Effect of intrauterine growth retardation on the progression of nephrotic syndrome

Yo Won Na, Hae Joung Yang, Jeong Hoon Choi, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Background/Aim: Neonates with intrauterine growth retardation (IUGR) experience higher morbidity and mortality rates than appropriate-for-gestational-age (AGA) neonates. The purpose of our study was to clarify whether IUGR has any influences on the progression of nephrotic syndrome in children. Methods: We performed a retrospective review of 56 children with nephrotic syndrome. IUGR was defined as a birth weight less than the tenth percentile for gestational age. Among 56 patients having nephrotic syndrome, 8 had IUGR, and 48 were AGA. Results: The 24-hour urinary protein level in children with IUGR was significantly higher than that in children who were AGA (7.61 ± 6.75 vs. 3.92 ± 3.70 g/day, p < 0.05). There was a statistically significant difference in the incidence of steroid resistance (62.5 vs. 10.4%, p < 0.05) and in the time to remission (median 60 vs. 13 days, p < 0.05) between the children with IUGR and those being AGA. Also, there was a significant difference in the incidences of treatment with cytotoxic agents (75 vs. 29.2%, p < 0.05) and complications such as hypertension. Conclusions: Our report indicates that IUGR predicts an unfavorable progression of nephrotic syndrome. So, it is important for nephrologists to pay attention to the clinical course of nephrotic syndrome in neonates with IUGR.

Original languageEnglish
Pages (from-to)463-467
Number of pages5
JournalAmerican journal of nephrology
Volume22
Issue number5-6
DOIs
Publication statusPublished - 2002

Keywords

  • Cytotoxic agents
  • Hypertension
  • Intrauterine growth retardation
  • Nephrotic syndrome
  • Steroid resistance

ASJC Scopus subject areas

  • Nephrology

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