Effect of high intensity focused ultrasound (HIFU) in conjunction with a nanomedicines-microbubble complex for enhanced drug delivery

Hyounkoo Han, Hohyeon Lee, Kwang Meyung Kim, Hyuncheol Kim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Although nanomedicines have been intensively investigated for cancer therapy in the past, poor accumulation of nanomedicines in tumor sites remains a serious problem. Therefore, a novel drug delivery system is required to enhance accumulation and penetration of nanomedicines at the tumor site. Recently, high-intensity focused ultrasound (HIFU) has been highlighted as a non-invasive therapeutic modality, and showed enhanced therapeutic efficacy in combination with nanomedicines. Cavitation effect induced by the combination of HIFU and microbubbles results in transiently enhanced cell membrane permeability, facilitating improved drug delivery efficiency into tumor sites. Therefore, we introduce the acoustic cavitation and thermal/mechanical effects of HIFU in conjunction with microbubble to overcome the limitation of conventional drug delivery. The cavitation effect maximized by the strong acoustic energy of HIFU induced the preferential accumulation of nanomedicine locally released from the nanomedicines-microbubble complex in the tumor. In addition, the mechanical effect of HIFU allowed the accumulated nanomedicines to penetrate into deeper tumor region. The preferential accumulation and deeper penetration of nanomedicines by HIFU showed enhanced therapeutic efficacy, compared to low frequency ultrasound (US). These overall results demonstrate that the strategy combined nanomedicines-microbubble complex with HIFU is a promising tools for cancer therapy.

Original languageEnglish
Pages (from-to)75-86
Number of pages12
JournalJournal of Controlled Release
Volume266
DOIs
Publication statusPublished - 2017 Nov 28

Fingerprint

Nanomedicine
Microbubbles
Pharmaceutical Preparations
Neoplasms
Acoustics
Cell Membrane Permeability
Therapeutics
Drug Delivery Systems
Hot Temperature

Keywords

  • Cavitation effect
  • High-intensity focused ultrasound
  • Human serum albumin
  • Microbubbles
  • Nanoparticle
  • Paclitaxel

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Effect of high intensity focused ultrasound (HIFU) in conjunction with a nanomedicines-microbubble complex for enhanced drug delivery. / Han, Hyounkoo; Lee, Hohyeon; Kim, Kwang Meyung; Kim, Hyuncheol.

In: Journal of Controlled Release, Vol. 266, 28.11.2017, p. 75-86.

Research output: Contribution to journalArticle

@article{da964b3066254ae5aaa08e738505b351,
title = "Effect of high intensity focused ultrasound (HIFU) in conjunction with a nanomedicines-microbubble complex for enhanced drug delivery",
abstract = "Although nanomedicines have been intensively investigated for cancer therapy in the past, poor accumulation of nanomedicines in tumor sites remains a serious problem. Therefore, a novel drug delivery system is required to enhance accumulation and penetration of nanomedicines at the tumor site. Recently, high-intensity focused ultrasound (HIFU) has been highlighted as a non-invasive therapeutic modality, and showed enhanced therapeutic efficacy in combination with nanomedicines. Cavitation effect induced by the combination of HIFU and microbubbles results in transiently enhanced cell membrane permeability, facilitating improved drug delivery efficiency into tumor sites. Therefore, we introduce the acoustic cavitation and thermal/mechanical effects of HIFU in conjunction with microbubble to overcome the limitation of conventional drug delivery. The cavitation effect maximized by the strong acoustic energy of HIFU induced the preferential accumulation of nanomedicine locally released from the nanomedicines-microbubble complex in the tumor. In addition, the mechanical effect of HIFU allowed the accumulated nanomedicines to penetrate into deeper tumor region. The preferential accumulation and deeper penetration of nanomedicines by HIFU showed enhanced therapeutic efficacy, compared to low frequency ultrasound (US). These overall results demonstrate that the strategy combined nanomedicines-microbubble complex with HIFU is a promising tools for cancer therapy.",
keywords = "Cavitation effect, High-intensity focused ultrasound, Human serum albumin, Microbubbles, Nanoparticle, Paclitaxel",
author = "Hyounkoo Han and Hohyeon Lee and Kim, {Kwang Meyung} and Hyuncheol Kim",
year = "2017",
month = "11",
day = "28",
doi = "10.1016/j.jconrel.2017.09.022",
language = "English",
volume = "266",
pages = "75--86",
journal = "Journal of Controlled Release",
issn = "0168-3659",
publisher = "Elsevier",

