Effect of microencapsulated precipitants of lactobacillus casei ATCC 393 on helicobacter pylori eradication

J. A. Ko, H. J. Lim, Hyun Jin Park

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Precipitants of Lactobacillus casei ATCC 393-loaded chitosan microspheres were prepared by electrostatic interaction between chitosan (CS) and poly-γ-glutamic acid (γ-PGA). The loading efficiency was approximately 80%, and the zeta potential of the microspheres became more positively charged as the molar ratio of the chitosan amino group was increased. The particles were confirmed to have a spherical shape by optical microscopy. A release test using simulated gastric fluid (SGF) was also performed. The results show that the precipitants were gradually released from the CS-γ-PGA microspheres at a rate of almost 80% after 60 min. Both the inhibition of Helicobacter pylori growth and the anti-adhesive activity of encapsulated precipitants were maintained after exposure to SGF. These results indicate that CS-γ-PGA microspheres may provide a delivery system for the effective eradication of H. pylori.

Original languageEnglish
Pages (from-to)631-635
Number of pages5
JournalProcess Biochemistry
Volume46
Issue number3
DOIs
Publication statusPublished - 2011 Mar 1

Fingerprint

Lactobacillus casei
Chitosan
Helicobacter pylori
Microspheres
Prostaglandins A
Stomach
Fluids
Zeta potential
Coulomb interactions
Static Electricity
Adhesives
Optical microscopy
Glutamic Acid
Microscopy
Acids
Growth

Keywords

  • Chitosan
  • Helicobacter pylori
  • Lactobacillus casei ATCC 393
  • Microspheres
  • Poly-γ-glutamic

ASJC Scopus subject areas

  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Bioengineering

Cite this

Effect of microencapsulated precipitants of lactobacillus casei ATCC 393 on helicobacter pylori eradication. / Ko, J. A.; Lim, H. J.; Park, Hyun Jin.

In: Process Biochemistry, Vol. 46, No. 3, 01.03.2011, p. 631-635.

Research output: Contribution to journalArticle

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