Abstract
Naturally occurring phenolic compounds, such as chavicol analogues, have been shown to have potent antioxidant and anti-inflammatory activities. We have previously isolated two chavicol acetate analogues, acetoxychavicol acetate (ACA) and hydroxychavicol acetate (HCA) from the rhizomes of Alpinia galanga. Although the function of ACA has been studied in many systems, the function of HCA has yet to be systemically examined. In this study, we have comparably examined the functions of ACA and HCA on the cytokine production in Th cells. ACA exhibited potent antioxidant activity and increased cell apoptosis; therefore, cytokine production by Th cells was diminished. Although HCA had neither antioxidant activity nor pro-apoptotic function, it was shown to increase IL-2 production and attenuate IFNγ expression in Th cells. In addition, we demonstrated that HCA suppressed T-bet expression, which is responsible for IL-2 suppression and IFNγ induction in Th cells and inhibited T-bet-mediated Th1 cell differentiation. Therefore, we suggest that HCA may be beneficial as therapeutics for treating inflammatory immune disorders caused by extravagant activation of Th1-mediated immune responses.
| Original language | English |
|---|---|
| Pages (from-to) | 448-454 |
| Number of pages | 7 |
| Journal | International Immunopharmacology |
| Volume | 9 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2009 Apr 1 |
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Keywords
- Acetoxychavicol acetate
- Hydroxychavicol acetate
- IFNγ
- IL-2
- T helper cell
- T-bet
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Pharmacology
Cite this
Effect of naturally occurring hydroxychavicol acetate on the cytokine production in T helper cells. / Min, Hyun Jung; Nam, Joo Won; Yu, Eun Sun; Hong, Jeong-Ho; Seo, Eun Kyoung; Hwang, Eun Sook.
In: International Immunopharmacology, Vol. 9, No. 4, 01.04.2009, p. 448-454.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of naturally occurring hydroxychavicol acetate on the cytokine production in T helper cells
AU - Min, Hyun Jung
AU - Nam, Joo Won
AU - Yu, Eun Sun
AU - Hong, Jeong-Ho
AU - Seo, Eun Kyoung
AU - Hwang, Eun Sook
PY - 2009/4/1
Y1 - 2009/4/1
N2 - Naturally occurring phenolic compounds, such as chavicol analogues, have been shown to have potent antioxidant and anti-inflammatory activities. We have previously isolated two chavicol acetate analogues, acetoxychavicol acetate (ACA) and hydroxychavicol acetate (HCA) from the rhizomes of Alpinia galanga. Although the function of ACA has been studied in many systems, the function of HCA has yet to be systemically examined. In this study, we have comparably examined the functions of ACA and HCA on the cytokine production in Th cells. ACA exhibited potent antioxidant activity and increased cell apoptosis; therefore, cytokine production by Th cells was diminished. Although HCA had neither antioxidant activity nor pro-apoptotic function, it was shown to increase IL-2 production and attenuate IFNγ expression in Th cells. In addition, we demonstrated that HCA suppressed T-bet expression, which is responsible for IL-2 suppression and IFNγ induction in Th cells and inhibited T-bet-mediated Th1 cell differentiation. Therefore, we suggest that HCA may be beneficial as therapeutics for treating inflammatory immune disorders caused by extravagant activation of Th1-mediated immune responses.
AB - Naturally occurring phenolic compounds, such as chavicol analogues, have been shown to have potent antioxidant and anti-inflammatory activities. We have previously isolated two chavicol acetate analogues, acetoxychavicol acetate (ACA) and hydroxychavicol acetate (HCA) from the rhizomes of Alpinia galanga. Although the function of ACA has been studied in many systems, the function of HCA has yet to be systemically examined. In this study, we have comparably examined the functions of ACA and HCA on the cytokine production in Th cells. ACA exhibited potent antioxidant activity and increased cell apoptosis; therefore, cytokine production by Th cells was diminished. Although HCA had neither antioxidant activity nor pro-apoptotic function, it was shown to increase IL-2 production and attenuate IFNγ expression in Th cells. In addition, we demonstrated that HCA suppressed T-bet expression, which is responsible for IL-2 suppression and IFNγ induction in Th cells and inhibited T-bet-mediated Th1 cell differentiation. Therefore, we suggest that HCA may be beneficial as therapeutics for treating inflammatory immune disorders caused by extravagant activation of Th1-mediated immune responses.
KW - Acetoxychavicol acetate
KW - Hydroxychavicol acetate
KW - IFNγ
KW - IL-2
KW - T helper cell
KW - T-bet
UR - http://www.scopus.com/inward/record.url?scp=61649091283&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=61649091283&partnerID=8YFLogxK
U2 - 10.1016/j.intimp.2009.01.008
DO - 10.1016/j.intimp.2009.01.008
M3 - Article
C2 - 19208458
AN - SCOPUS:61649091283
VL - 9
SP - 448
EP - 454
JO - International Immunopharmacology
JF - International Immunopharmacology
SN - 1567-5769
IS - 4
ER -