Effect of intracavitary injection of urokinase in the experimentally induced early pyogenic liver abscess of the rabbit

Tae Jin Song, Sang Hoon Cha, Baek Hyun Kim, Hwan Hoon Chung, Cheol Min Park, Jung Hyuck Kim, Il Ok Lee, Eun Sook Lee, Young Sik Kim, Daesu Kim, Jong Tae Park, Seung Joo Kim, Sang Yong Choi, Young Cheol Kim, Ng Ok Seo, Bum Hwan Koo

Research output: Contribution to journalArticle

Abstract

This study was carried out to assess the effects of intracavitary injection of urokinase in the early liver abscess (ELA) of the rabbits. ELAs were induced on 25 in 47 New Zealand rabbits, which were divided into two groups, with 15 in group A, and 10 in group B. Urokinase was injected into the ELA of group A, and normal physiologic saline into those of group B. One and a half hours after the injections, the rabbits were sacrificed and evaluated by pathologists for the degree of fibrosis of the ELA wall, and fibrinolysis in the ELA itself. Statistical analyses were performed between the two groups. The following ELA sizes for each group were obtained: Group A, 4.3 × 2.9-10.1 × 7.2 mm (mean 7.1 × 4.1 mm); Group B, 4.6 × 2.7-15.0 × 9.7 mm (mean 8.5 × 4.57 mm). Eleven (73%) in group A showed grade II fibrosis of ELA wall, and 8 (80%) in group B showed grade III fibrosis of ELA wall (p=0.002). On pathological analysis, 5 (46%) in group A showed grade II fibrin, and 8 (80%) in group B showed grade III fibrin, of the ELA (p=0.09). In conclusion, injection of urokinase, into the ELAs, can reduce the degree of fibrosis of abscess walls.

Original languageEnglish
Pages (from-to)341-345
Number of pages5
JournalYonsei medical journal
Volume43
Issue number3
DOIs
Publication statusPublished - 2002

Keywords

  • Liver
  • Liver abscess
  • Urokinase

ASJC Scopus subject areas

  • Medicine(all)

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    Song, T. J., Cha, S. H., Kim, B. H., Chung, H. H., Park, C. M., Kim, J. H., Lee, I. O., Lee, E. S., Kim, Y. S., Kim, D., Park, J. T., Kim, S. J., Choi, S. Y., Kim, Y. C., Seo, N. O., & Koo, B. H. (2002). Effect of intracavitary injection of urokinase in the experimentally induced early pyogenic liver abscess of the rabbit. Yonsei medical journal, 43(3), 341-345. https://doi.org/10.3349/ymj.2002.43.3.341