Abstract
This study investigated the effect of molecular architecture of amphiphilic star polymers on micelle formation and drug loading and releasing. For this, multi-armed star block copolymers having poly(ethylene glycol) as a hydrophilic block and poly(ε-caprolactone) as a hydrophobic block were synthesized by using a divergent synthetic method consisting of a coupling reaction and a ring opening polymerization. The molecular weight and molecular weight distribution of the block copolymers were characterized by 1 H NMR and GPC measurements. Dynamic light scattering and fluorescence spectroscopic analysis were employed to observe micellization, drug loading, and drug release behaviors. We have figured out that the number of arms is a critical factor that changes critical micelle concentration as well as drug loading and releasing behaviors; increase in the number of arms not only led to lowering the critical micelle concentration and drug release rate but also increased the micelle size and drug loading efficiency.
| Original language | English |
|---|---|
| Pages (from-to) | 1817-1827 |
| Number of pages | 11 |
| Journal | Colloid and Polymer Science |
| Volume | 291 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2013 Aug 1 |
| Externally published | Yes |
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Keywords
- Drug loading
- Drug releasing
- Molecular architecture
- Polymeric micelle
- Star polymers
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Polymers and Plastics
- Colloid and Surface Chemistry
- Materials Chemistry
Cite this
Effect of molecular architecture on micellization, drug loading and releasing of multi-armed poly(ethylene glycol)-b-poly(ε-caprolactone) star polymers. / Lim, Hyung Jun; Lee, Hyunsuk; Kim, Keon Hyeong; Huh, June; Ahn, Cheol Hee; Kim, Jin Woong.
In: Colloid and Polymer Science, Vol. 291, No. 8, 01.08.2013, p. 1817-1827.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of molecular architecture on micellization, drug loading and releasing of multi-armed poly(ethylene glycol)-b-poly(ε-caprolactone) star polymers
AU - Lim, Hyung Jun
AU - Lee, Hyunsuk
AU - Kim, Keon Hyeong
AU - Huh, June
AU - Ahn, Cheol Hee
AU - Kim, Jin Woong
PY - 2013/8/1
Y1 - 2013/8/1
N2 - This study investigated the effect of molecular architecture of amphiphilic star polymers on micelle formation and drug loading and releasing. For this, multi-armed star block copolymers having poly(ethylene glycol) as a hydrophilic block and poly(ε-caprolactone) as a hydrophobic block were synthesized by using a divergent synthetic method consisting of a coupling reaction and a ring opening polymerization. The molecular weight and molecular weight distribution of the block copolymers were characterized by 1 H NMR and GPC measurements. Dynamic light scattering and fluorescence spectroscopic analysis were employed to observe micellization, drug loading, and drug release behaviors. We have figured out that the number of arms is a critical factor that changes critical micelle concentration as well as drug loading and releasing behaviors; increase in the number of arms not only led to lowering the critical micelle concentration and drug release rate but also increased the micelle size and drug loading efficiency.
AB - This study investigated the effect of molecular architecture of amphiphilic star polymers on micelle formation and drug loading and releasing. For this, multi-armed star block copolymers having poly(ethylene glycol) as a hydrophilic block and poly(ε-caprolactone) as a hydrophobic block were synthesized by using a divergent synthetic method consisting of a coupling reaction and a ring opening polymerization. The molecular weight and molecular weight distribution of the block copolymers were characterized by 1 H NMR and GPC measurements. Dynamic light scattering and fluorescence spectroscopic analysis were employed to observe micellization, drug loading, and drug release behaviors. We have figured out that the number of arms is a critical factor that changes critical micelle concentration as well as drug loading and releasing behaviors; increase in the number of arms not only led to lowering the critical micelle concentration and drug release rate but also increased the micelle size and drug loading efficiency.
KW - Drug loading
KW - Drug releasing
KW - Molecular architecture
KW - Polymeric micelle
KW - Star polymers
UR - http://www.scopus.com/inward/record.url?scp=84881155988&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84881155988&partnerID=8YFLogxK
U2 - 10.1007/s00396-013-2916-y
DO - 10.1007/s00396-013-2916-y
M3 - Article
AN - SCOPUS:84881155988
VL - 291
SP - 1817
EP - 1827
JO - Colloid and Polymer Science
JF - Colloid and Polymer Science
SN - 0303-402X
IS - 8
ER -