Abstract
Recent studies have shown the presence of receptors for granulocyte colony-stimulating factor (G-CSF) on lymphoid leukemic cells. To determine the effect of G-CSF on chemotherapeutic activity of cytosine arabinoside (Ara-C) on lymphoid as well as myeloid leukemic cells, we evaluated cell counts, apoptosis, and growth inhibition in HL-60, KG-1, Molt-4, Jijoye, and CCRF-CEM cell lines after incubation with Ara-C (0.1 and 1 μmol/L) and/or 5 ng/mL G-CSF. G-CSF potentiated the effect of Ara-C on 2 of 3 lymphoid leukemic cell lines (Molt-4 and Jijoye), whereas it decreased the apoptosis and the effect of Ara-C on mveloid cell lines (HL-60 and KG-1).
| Original language | English |
|---|---|
| Pages (from-to) | 199-205 |
| Number of pages | 7 |
| Journal | International Journal of Hematology |
| Volume | 73 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2001 |
Keywords
- Apoptosis
- Cytosine arabinoside
- Granulocyte colony-stimulating factor
- Leukemic cell lines
ASJC Scopus subject areas
- Hematology