Effect of Nanometric Lactobacillus plantarum in Kimchi on Dextran Sulfate Sodium-Induced Colitis in Mice

Hyun Ah Lee, Yeon Ju Bong, Hyunung Kim, Ji Kang Jeong, Hee Young Kim, Kwang Won Lee, Kun Young Park

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Nanometric Lactobacillus plantarum (nLp) is a processed form of Lab. plantarum derived from kimchi and is 0.5-1.0 μm in size. This study was undertaken to determine the effect of nLp and kimchi plus nLp (K-nLp) on a dextran sulfate sodium (DSS)-induced mouse model of colitis. Animals fed nLp or K-nLp had longer colons, but lower colon weights per unit length than DSS controls. In addition, nLp- or K-nLp-fed animals showed lower levels of proinflammatory cytokines and inflammatory genes in serum and in colon tissues, lower populations of total bacteria, but higher populations of lactic acid bacteria in feces, and lower activities of fecal β-glucosidase and β-glucuronidase. Furthermore, these suppressive activities of nLp on colitis were equivalent to or higher than those of naive Lab. plantarum. Consequently, nLp was found to exhibit anticolitic effects, and the addition of nLp to kimchi was found to enhance the protective activity of kimchi against DSS-induced colitis. These results suggest that nLp might be an effective substitute for live probiotics and be useful as a functional ingredient with the anticolitic activity by the probiotic and food processing industries.

Original languageEnglish
Pages (from-to)1073-1080
Number of pages8
JournalJournal of Medicinal Food
Volume18
Issue number10
DOIs
Publication statusPublished - 2015 Oct 1

Fingerprint

Lactobacillus plantarum
Dextran Sulfate
Colitis
Colon
Probiotics
Food-Processing Industry
Glucosidases
Bacteria
Glucuronidase
Feces
Population
Lactic Acid
Cytokines
Weights and Measures

Keywords

  • anticolitis
  • Balb/c mouse
  • kimchi
  • nanometric Lactobacillus plantarum

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Effect of Nanometric Lactobacillus plantarum in Kimchi on Dextran Sulfate Sodium-Induced Colitis in Mice. / Lee, Hyun Ah; Bong, Yeon Ju; Kim, Hyunung; Jeong, Ji Kang; Kim, Hee Young; Lee, Kwang Won; Park, Kun Young.

In: Journal of Medicinal Food, Vol. 18, No. 10, 01.10.2015, p. 1073-1080.

Research output: Contribution to journalArticle

Lee, Hyun Ah ; Bong, Yeon Ju ; Kim, Hyunung ; Jeong, Ji Kang ; Kim, Hee Young ; Lee, Kwang Won ; Park, Kun Young. / Effect of Nanometric Lactobacillus plantarum in Kimchi on Dextran Sulfate Sodium-Induced Colitis in Mice. In: Journal of Medicinal Food. 2015 ; Vol. 18, No. 10. pp. 1073-1080.
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