Effect of Hyper- and Hypocapnia on Cerebral Arterial Compliance in Normal Subjects

Emmanuel Carrera, Dong Ju Kim, Gianluca Castellani, Christian Zweifel, Peter Smielewski, John D. Pickard, Marek Czosnyka

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Changes in partial pressure of carbon dioxide (PaCO2) are associated with a decrease in cerebral blood flow (CBF) during hypocapnia and an increase in CBF during hypercapnia. However, the effects of changes in PaCO2 on cerebral arterial compliance (Ca) are unknown. METHODS: We assessed the changes in Ca in 20 normal subjects using monitoring of arterial blood pressure (ABP) and cerebral blood flow velocity (CBFV). Cerebral arterial blood volume (CaBV) was extracted from CBFV. Ca was defined as the ratio between the pulse amplitudes of CaBV (AMPCaBV) and ABP (AMPABP). All parameters were recorded during normo-, hyper-, and hypocapnia. RESULTS: During hypocapnia, Ca was significantly lower than during normocapnia (10 ± .04 vs .17 ± .06; P < .001) secondary to a decrease in AMPCaBV (1.3 ± .4 vs. 1.9 ± .5; P < .001) and a concomitant increase in AMPABP (13.8 ± 3.4 vs. 11.6 ± 1.7 mmHg; P<.001). During hypercapnia, there was no change in Ca compared with normocapnia. Ca was inversely correlated with the cerebrovascular resistance during hypo- (R2= 0.86; P<.001), and hypercapnia (R2= 0.61; P<.001). CONCLUSION: Using a new mathematical model, we have described a reduction of Ca during hypocapnia. Further studies are needed to determine whether Ca may be an independent predictor of outcome in pathological conditions.

Original languageEnglish
Pages (from-to)121-125
Number of pages5
JournalJournal of Neuroimaging
Volume21
Issue number2
DOIs
Publication statusPublished - 2011 Apr 1
Externally publishedYes

Fingerprint

Hypocapnia
Hypercapnia
Compliance
Cerebrovascular Circulation
Blood Flow Velocity
Partial Pressure
Carbon Dioxide
Pulse
Arterial Pressure
Theoretical Models

Keywords

  • Cerebral arterial blood volume
  • Cerebral arterial compliance
  • Hypocapnia
  • Transcranial Doppler

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Carrera, E., Kim, D. J., Castellani, G., Zweifel, C., Smielewski, P., Pickard, J. D., & Czosnyka, M. (2011). Effect of Hyper- and Hypocapnia on Cerebral Arterial Compliance in Normal Subjects. Journal of Neuroimaging, 21(2), 121-125. https://doi.org/10.1111/j.1552-6569.2009.00439.x

Effect of Hyper- and Hypocapnia on Cerebral Arterial Compliance in Normal Subjects. / Carrera, Emmanuel; Kim, Dong Ju; Castellani, Gianluca; Zweifel, Christian; Smielewski, Peter; Pickard, John D.; Czosnyka, Marek.

In: Journal of Neuroimaging, Vol. 21, No. 2, 01.04.2011, p. 121-125.

Research output: Contribution to journalArticle

Carrera, E, Kim, DJ, Castellani, G, Zweifel, C, Smielewski, P, Pickard, JD & Czosnyka, M 2011, 'Effect of Hyper- and Hypocapnia on Cerebral Arterial Compliance in Normal Subjects', Journal of Neuroimaging, vol. 21, no. 2, pp. 121-125. https://doi.org/10.1111/j.1552-6569.2009.00439.x
Carrera, Emmanuel ; Kim, Dong Ju ; Castellani, Gianluca ; Zweifel, Christian ; Smielewski, Peter ; Pickard, John D. ; Czosnyka, Marek. / Effect of Hyper- and Hypocapnia on Cerebral Arterial Compliance in Normal Subjects. In: Journal of Neuroimaging. 2011 ; Vol. 21, No. 2. pp. 121-125.
@article{64757f8c9bc14c9ab00ed50f992827b7,
title = "Effect of Hyper- and Hypocapnia on Cerebral Arterial Compliance in Normal Subjects",
abstract = "Changes in partial pressure of carbon dioxide (PaCO2) are associated with a decrease in cerebral blood flow (CBF) during hypocapnia and an increase in CBF during hypercapnia. However, the effects of changes in PaCO2 on cerebral arterial compliance (Ca) are unknown. METHODS: We assessed the changes in Ca in 20 normal subjects using monitoring of arterial blood pressure (ABP) and cerebral blood flow velocity (CBFV). Cerebral arterial blood volume (CaBV) was extracted from CBFV. Ca was defined as the ratio between the pulse amplitudes of CaBV (AMPCaBV) and ABP (AMPABP). All parameters were recorded during normo-, hyper-, and hypocapnia. RESULTS: During hypocapnia, Ca was significantly lower than during normocapnia (10 ± .04 vs .17 ± .06; P < .001) secondary to a decrease in AMPCaBV (1.3 ± .4 vs. 1.9 ± .5; P < .001) and a concomitant increase in AMPABP (13.8 ± 3.4 vs. 11.6 ± 1.7 mmHg; P<.001). During hypercapnia, there was no change in Ca compared with normocapnia. Ca was inversely correlated with the cerebrovascular resistance during hypo- (R2= 0.86; P<.001), and hypercapnia (R2= 0.61; P<.001). CONCLUSION: Using a new mathematical model, we have described a reduction of Ca during hypocapnia. Further studies are needed to determine whether Ca may be an independent predictor of outcome in pathological conditions.",
keywords = "Cerebral arterial blood volume, Cerebral arterial compliance, Hypocapnia, Transcranial Doppler",
author = "Emmanuel Carrera and Kim, {Dong Ju} and Gianluca Castellani and Christian Zweifel and Peter Smielewski and Pickard, {John D.} and Marek Czosnyka",
year = "2011",
month = "4",
day = "1",
doi = "10.1111/j.1552-6569.2009.00439.x",
language = "English",
volume = "21",
pages = "121--125",
journal = "Journal of Neuroimaging",
issn = "1051-2284",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Effect of Hyper- and Hypocapnia on Cerebral Arterial Compliance in Normal Subjects

