Abstract
In vitro cell behaviors of calvarial osteoblasts (MC3T3) were evaluated by seeding them on both the surface and inside of in situ hyaluronic acid-poly(ethylene oxide) (HA-PEO) hydrogel, either after or before incorporation of mixture micro-particles of hydroxyapatite-β-tricalcium phosphate on/inside the hydrogel, respectively. Cellular behaviors such as adhesion and proliferation on the surface and inside the gel were evaluated with light microscopy and a microplate reader by focusing on the interactions of cell-HA-PEO as well as cell-hydroxyapatite-tricalcium phosphate micro-particle surface in the gel. Cell adhesion and spreading seemed to be enhanced by supplying the micro-particles to the inside the HA-PEO hydrogel, compared to the results of the HA-PEO hydrogel itself.
| Original language | English |
|---|---|
| Pages (from-to) | 765-768 |
| Number of pages | 4 |
| Journal | Key Engineering Materials |
| Volume | 342-343 |
| Publication status | Published - 2007 Apr 16 |
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Keywords
- Bone cell interaction
- Hyaluronic acid
- Hydroxyapatite
- Poly(ethylene oxide)
- Tricalcium phosphate
ASJC Scopus subject areas
- Ceramics and Composites
- Chemical Engineering (miscellaneous)
Cite this
Effect of hydroxyapatite-tricalcium phosphate micro-particles on the cellular interaction of in situ hyaluronic acid-poly(ethylene oxide) hydrogel. / Kim, Mi Sook; Choi, Yoon Jeong; Kim, Gun Woo; Noh, Insup; Park, Yongdoo; Lee, Kyu Back; Kim, In Sook; Hwang, Soon Jung.
In: Key Engineering Materials, Vol. 342-343, 16.04.2007, p. 765-768.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of hydroxyapatite-tricalcium phosphate micro-particles on the cellular interaction of in situ hyaluronic acid-poly(ethylene oxide) hydrogel
AU - Kim, Mi Sook
AU - Choi, Yoon Jeong
AU - Kim, Gun Woo
AU - Noh, Insup
AU - Park, Yongdoo
AU - Lee, Kyu Back
AU - Kim, In Sook
AU - Hwang, Soon Jung
PY - 2007/4/16
Y1 - 2007/4/16
N2 - In vitro cell behaviors of calvarial osteoblasts (MC3T3) were evaluated by seeding them on both the surface and inside of in situ hyaluronic acid-poly(ethylene oxide) (HA-PEO) hydrogel, either after or before incorporation of mixture micro-particles of hydroxyapatite-β-tricalcium phosphate on/inside the hydrogel, respectively. Cellular behaviors such as adhesion and proliferation on the surface and inside the gel were evaluated with light microscopy and a microplate reader by focusing on the interactions of cell-HA-PEO as well as cell-hydroxyapatite-tricalcium phosphate micro-particle surface in the gel. Cell adhesion and spreading seemed to be enhanced by supplying the micro-particles to the inside the HA-PEO hydrogel, compared to the results of the HA-PEO hydrogel itself.
AB - In vitro cell behaviors of calvarial osteoblasts (MC3T3) were evaluated by seeding them on both the surface and inside of in situ hyaluronic acid-poly(ethylene oxide) (HA-PEO) hydrogel, either after or before incorporation of mixture micro-particles of hydroxyapatite-β-tricalcium phosphate on/inside the hydrogel, respectively. Cellular behaviors such as adhesion and proliferation on the surface and inside the gel were evaluated with light microscopy and a microplate reader by focusing on the interactions of cell-HA-PEO as well as cell-hydroxyapatite-tricalcium phosphate micro-particle surface in the gel. Cell adhesion and spreading seemed to be enhanced by supplying the micro-particles to the inside the HA-PEO hydrogel, compared to the results of the HA-PEO hydrogel itself.
KW - Bone cell interaction
KW - Hyaluronic acid
KW - Hydroxyapatite
KW - Poly(ethylene oxide)
KW - Tricalcium phosphate
UR - http://www.scopus.com/inward/record.url?scp=34147158957&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34147158957&partnerID=8YFLogxK
M3 - Article
VL - 342-343
SP - 765
EP - 768
JO - Key Engineering Materials
JF - Key Engineering Materials
SN - 1013-9826
ER -