Effect of maternal passive autoimmunization against myostatin on growth performance in chickens

Y. S. Moon, H. G. Lee, Y. H. Yin, X. Jin, Z. S. Hong, J. S. Cho, S. C. Kim, Seungkwon You, D. I. Jin, J. Y. Han, Y. J. Choi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Myostatin is a negative regulator of skeletal muscle growth and a loss of functional myostatin protein increases muscle hypertrophy and hyperplasia in cattle. The present study was conducted to investigate whether maternal passive immunization against myostatin would improve growth performance in chickens. A complete broiler myostatin cDNA was cloned and it was expressed into two transcripts as 1,128 bp and 985 bp by alternative splicing. A conjugated mature myostatin (350 bp) was used to induce autoimmunization and maternal passively immunized chickens was used for the experiment. It was confirmed that there was a maternal passive immunization against myostatin at zero weeks of age, but its effect was reduced by 6 weeks of age. The auto-immunized groups showed smaller body weights than those of control group during the growing period and the difference was getting bigger with time until 6 weeks of age. These results suggest that passive autoimmunization against myostatin used in this study is not potent enough to stimulate growth performance in chickens.

Original languageEnglish
Pages (from-to)1017-1021
Number of pages5
JournalAsian-Australasian Journal of Animal Sciences
Volume18
Issue number7
Publication statusPublished - 2005 Jul 1

Fingerprint

Myostatin
myostatin
maternal effect
Chickens
growth performance
Mothers
chickens
Growth
Passive Immunization
immunization
Muscle Proteins
alternative splicing
Alternative Splicing
hypertrophy
hyperplasia
automobiles
Hypertrophy
Hyperplasia
skeletal muscle
Skeletal Muscle

Keywords

  • Autoimmunization
  • Chicken
  • Growth
  • Muscle
  • Myostatin

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Moon, Y. S., Lee, H. G., Yin, Y. H., Jin, X., Hong, Z. S., Cho, J. S., ... Choi, Y. J. (2005). Effect of maternal passive autoimmunization against myostatin on growth performance in chickens. Asian-Australasian Journal of Animal Sciences, 18(7), 1017-1021.

Effect of maternal passive autoimmunization against myostatin on growth performance in chickens. / Moon, Y. S.; Lee, H. G.; Yin, Y. H.; Jin, X.; Hong, Z. S.; Cho, J. S.; Kim, S. C.; You, Seungkwon; Jin, D. I.; Han, J. Y.; Choi, Y. J.

In: Asian-Australasian Journal of Animal Sciences, Vol. 18, No. 7, 01.07.2005, p. 1017-1021.

Research output: Contribution to journalArticle

Moon, YS, Lee, HG, Yin, YH, Jin, X, Hong, ZS, Cho, JS, Kim, SC, You, S, Jin, DI, Han, JY & Choi, YJ 2005, 'Effect of maternal passive autoimmunization against myostatin on growth performance in chickens', Asian-Australasian Journal of Animal Sciences, vol. 18, no. 7, pp. 1017-1021.
Moon, Y. S. ; Lee, H. G. ; Yin, Y. H. ; Jin, X. ; Hong, Z. S. ; Cho, J. S. ; Kim, S. C. ; You, Seungkwon ; Jin, D. I. ; Han, J. Y. ; Choi, Y. J. / Effect of maternal passive autoimmunization against myostatin on growth performance in chickens. In: Asian-Australasian Journal of Animal Sciences. 2005 ; Vol. 18, No. 7. pp. 1017-1021.
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