF02981938",
language = "English",
volume = "73",
pages = "199--205",
journal = "International Journal of Hematology",
issn = "0925-5710",
publisher = "Springer Japan",
number = "2",

}

TY - JOUR

T1 - Effect of granulocyte colony-stimulating factor on chemotherapeutic activity of cytosine arabinoside in acute leukemic cell lines

AU - Cha, Kwang Eun

AU - Yoon, Soo-Young

AU - Lee, Kap No

PY - 2001

Y1 - 2001

N2 - Recent studies have shown the presence of receptors for granulocyte colony-stimulating factor (G-CSF) on lymphoid leukemic cells. To determine the effect of G-CSF on chemotherapeutic activity of cytosine arabinoside (Ara-C) on lymphoid as well as myeloid leukemic cells, we evaluated cell counts, apoptosis, and growth inhibition in HL-60, KG-1, Molt-4, Jijoye, and CCRF-CEM cell lines after incubation with Ara-C (0.1 and 1 μmol/L) and/or 5 ng/mL G-CSF. G-CSF potentiated the effect of Ara-C on 2 of 3 lymphoid leukemic cell lines (Molt-4 and Jijoye), whereas it decreased the apoptosis and the effect of Ara-C on mveloid cell lines (HL-60 and KG-1).

AB - Recent studies have shown the presence of receptors for granulocyte colony-stimulating factor (G-CSF) on lymphoid leukemic cells. To determine the effect of G-CSF on chemotherapeutic activity of cytosine arabinoside (Ara-C) on lymphoid as well as myeloid leukemic cells, we evaluated cell counts, apoptosis, and growth inhibition in HL-60, KG-1, Molt-4, Jijoye, and CCRF-CEM cell lines after incubation with Ara-C (0.1 and 1 μmol/L) and/or 5 ng/mL G-CSF. G-CSF potentiated the effect of Ara-C on 2 of 3 lymphoid leukemic cell lines (Molt-4 and Jijoye), whereas it decreased the apoptosis and the effect of Ara-C on mveloid cell lines (HL-60 and KG-1).

KW - Apoptosis

KW - Cytosine arabinoside

KW - Granulocyte colony-stimulating factor

KW - Leukemic cell lines

UR - http://www.scopus.com/inward/record.url?scp=0035260175&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035260175&partnerID=8YFLogxK

U2 - 10.1007/BF02981938

DO - 10.1007/BF02981938

M3 - Article

VL - 73

SP - 199

EP - 205

JO - International Journal of Hematology

JF - International Journal of Hematology

SN - 0925-5710

IS - 2

ER -