Effect of Long-Term Treatment with Fimasartan on Transient Focal Ischemia in Rat Brain

Chi Kyung Kim, Xiu Li Yang, Young Ju Kim, In Young Choi, Han Gil Jeong, Hong Kyun Park, Dohoung Kim, Tae Jung Kim, Hyunduk Jang, Sang Bae Ko, Byung Woo Yoon

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7 Citations (Scopus)

Abstract

Fimasartan is a newly developed angiotensin receptor blocker, which may have protective effects during myocardial infarction or atherosclerosis. In this context, we investigated the effects of long-term treatment with low-dose fimasartan on focal ischemia in rat brain. We induced focal ischemia in brain by transient intraluminal occlusion of middle cerebral artery (MCA) and administered low-dose (0.5 mg/kg) or regular doses (1 or 3 mg/kg) of fimasartan via intravenous routes. After the administration of low-dose (0.5 mg/kg) fimasartan, blood pressure did not decrease compared to the phosphate-buffered saline- (PBS-) control with MCA occlusion (MCAO) group. The infarct volume and ischemic cell death were reduced in the low-dose fimasartan-treated group (46 ± 41 mm3 for 0.5 mg/kg and 153 ± 47 mm3 for PBS-control with MCAO; P < 0.01) but not in the regular-dose groups. Low-dose fimasartan treatment improved functional recovery after ischemia and significantly decreased mortality. In our study, fimasartan reduced the degradation of IB and the formation of an inflammatory end-product, COX-2. As a result, the recruitment of inflammatory cells in the peri-infarct area decreased in fimasartan-treated group. We have demonstrated that long-term, low-dose fimasartan treatment improved outcomes after focal ischemia in the brain via a reduction of inflammation.

Original languageEnglish
Article number295925
JournalBioMed Research International
Volume2015
DOIs
Publication statusPublished - 2015 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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    Kim, C. K., Yang, X. L., Kim, Y. J., Choi, I. Y., Jeong, H. G., Park, H. K., Kim, D., Kim, T. J., Jang, H., Ko, S. B., & Yoon, B. W. (2015). Effect of Long-Term Treatment with Fimasartan on Transient Focal Ischemia in Rat Brain. BioMed Research International, 2015, [295925]. https://doi.org/10.1155/2015/295925