}

TY - JOUR

T1 - Effect of high intensity focused ultrasound (HIFU) in conjunction with a nanomedicines-microbubble complex for enhanced drug delivery

AU - Han, Hyounkoo

AU - Lee, Hohyeon

AU - Kim, Kwang Meyung

AU - Kim, Hyuncheol

PY - 2017/11/28

Y1 - 2017/11/28

N2 - Although nanomedicines have been intensively investigated for cancer therapy in the past, poor accumulation of nanomedicines in tumor sites remains a serious problem. Therefore, a novel drug delivery system is required to enhance accumulation and penetration of nanomedicines at the tumor site. Recently, high-intensity focused ultrasound (HIFU) has been highlighted as a non-invasive therapeutic modality, and showed enhanced therapeutic efficacy in combination with nanomedicines. Cavitation effect induced by the combination of HIFU and microbubbles results in transiently enhanced cell membrane permeability, facilitating improved drug delivery efficiency into tumor sites. Therefore, we introduce the acoustic cavitation and thermal/mechanical effects of HIFU in conjunction with microbubble to overcome the limitation of conventional drug delivery. The cavitation effect maximized by the strong acoustic energy of HIFU induced the preferential accumulation of nanomedicine locally released from the nanomedicines-microbubble complex in the tumor. In addition, the mechanical effect of HIFU allowed the accumulated nanomedicines to penetrate into deeper tumor region. The preferential accumulation and deeper penetration of nanomedicines by HIFU showed enhanced therapeutic efficacy, compared to low frequency ultrasound (US). These overall results demonstrate that the strategy combined nanomedicines-microbubble complex with HIFU is a promising tools for cancer therapy.

AB - Although nanomedicines have been intensively investigated for cancer therapy in the past, poor accumulation of nanomedicines in tumor sites remains a serious problem. Therefore, a novel drug delivery system is required to enhance accumulation and penetration of nanomedicines at the tumor site. Recently, high-intensity focused ultrasound (HIFU) has been highlighted as a non-invasive therapeutic modality, and showed enhanced therapeutic efficacy in combination with nanomedicines. Cavitation effect induced by the combination of HIFU and microbubbles results in transiently enhanced cell membrane permeability, facilitating improved drug delivery efficiency into tumor sites. Therefore, we introduce the acoustic cavitation and thermal/mechanical effects of HIFU in conjunction with microbubble to overcome the limitation of conventional drug delivery. The cavitation effect maximized by the strong acoustic energy of HIFU induced the preferential accumulation of nanomedicine locally released from the nanomedicines-microbubble complex in the tumor. In addition, the mechanical effect of HIFU allowed the accumulated nanomedicines to penetrate into deeper tumor region. The preferential accumulation and deeper penetration of nanomedicines by HIFU showed enhanced therapeutic efficacy, compared to low frequency ultrasound (US). These overall results demonstrate that the strategy combined nanomedicines-microbubble complex with HIFU is a promising tools for cancer therapy.

KW - Cavitation effect

KW - High-intensity focused ultrasound

KW - Human serum albumin

KW - Microbubbles

KW - Nanoparticle

KW - Paclitaxel

UR - http://www.scopus.com/inward/record.url?scp=85029717852&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029717852&partnerID=8YFLogxK

U2 - 10.1016/j.jconrel.2017.09.022

DO - 10.1016/j.jconrel.2017.09.022

M3 - Article

C2 - 28928042

AN - SCOPUS:85029717852

VL - 266

SP - 75

EP - 86

JO - Journal of Controlled Release

JF - Journal of Controlled Release

SN - 0168-3659

ER -