AU - Carrera, Emmanuel

AU - Kim, Dong Ju

AU - Castellani, Gianluca

AU - Zweifel, Christian

AU - Smielewski, Peter

AU - Pickard, John D.

AU - Czosnyka, Marek

PY - 2011/4/1

Y1 - 2011/4/1

N2 - Changes in partial pressure of carbon dioxide (PaCO2) are associated with a decrease in cerebral blood flow (CBF) during hypocapnia and an increase in CBF during hypercapnia. However, the effects of changes in PaCO2 on cerebral arterial compliance (Ca) are unknown. METHODS: We assessed the changes in Ca in 20 normal subjects using monitoring of arterial blood pressure (ABP) and cerebral blood flow velocity (CBFV). Cerebral arterial blood volume (CaBV) was extracted from CBFV. Ca was defined as the ratio between the pulse amplitudes of CaBV (AMPCaBV) and ABP (AMPABP). All parameters were recorded during normo-, hyper-, and hypocapnia. RESULTS: During hypocapnia, Ca was significantly lower than during normocapnia (10 ± .04 vs .17 ± .06; P < .001) secondary to a decrease in AMPCaBV (1.3 ± .4 vs. 1.9 ± .5; P < .001) and a concomitant increase in AMPABP (13.8 ± 3.4 vs. 11.6 ± 1.7 mmHg; P<.001). During hypercapnia, there was no change in Ca compared with normocapnia. Ca was inversely correlated with the cerebrovascular resistance during hypo- (R2= 0.86; P<.001), and hypercapnia (R2= 0.61; P<.001). CONCLUSION: Using a new mathematical model, we have described a reduction of Ca during hypocapnia. Further studies are needed to determine whether Ca may be an independent predictor of outcome in pathological conditions.

AB - Changes in partial pressure of carbon dioxide (PaCO2) are associated with a decrease in cerebral blood flow (CBF) during hypocapnia and an increase in CBF during hypercapnia. However, the effects of changes in PaCO2 on cerebral arterial compliance (Ca) are unknown. METHODS: We assessed the changes in Ca in 20 normal subjects using monitoring of arterial blood pressure (ABP) and cerebral blood flow velocity (CBFV). Cerebral arterial blood volume (CaBV) was extracted from CBFV. Ca was defined as the ratio between the pulse amplitudes of CaBV (AMPCaBV) and ABP (AMPABP). All parameters were recorded during normo-, hyper-, and hypocapnia. RESULTS: During hypocapnia, Ca was significantly lower than during normocapnia (10 ± .04 vs .17 ± .06; P < .001) secondary to a decrease in AMPCaBV (1.3 ± .4 vs. 1.9 ± .5; P < .001) and a concomitant increase in AMPABP (13.8 ± 3.4 vs. 11.6 ± 1.7 mmHg; P<.001). During hypercapnia, there was no change in Ca compared with normocapnia. Ca was inversely correlated with the cerebrovascular resistance during hypo- (R2= 0.86; P<.001), and hypercapnia (R2= 0.61; P<.001). CONCLUSION: Using a new mathematical model, we have described a reduction of Ca during hypocapnia. Further studies are needed to determine whether Ca may be an independent predictor of outcome in pathological conditions.

KW - Cerebral arterial blood volume

KW - Cerebral arterial compliance

KW - Hypocapnia

KW - Transcranial Doppler

UR - http://www.scopus.com/inward/record.url?scp=79953041173&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953041173&partnerID=8YFLogxK

U2 - 10.1111/j.1552-6569.2009.00439.x

DO - 10.1111/j.1552-6569.2009.00439.x

M3 - Article

VL - 21

SP - 121

EP - 125

JO - Journal of Neuroimaging

JF - Journal of Neuroimaging

SN - 1051-2284

IS - 2

ER -