Effect of granulocyte colony-stimulating factor on chemotherapeutic activity of cytosine arabinoside in acute leukemic cell lines

Kwang Eun Cha, Soo Young Yoon, Kap No Lee

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Recent studies have shown the presence of receptors for granulocyte colony-stimulating factor (G-CSF) on lymphoid leukemic cells. To determine the effect of G-CSF on chemotherapeutic activity of cytosine arabinoside (Ara-C) on lymphoid as well as myeloid leukemic cells, we evaluated cell counts, apoptosis, and growth inhibition in HL-60, KG-1, Molt-4, Jijoye, and CCRF-CEM cell lines after incubation with Ara-C (0.1 and 1 μmol/L) and/or 5 ng/mL G-CSF. G-CSF potentiated the effect of Ara-C on 2 of 3 lymphoid leukemic cell lines (Molt-4 and Jijoye), whereas it decreased the apoptosis and the effect of Ara-C on mveloid cell lines (HL-60 and KG-1).

Original languageEnglish
Pages (from-to)199-205
Number of pages7
JournalInternational Journal of Hematology
Volume73
Issue number2
DOIs
Publication statusPublished - 2001

Keywords

  • Apoptosis
  • Cytosine arabinoside
  • Granulocyte colony-stimulating factor
  • Leukemic cell lines

ASJC Scopus subject areas

  • Hematology

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