Effect of magnetic modulation of mitochondrial voltage-dependent anion channel 2 against beta-amyloid induced neurotoxicity

Sujin Lee, Junghoon Lee, Sang Jun Sim, Misun Cha

Research output: Contribution to journalArticle

Abstract

The magnetic capture of mitochondrial VDAC2 with bacterial magnetic particles (BMPs) conjugated VDAC2 antibody (BMPs-Ab) significantly decreased the expressed intracellular calcium levels and neurotoxicity induced by Aβ. This magnetic modulation of mitochondrial VDAC, playing a key role in various Ca<sup>2+</sup> flux pathways, should provide attractive targets for the future development of AD treatments.

Original languageEnglish
Pages (from-to)63681-63684
Number of pages4
JournalRSC Advances
Volume4
Issue number109
DOIs
Publication statusPublished - 2014

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Voltage-Dependent Anion Channel 2
Amyloid
Antibodies
Calcium
Negative ions
Modulation
Fluxes
Electric potential

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)

Cite this

Effect of magnetic modulation of mitochondrial voltage-dependent anion channel 2 against beta-amyloid induced neurotoxicity. / Lee, Sujin; Lee, Junghoon; Sim, Sang Jun; Cha, Misun.

In: RSC Advances, Vol. 4, No. 109, 2014, p. 63681-63684.

Research output: Contribution to journalArticle

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