Effect of myopia and age on optic disc margin anatomy within the parapapillary atrophy area

Young Hoon Hwang, Jong Jin Jung, Young Min Park, Yong Yeon Kim, Sungwook Woo, Joo Hwa Lee

Research output: Contribution to journalArticle

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Abstract

Purpose: To evaluate the effect of myopia and age on temporal optic disc margin anatomy within the parapapillary atrophy (PPA) area by use of spectral-domain optical coherence tomography (OCT). Methods: Fifty young myopic eyes with PPA (myopic PPA group), 50 aged non-myopic eyes with PPA (aged PPA group), and 50 young non-myopic eyes without PPA (control group) were enrolled. High-definition OCT scanning was used to obtain horizontal cross-sectional optic nerve head (ONH) images. By use of these OCT scans we investigated three temporal optic disc margin structures: the configuration of the border tissue of Elschnig; the cross-sectional ONH structure coinciding with the clinically detected optic disc margin; and the integrity of the retinal layers within the PPA area. Results: The distribution of the configuration of the border tissue of Elschnig and the cross-sectional ONH structure coinciding with the clinically detected optic disc margin of the myopic PPA group differed significantly from those of the control group (P < 0.01) whereas those of the aged PPA group did not (P > 0.05). Other than the photoreceptor layer, the retinal layers within the PPA area were more commonly impaired in the myopic PPA group than in the aged PPA group (P < 0.001). Conclusions: Myopia and aging led to different structural changes in temporal optic disc margin anatomy within the PPA area. This finding implies that different mechanisms may underlie myopic and age-related PPA development.

Original languageEnglish
Pages (from-to)463-470
Number of pages8
JournalJapanese Journal of Ophthalmology
Volume57
Issue number5
DOIs
Publication statusPublished - 2013 Sep 1

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Optic Disk
Myopia
Atrophy
Anatomy
Optical Coherence Tomography
Control Groups
Vertebrate Photoreceptor Cells

Keywords

  • Age
  • Glaucoma
  • Myopia
  • Optical coherence tomography
  • Parapapillary atrophy

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Effect of myopia and age on optic disc margin anatomy within the parapapillary atrophy area. / Hwang, Young Hoon; Jung, Jong Jin; Park, Young Min; Kim, Yong Yeon; Woo, Sungwook; Lee, Joo Hwa.

In: Japanese Journal of Ophthalmology, Vol. 57, No. 5, 01.09.2013, p. 463-470.

Research output: Contribution to journalArticle

Hwang, Young Hoon ; Jung, Jong Jin ; Park, Young Min ; Kim, Yong Yeon ; Woo, Sungwook ; Lee, Joo Hwa. / Effect of myopia and age on optic disc margin anatomy within the parapapillary atrophy area. In: Japanese Journal of Ophthalmology. 2013 ; Vol. 57, No. 5. pp. 463-470.
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