Effect of hydroxyapatite-tricalcium phosphate micro-particles on the cellular interaction of in situ hyaluronic acid-poly(ethylene oxide) hydrogel

Mi Sook Kim; Yoon Jeong Choi; Gun Woo Kim; Insup Noh; Yongdoo Park; Kyu Back Lee; In Sook Kim; Soon Jung Hwang

doi:10.4028/0-87849-436-7.765

Effect of hydroxyapatite-tricalcium phosphate micro-particles on the cellular interaction of in situ hyaluronic acid-poly(ethylene oxide) hydrogel

Mi Sook Kim, Yoon Jeong Choi, Gun Woo Kim, Insup Noh, Yongdoo Park, Kyu Back Lee, In Sook Kim, Soon Jung Hwang

Research output: Contribution to journal › Article › peer-review

Abstract

In vitro cell behaviors of calvarial osteoblasts (MC3T3) were evaluated by seeding them on both the surface and inside of in situ hyaluronic acid-poly(ethylene oxide) (HA-PEO) hydrogel, either after or before incorporation of mixture micro-particles of hydroxyapatite-β-tricalcium phosphate on/inside the hydrogel, respectively. Cellular behaviors such as adhesion and proliferation on the surface and inside the gel were evaluated with light microscopy and a microplate reader by focusing on the interactions of cell-HA-PEO as well as cell-hydroxyapatite-tricalcium phosphate micro-particle surface in the gel. Cell adhesion and spreading seemed to be enhanced by supplying the micro-particles to the inside the HA-PEO hydrogel, compared to the results of the HA-PEO hydrogel itself.

Original language	English
Pages (from-to)	765-768
Number of pages	4
Journal	Key Engineering Materials
Volume	342-343
DOIs	https://doi.org/10.4028/0-87849-436-7.765
Publication status	Published - 2007

Keywords

Bone cell interaction
Hyaluronic acid
Hydroxyapatite
Poly(ethylene oxide)
Tricalcium phosphate

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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Effect of hydroxyapatite-tricalcium phosphate micro-particles on the cellular interaction of in situ hyaluronic acid-poly(ethylene oxide) hydrogel. / Kim, Mi Sook; Choi, Yoon Jeong; Kim, Gun Woo; Noh, Insup; Park, Yongdoo ; Lee, Kyu Back; Kim, In Sook; Hwang, Soon Jung.

In: Key Engineering Materials, Vol. 342-343, 2007, p. 765-768.

Research output: Contribution to journal › Article › peer-review

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title = "Effect of hydroxyapatite-tricalcium phosphate micro-particles on the cellular interaction of in situ hyaluronic acid-poly(ethylene oxide) hydrogel",

abstract = "In vitro cell behaviors of calvarial osteoblasts (MC3T3) were evaluated by seeding them on both the surface and inside of in situ hyaluronic acid-poly(ethylene oxide) (HA-PEO) hydrogel, either after or before incorporation of mixture micro-particles of hydroxyapatite-β-tricalcium phosphate on/inside the hydrogel, respectively. Cellular behaviors such as adhesion and proliferation on the surface and inside the gel were evaluated with light microscopy and a microplate reader by focusing on the interactions of cell-HA-PEO as well as cell-hydroxyapatite-tricalcium phosphate micro-particle surface in the gel. Cell adhesion and spreading seemed to be enhanced by supplying the micro-particles to the inside the HA-PEO hydrogel, compared to the results of the HA-PEO hydrogel itself.",

keywords = "Bone cell interaction, Hyaluronic acid, Hydroxyapatite, Poly(ethylene oxide), Tricalcium phosphate",

author = "Kim, {Mi Sook} and Choi, {Yoon Jeong} and Kim, {Gun Woo} and Insup Noh and Yongdoo Park and Lee, {Kyu Back} and Kim, {In Sook} and Hwang, {Soon Jung}",

year = "2007",

doi = "10.4028/0-87849-436-7.765",

language = "English",

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AU - Kim, Mi Sook

AU - Choi, Yoon Jeong

AU - Kim, Gun Woo

AU - Noh, Insup

AU - Park, Yongdoo

AU - Lee, Kyu Back

AU - Kim, In Sook

AU - Hwang, Soon Jung

PY - 2007

Y1 - 2007

N2 - In vitro cell behaviors of calvarial osteoblasts (MC3T3) were evaluated by seeding them on both the surface and inside of in situ hyaluronic acid-poly(ethylene oxide) (HA-PEO) hydrogel, either after or before incorporation of mixture micro-particles of hydroxyapatite-β-tricalcium phosphate on/inside the hydrogel, respectively. Cellular behaviors such as adhesion and proliferation on the surface and inside the gel were evaluated with light microscopy and a microplate reader by focusing on the interactions of cell-HA-PEO as well as cell-hydroxyapatite-tricalcium phosphate micro-particle surface in the gel. Cell adhesion and spreading seemed to be enhanced by supplying the micro-particles to the inside the HA-PEO hydrogel, compared to the results of the HA-PEO hydrogel itself.

AB - In vitro cell behaviors of calvarial osteoblasts (MC3T3) were evaluated by seeding them on both the surface and inside of in situ hyaluronic acid-poly(ethylene oxide) (HA-PEO) hydrogel, either after or before incorporation of mixture micro-particles of hydroxyapatite-β-tricalcium phosphate on/inside the hydrogel, respectively. Cellular behaviors such as adhesion and proliferation on the surface and inside the gel were evaluated with light microscopy and a microplate reader by focusing on the interactions of cell-HA-PEO as well as cell-hydroxyapatite-tricalcium phosphate micro-particle surface in the gel. Cell adhesion and spreading seemed to be enhanced by supplying the micro-particles to the inside the HA-PEO hydrogel, compared to the results of the HA-PEO hydrogel itself.

KW - Bone cell interaction

KW - Hyaluronic acid

KW - Hydroxyapatite

KW - Poly(ethylene oxide)

KW - Tricalcium phosphate

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JO - Key Engineering Materials

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SN - 1013-9826

ER -

Effect of hydroxyapatite-tricalcium phosphate micro-particles on the cellular interaction of in situ hyaluronic acid-poly(ethylene oxide) hydrogel

Abstract

Keywords

ASJC Scopus subject areas

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