Effect of hydroxyapatite-tricalcium phosphate micro-particles on the cellular interaction of in situ hyaluronic acid-poly(ethylene oxide) hydrogel

Mi Sook Kim, Yoon Jeong Choi, Gun Woo Kim, Insup Noh, Yongdoo Park, Kyu Back Lee, In Sook Kim, Soon Jung Hwang

Research output: Contribution to journalArticle

Abstract

In vitro cell behaviors of calvarial osteoblasts (MC3T3) were evaluated by seeding them on both the surface and inside of in situ hyaluronic acid-poly(ethylene oxide) (HA-PEO) hydrogel, either after or before incorporation of mixture micro-particles of hydroxyapatite-β-tricalcium phosphate on/inside the hydrogel, respectively. Cellular behaviors such as adhesion and proliferation on the surface and inside the gel were evaluated with light microscopy and a microplate reader by focusing on the interactions of cell-HA-PEO as well as cell-hydroxyapatite-tricalcium phosphate micro-particle surface in the gel. Cell adhesion and spreading seemed to be enhanced by supplying the micro-particles to the inside the HA-PEO hydrogel, compared to the results of the HA-PEO hydrogel itself.

Original languageEnglish
Pages (from-to)765-768
Number of pages4
JournalKey Engineering Materials
Volume342-343
DOIs
Publication statusPublished - 2007

Keywords

  • Bone cell interaction
  • Hyaluronic acid
  • Hydroxyapatite
  • Poly(ethylene oxide)
  • Tricalcium phosphate

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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