Abstract
In vitro cell behaviors of calvarial osteoblasts (MC3T3) were evaluated by seeding them on both the surface and inside of in situ hyaluronic acid-poly(ethylene oxide) (HA-PEO) hydrogel, either after or before incorporation of mixture micro-particles of hydroxyapatite-β-tricalcium phosphate on/inside the hydrogel, respectively. Cellular behaviors such as adhesion and proliferation on the surface and inside the gel were evaluated with light microscopy and a microplate reader by focusing on the interactions of cell-HA-PEO as well as cell-hydroxyapatite-tricalcium phosphate micro-particle surface in the gel. Cell adhesion and spreading seemed to be enhanced by supplying the micro-particles to the inside the HA-PEO hydrogel, compared to the results of the HA-PEO hydrogel itself.
| Original language | English |
|---|---|
| Pages (from-to) | 765-768 |
| Number of pages | 4 |
| Journal | Key Engineering Materials |
| Volume | 342-343 |
| DOIs | |
| Publication status | Published - 2007 |
Keywords
- Bone cell interaction
- Hyaluronic acid
- Hydroxyapatite
- Poly(ethylene oxide)
- Tricalcium phosphate
ASJC Scopus subject areas
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering